A search-and-branch mechanism for microtubule sensing

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A search-and-branch mechanism for microtubule sensing
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Biochemical sensing

Nature Chemical Engineering (2025)Cite this article

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An engineered confinement device reveals how the microtubule cytoskeleton senses and adapts to its environment by harnessing the interplay between catastrophe instability and branching nucleation.

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Fig. 1: Boundary sensing and self-organization of branching microtubule networks in confined microchannels.

References

  1. Gudimchuk, N. B. & McIntosh, J. R. Nat. Rev. Mol. Cell Biol. 22, 777–795 (2021).

    Article  PubMed  CAS  Google Scholar 

  2. Minc, N., Burgess, D. & Chang, F. Cell 144, 414–426 (2011).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  3. Mitchison, T. & Kirschner, M. Nature 312, 237–242 (1984).

    Article  PubMed  CAS  Google Scholar 

  4. Janson, M. E., de Dood, M. E. & Dogterom, M. J. Cell Biol. 161, 1029–1034 (2003).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  5. Zaferani, M., Song, R., Wingreen, N. S., Stone, H. A. & Petry, S. Nat. Chem. Eng. https://doi.org/10.1038/s44286-025-00264-0 (2025).

    Article  Google Scholar 

  6. Petry, S. et al. Cell 152, 768–777 (2013).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. Takagi, J. et al. Dev. Cell 49, 267–278 (2019).

    Article  PubMed  CAS  Google Scholar 

  8. Dogterom, M. & Koenderink, G. H. Nat. Rev. Mol. Cell Biol. 20, 38–54 (2019).

    Article  PubMed  CAS  Google Scholar 

  9. Bieling, P. et al. Cell 164, 115–127 (2016).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Physics, Academia Sinica, Taipei, Taiwan

    Ryota Sakamoto

  2. Department of Chemical Engineering, Kyoto University, Kyoto, Japan

    Yusuke T. Maeda

Authors

  1. Ryota Sakamoto
  2. Yusuke T. Maeda

Corresponding authors

Correspondence to Ryota Sakamoto or Yusuke T. Maeda.

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Competing interests

The authors declare no competing interests.

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Sakamoto, R., Maeda, Y.T. A search-and-branch mechanism for microtubule sensing. Nat Chem Eng (2025). https://doi.org/10.1038/s44286-025-00276-w

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  • DOI: https://doi.org/10.1038/s44286-025-00276-w