Multiplexed lipid nanoparticle barcoding reveals tissue-dynamic kinetic insights and enriched cellular tropism in hepatic zones

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Authors and Affiliations

1. Department of Biomedical Engineering, Department of Biochemistry, Simmons Comprehensive Cancer Center, Program in Genetic Drug Engineering, The University of Texas Southwestern Medical Center, Dallas, TX, USA

   Stephen T. Moore, Xizhen Lian, Amogh Vaidya, Sumanta Chatterjee, Julien Santelli, Yehui Sun, Lukas Farbiak & Daniel J. Siegwart

2. Children’s Research Institute, Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, Children’s Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX, USA

   Stephen T. Moore & Hao Zhu

Contributions

Conceptualization: D.J.S., H.Z., and S.T.M.; Methodology: D.J.S., H.Z., S.T.M., and X.L.; Investigation; S.T.M, X.L., A.V., Y.S., S.C., and J.S.; Manuscript; D.J.S., H.Z., S.T.M., X.L., L.F., Y.S., and A.V.

Corresponding authors

Correspondence to Hao Zhu or Daniel J. Siegwart.

Competing interests

The authors acknowledge competing interests in ReCode Therapeutics (D.J.S.), Signify Bio (D.J.S. and L.F.), Newlimit (H.Z.), Chroma Therapeutics (H.Z.), Quotient Therapeutics (H.Z.), and Jumble Therapeutics (D.J.S. and H.Z.). The remaining authors declare no competing interests.

Peer review information

Nature Communications thanks Bowen Li and the other anonymous reviewer(s) for their contribution to the peer review of this work. [A peer review file is available].

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