Panelists:
Brianna Jayanthi, PhD
Principal Scientist
Asimov
Panelist
Brianna Jayanthi, PhD
Brianna Jayanthi, PhD, is a principal scientist at Asimov, where she has helped lead the development of next-generation cell lines for viral vector manufacturing. Since joining Asimov in 2019, she has helped launch both the company’s CHO-based biologics and HEK-based lentiviral vector production platforms, achieving major advances in titer and scalability. Jayanthi earned her PhD in systems, synthetic, and physical biology from Rice University, where she focused on engineering nanobody-based circuits for spatiotemporal control of protein function in mammalian cells. She has published and presented on topics spanning synthetic biology, viral vector engineering, and cell line development. Her current work centers on building high-yield, stable packaging and producer systems that enable scalable lentiviral vector production.
- Time:
Lentiviral vectors (LVVs) are widely used as a delivery system for ex vivo cell and gene therapies. In recent years, growing interest in using LVVs for in vivo therapies has driven new demand for high-quality LVVs at scale. Transient transfection systems, the dominant method used for LVV production, have well-documented limitations in scalability and product quality. In response to these limitations, therapeutic developers have begun adopting stable LV production systems, which promise to bring LVV manufacturing in line with the gold-standard practices used for protein biologics production.
In this GEN webinar, LV expert Brianna Jayanthi, PhD, will discuss how Asimov’s LV Edge Producer and Packaging Systems are leading to higher-quality, higher-productivity cell lines to support clinical and commercial LV therapies. She will present a case study evaluating transient, semi-stable, and stable LVV production systems through a manufacturing and product quality lens and offer guidance to help determine which production system is best suited for various therapeutic use cases.
A live Q&A session will follow the presentation, offering you a chance to pose questions to our expert panelist.
Produced with support from:
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