- Article
- Open access
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- Zhouquan Sun1 na1,
- Yuefan Jin2 na1,
- Hui Su1 na1,
- Yaogang Li1,
- Qinghong Zhang ORCID: orcid.org/0000-0002-4373-76651,
- Kerui Li ORCID: orcid.org/0000-0003-0933-89321,
- Hongzhi Wang ORCID: orcid.org/0000-0002-5469-23271,
- Linpeng Li ORCID: orcid.org/0000-0003-0540-23192,
- Shan-kai Yin ORCID: orcid.org/0000-0003-3689-85992,
- Chengyi Hou ORCID: orcid.org/0000-0003-4142-29821,2 &
- …
- Hui Wang ORCID: orcid.org/0009-0004-1615-655X2
Nature Communications , Article number: (2025) Cite this article
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Subjects
Abstract
Sutures are pivotal medical devices for postoperative incision management. The inherent capacity of sutures to regulate wound healing and promote regeneration has the potential to significantly reduce patient discomfort and conserve medical resources. Here, we developed a bioabsorbable body-coupling electrotherapy suture that modulates healing from inflammation to remodeling, enabling healthy repair. The suture combines high tensile strength, flexibility, and degradability. The conversion of body-coupled electromagnetic energy through the suture enabled electrically synergistic therapeutic capabilities. By converting body-coupled electromagnetic energy, it provides synergistic therapy: dielectric polarization accelerates antimicrobial and anti-inflammatory effects, while dielectric voltage difference enhances healing factor expression. This fully physical approach reduces reliance on silver nanoparticles. In vitro and in vivo studies confirmed stable performance, achieving more than 1.43-fold improvement in healing efficiency compared with single-function sutures and reducing postoperative infections. Offering immobilization, stage-wide modulation, sustainability, and low energy demand, this technology represents a significant advancement in surgical practice.
Data availability
All data supporting the findings of this study are available within the article and its supplementary files. Any additional requests for information can be directed to, and will be fulfilled by, the corresponding authors. Source data are provided with this paper.
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Acknowledgements
We gratefully acknowledge the financial support by Scientific Research Innovation Capability Support Project for Young Faculty (ZYGXQNJSKYCXNLZCXM-M5), National Natural Science Foundation of China (No. 82301331, No. 82330034, and No. 82271161), Key Technologies Research and Development Program (2024YFC2418303), DHU Distinguished Young Professor Program (LZA2023001), and the Fundamental Research Funds for the Central Universities (CUSF-DH-D-2025005).
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Sun, Z., Jin, Y., Su, H. et al. A bioabsorbable body-coupling-electrotherapy suture. Nat Commun (2025). https://doi.org/10.1038/s41467-025-66045-8
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DOI: https://doi.org/10.1038/s41467-025-66045-8
