PMV Pharmaceuticals, which focuses on the discovery and development of small molecule therapies targeting p53, reported the results from the Phase I, first-in-human portion of […]
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Precise protein expression through microRNA-mediated gene dosage compensation
Tools of the Trade Published: 27 February 2026 Nature Reviews Molecular Cell Biology (2026)Cite this article Subjects Transgene expression in cells and organisms underpins much […]
Publisher Correction: Mammalian synthetic gene circuits for biopharmaceutical development & manufacture
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium […]
TRIM13 in situ engineering boosts anti-inflammatory capacity of CAR-Ms for liver fibrosis therapy
Introduction Liver fibrosis is an aberrant wound-healing response to chronic liver injury, afflicting millions of people worldwide, which ultimately progresses to cirrhosis and leads to […]
Cullin 3 substrate-adaptor protein 1 (MtCSP1) modulates nodulation through interaction with the GTPase ARFA1
References Bailey-Serres, J., Sorenson, R. & Juntawong, P. Getting the message across: Cytoplasmic ribonucleoprotein complexes. Trends Plant Sci. 14, 443–453. https://doi.org/10.1016/j.tplants.2009.05.004 (2009). Google Scholar Ban, […]
Safety and biodistribution of intrathecal administration of mesenchymal stem cells (MSCs) and neurotrophin-releasing nanoparticles in a porcine CSF-guided delivery model for amyotrophic lateral sclerosis (ALS) drug discovery
References Sabatelli, M., Conte, A. & Zollino, M. Clinical and genetic heterogeneity of amyotrophic lateral sclerosis. Clin. Genet. 83, 408–416 (2013). Google Scholar Deda, H. […]
Unraveling Tempeh through omics: a scoping review of fermentation pathways and functional health benefits
References Romulo, A & Surya, R. Tempe: a traditional fermented food of Indonesia and its health benefits. Int. J. Gastron. Food Sci. 26, https://doi.org/10.1016/j.ijgfs.2021.100413 (2021). […]
Dysregulation of the DNA damage response by phosphorothioate antisense oligonucleotides
References Blackford, A. N. & Jackson, S. P. ATM, ATR, and DNA-PK: the trinity at the heart of the DNA damage response. Mol. Cell 66, […]
Pangenome-based design of strain-specific primers enables precise monitoring of bacteria in human microbiome intervention trials
References Larsen, I. S. et al. Experimental diets dictate the metabolic benefits of probiotics in obesity. Gut Microbes 15, (2023). Nicola, T. et al. A […]
Applications of Opuntia ficus-indica (L.) mill seed oil from eastern morocco including chemical profiling, antibacterial activity, and docking
References Nounah, I. et al. Effect of seed’s geographical origin on cactus oil physico-chemical characteristics, oxidative stability, and antioxidant activity. Food Chemistry: X 22, 101445 […]
