A bioabsorbable body-coupling-electrotherapy suture

a-bioabsorbable-body-coupling-electrotherapy-suture
A bioabsorbable body-coupling-electrotherapy suture

Nature Communications , Article number:  (2025) Cite this article

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Abstract

Sutures are pivotal medical devices for postoperative incision management. The inherent capacity of sutures to regulate wound healing and promote regeneration has the potential to significantly reduce patient discomfort and conserve medical resources. Here, we developed a bioabsorbable body-coupling electrotherapy suture that modulates healing from inflammation to remodeling, enabling healthy repair. The suture combines high tensile strength, flexibility, and degradability. The conversion of body-coupled electromagnetic energy through the suture enabled electrically synergistic therapeutic capabilities. By converting body-coupled electromagnetic energy, it provides synergistic therapy: dielectric polarization accelerates antimicrobial and anti-inflammatory effects, while dielectric voltage difference enhances healing factor expression. This fully physical approach reduces reliance on silver nanoparticles. In vitro and in vivo studies confirmed stable performance, achieving more than 1.43-fold improvement in healing efficiency compared with single-function sutures and reducing postoperative infections. Offering immobilization, stage-wide modulation, sustainability, and low energy demand, this technology represents a significant advancement in surgical practice.

Data availability

All data supporting the findings of this study are available within the article and its supplementary files. Any additional requests for information can be directed to, and will be fulfilled by, the corresponding authors. Source data are provided with this paper.

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Acknowledgements

We gratefully acknowledge the financial support by Scientific Research Innovation Capability Support Project for Young Faculty (ZYGXQNJSKYCXNLZCXM-M5), National Natural Science Foundation of China (No. 82301331, No. 82330034, and No. 82271161), Key Technologies Research and Development Program (2024YFC2418303), DHU Distinguished Young Professor Program (LZA2023001), and the Fundamental Research Funds for the Central Universities (CUSF-DH-D-2025005).

Author information

Author notes

  1. These authors contributed equally: Zhouquan Sun, Yuefan Jin, Hui Su

Authors and Affiliations

  1. State Key Laboratory of Advanced Fiber Materials, College of Materials Science and Engineering, Donghua University, Shanghai, PR China

    Zhouquan Sun, Hui Su, Yaogang Li, Qinghong Zhang, Kerui Li, Hongzhi Wang & Chengyi Hou

  2. Department of Otolaryngology-Head and Neck Surgery, Otolaryngology Institute of Shanghai JiaoTong University, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, PR China

    Yuefan Jin, Linpeng Li, Shan-kai Yin, Chengyi Hou & Hui Wang

Authors

  1. Zhouquan Sun
  2. Yuefan Jin
  3. Hui Su
  4. Yaogang Li
  5. Qinghong Zhang
  6. Kerui Li
  7. Hongzhi Wang
  8. Linpeng Li
  9. Shan-kai Yin
  10. Chengyi Hou
  11. Hui Wang

Contributions

C.Y.H., S.K.Y., H.W., and L.P.L. guided the project. Z.Q.S. conceived the idea and designed the experiment. Z.Q.S. fabricated the BET-suture. Z.Q.S., Y.F.J., and H.S. performed the experiments and measurements. S.K.Y., and H.W. guided the biomolecular mechanism. C.Y.H., Y.G.L., Q.H.Z., and K.R.L. revised the manuscript. All authors analyzed the experimental data, drew the figures and prepared the manuscript. All authors discussed the results and reviewed the manuscript.

Corresponding authors

Correspondence to Linpeng Li, Chengyi Hou or Hui Wang.

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Competing interests

The authors declare no competing interests.

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Nature Communications thanks Trilochan Bhatta, Emin Istif, and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. A peer review file is available.

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Sun, Z., Jin, Y., Su, H. et al. A bioabsorbable body-coupling-electrotherapy suture. Nat Commun (2025). https://doi.org/10.1038/s41467-025-66045-8

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  • DOI: https://doi.org/10.1038/s41467-025-66045-8