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An innovative method to trace tumour evolution using patterns of fluctuating DNA modifications could be implemented in the clinic to predict cancer progression.
By
- Pavlo Lutsik
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Pavlo Lutsik is in the Department of Oncology, Catholic University of Leuven (KU Leuven), Leuven 3000, Belgium.
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- Veselin Manojlovic
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Veselin Manojlovic is at the Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK.
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- George S. Vassiliou
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George S. Vassiliou is at the Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK.
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doi: https://doi.org/10.1038/d41586-025-02256-9
References
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Gabbutt, C. et al. Nature https://doi.org/10.1038/s41586-025-09374-4 (2025).
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Gerstung, M. et al. Nature 578, 122–128 (2020).
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Navin, N. et al. Nature 472, 90–94 (2011).
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Lomakin, A. et al. Nature 611, 594–602 (2022).
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Brocks, D. et al. Cell Rep. 8, 798–806 (2014).
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Meir, Z., Mukamel, Z., Chomsky, E., Lifshitz, A. & Tanay, A. Nature Genet. 52, 709–718 (2020).
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Gabbutt, C. et al. Nature Biotechnol. 40, 720–730 (2022).
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Scherer, M. et al. Nature 643, 478–487 (2025).
Competing Interests
The authors declare no competing interests.
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