Mutactimycins H–J, antimycobacterial anthracyclines, from a thermophilic actinomycete of the genus Gandjariella

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Mutactimycins H–J, antimycobacterial anthracyclines, from a thermophilic actinomycete of the genus Gandjariella

References

  1. Barka EA, Vatsa P, Sanchez L, et al. Taxonomy, physiology, and natural products of Actinobacteria. Microbiol Mol Biol Rev. 2016;80:1–43.

    PubMed  Google Scholar 

  2. Saito S, Oku N, Igarashi Y. Mycetoindole, an N-acyl dehydrotryptophan with plant growth inhibitory activity from an actinomycete of the genus Actinomycetospora. J Antibiot. 2022;75:44–7.

    CAS  Google Scholar 

  3. Elsbaey M, Oku N, Abdel-Mottaleb MSA, Igarashi Y. Allostreptopyrroles A–E, β-alkylpyrrole derivatives from an actinomycete Allostreptomyces sp. RD068384. Beilstein J Org Chem. 2024;20:1981–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Liu C, Zhang Z, Fukaya K, Urabe D, Harunari E, Oku N, Igarashi Y. Catellatolactams A–C, plant growth-promoting ansamacrolactams from a rare actinomycete of the genus Catellatospora. J Nat Prod. 2022;85:1993–9.

    CAS  PubMed  Google Scholar 

  5. Nime MJ, Yamamura H, Hayakawa M, Matsuura N, Oku N, Igarashi Y. Cryptoic acids A and B, benzene-containing polyketides, and cyclocryptamide, a modified diketopiperazine, from an actinomycete of the genus Cryptosporangium. J Antibiot. 2025;78:141–8.

    CAS  Google Scholar 

  6. Lu S, Zhou T, Fukaya K, Harunari E, Oku N, Urabe D, Igarashi Y. Krasilnikolides A and B and detalosylkrasilnikolide A, cytotoxic 20-membered macrolides from the genus Krasilnikovia: assignment of anomeric configuration by J-based configuration analysis. J Nat Prod. 2022;85:2796–803.

    CAS  PubMed  Google Scholar 

  7. Saito S, Xiaohanyao Y, Zhou T, Nakajima-Shimada J, Tashiro E, Triningsih DW, Harunari E, Oku N, Igarashi Y. Phytohabitols A-C, δ-lactone-terminated polyketides from an actinomycete of the genus Phytohabitans. J Nat Prod. 2022;8:1697–703.

    Google Scholar 

  8. Parte AC, Sardà Carbasse J, Meier-Kolthoff JP, Reimer LC, Göker M. List of prokaryotic names with standing in nomenclature (LPSN) moves to the DSMZ. Int J Syst Evol Microbiol;. 2020;70:5607–12.

    PubMed  PubMed Central  Google Scholar 

  9. Dictionary of Natural Products 33.2 Chemical Search.https://dnp.chemnetbase.com/faces/chemical/ChemicalSearch.xhtml. Accessed 7 Apr 2025.

  10. Ningsih F, Yokota A, Sakai Y, Nanatani K, Yabe S, Oetari A, Sjamsuridzal W. Gandjariella thermophila gen. nov., sp. nov., a new member of the family Pseudonocardiaceae, isolated from forest soil in a geothermal area. Int J Syst Evol Microbiol. 2019;69:3080–6.

    CAS  PubMed  Google Scholar 

  11. Zhu Y, Kong Y, Hong Y, Zhang L, Li S, Hou S, Chen X, Xie T, Hu Y, Wang X. Huoshanmycins A‒C, new polyketide dimers produced by endophytic Streptomyces sp. HS-3-L-1 from Dendrobium huoshanense. Front Chem. 2022;9:807508.

    PubMed  PubMed Central  Google Scholar 

  12. Anouar EH, Osman CP, Weber JFF, Ismail NH. UV/visible spectra of a series of natural and synthesised anthraquinones: experimental and quantum chemical approaches. SpringerPlus. 2014;3:233.

    PubMed  PubMed Central  Google Scholar 

  13. Hopp DC, Rabenstein J, Rhea J, Smith C, Romari K, Clarke M, Francis L, Irigoyen M, Milanowski D, Luche M, Carr GJ, Mocek U. Mutactimycin E, a new anthracycline antibiotic with Gram-positive activity. J Antibiot. 2008;61:675–9.

    CAS  Google Scholar 

  14. Tanaka T, Nakashima T, Ueda T, Tomii K, Kouno I. Facile discrimination of aldose enantiomers by reversed-phase HPLC. Chem Pharm Bull. 2007;55:899–901.

    CAS  Google Scholar 

  15. Jin WZ, Cheng J, Zhang YB, Li HL, Tao PZ. Isolation and structure determination of mutactimycin A, a new anthracycline antibiotic. Kangshengsu. 1990;15:399–406.

    CAS  Google Scholar 

  16. Zhang Y, Jin W. Isolation and structure determination of minor components of mutactimycins, a group of new anthracycline antibiotics. Kangshengsu. 1991;16:157–64.

    CAS  Google Scholar 

  17. Astakala RV, Preet G, Milne BF, Tibyangye J, Razmilic V, Castro JF, Asenjo JA, Andrews B, Ebel R, Jaspars M. Mutactimycin AP, a new mutactimycin isolated from an actinobacteria from the Atacama Desert. Molecules. 2022;27:7185.

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Zitouni A, Mathieu F, Coppel Y, Pont F, Sabau N, Lebrihi A. Mutactimycin PR, a new anthracycline antibiotic from Saccharothrix sp. SA 103. J Antibiot. 2004;57:373–8.

    CAS  Google Scholar 

  19. Mikami Y, Yazawa K, Ohashi S, Maeda A, Akao M. SO 75R1, a new mutactimycin derivative produced by Nocardia brasiliensis. J Antibiot. 1992;45:995–7.

    CAS  Google Scholar 

  20. Speitling M, Nattewan P, Yazawa K, Mikami Y, Gruen Wollny I, Ritzau M, Laatsch H, Graefe U. Demethyl mutactimycins, new anthracycline antibiotics from Nocardia and Streptomyces strains. J Antibiot. 1998;51:693–8.

    CAS  Google Scholar 

  21. Bols M, Binderup L, Hansen J, Rasmussen P. Synthesis and collagenase inhibition of new glycosides of aranciamycinone: the aglycon of the naturally occurring antibiotic aranciamycin. Carbohydr Res. 1992;235:141–9.

    CAS  PubMed  Google Scholar 

  22. Luzhetskyy A, Mayer A, Hoffmann J, Pelzer S, Holzenkaemper M, Schmitt B, Wohlert S, Vente A, Bechthold A. Cloning and heterologous expression of the aranciamycin biosynthetic gene cluster revealed a new flexible glycosyltransferase. Chem Bio Chem. 2007;8:599–602.

    CAS  PubMed  Google Scholar 

  23. Khalil ZG, Raju R, Piggott AM, Salim AA, Blumenthal A, Capon RJ. Aranciamycins I and J, antimycobacterial anthracyclines from an Australian marine-derived Streptomyces sp. J Nat Prod. 2015;78:949–52.

    CAS  PubMed  Google Scholar 

  24. Koyama N, Kojima S, Nonaka K, Masuma R, Matsumoto M, Omura S, et al. Calpinactam, a new anti-mycobacterial agent, produced by Mortierella alpina FKI-4905. J Antibiot. 2010;63:183–16.

    CAS  Google Scholar 

  25. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; Approved standard—Ninth Edition, 9th ed, 32. Wayne, PA, USA: 2012.

  26. Reference method for broth dilution antifungal susceptibility testing of yeasts.; Approved standard—Third Edition, 3rd ed, vol. 28. Wayne, PA, USA: 2008.

  27. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983;65:55–63.

    CAS  PubMed  Google Scholar 

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