Towards credible digital twins for basic and preclinical research

1. National Academies of Sciences, Engineering, and Medicine. Foundational Research Gaps and Future Directions for Digital Twins (National Academies Press, 2024).

2. Coveney, P., Highfield, R., Stahlberg, E. & Vázquez, M. Digital twins and big AI: the future of truly individualised healthcare. npj Digit. Med. 8, 494 (2025).

   Article  Google Scholar 

3. Sel, K. et al. Building digital twins for cardiovascular health: from principles to clinical impact. J. Am. Heart Assoc. 13, e031981 (2024).

   Article  Google Scholar 

4. Wolpert, D. M. & Miall, R. C. Forward models for physiological motor control. Neural Netw. 9, 1265–1279 (1996).

   Article  Google Scholar 

5. Bates, J. H. T. Lung Mechanics: An Inverse Modeling Approach (Cambridge Univ. Press, 2009).

6. Yadan, Z. et al. An expert review of the inverse problem in electrocardiographic imaging for the non-invasive identification of atrial fibrillation drivers. Comput. Methods Programs Biomed. 240, 107676 (2023).

   Article  Google Scholar 

7. Sel, K. et al. Survey and perspective on verification, validation, and uncertainty quantification of digital twins for precision medicine. npj Digit. Med. 8, 40 (2025).

   Article  Google Scholar 

8. Ates, H. C. et al. End-to-end design of wearable sensors. Nat. Rev. Mater. 7, 887–907 (2022).

   Article  ADS  MathSciNet  Google Scholar 

9. Akbarialiabad, H. et al. Bridging silicon and carbon worlds with digital twins and on-chip systems in drug discovery. npj Syst. Biol. Appl. 10, 150 (2024).

   Article  Google Scholar 

10. Tudor, B. H. et al. A scoping review of human digital twins in healthcare applications and usage patterns. npj Digit. Med. 8, 587 (2025).

    Article  Google Scholar 

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Authors and Affiliations

1. Center for Precision Medicine and Data Sciences, University of California, Davis, Davis, CA, USA

   Colleen E. Clancy

2. Department of Physiology and Membrane Biology, University of California, Davis, Davis, CA, USA

   Colleen E. Clancy

3. Department of Pharmacology, University of California, Davis, Davis, CA, USA

   Colleen E. Clancy

4. Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA

   Bennett A. Landman

Corresponding author

Correspondence to Colleen E. Clancy.

Competing interests

The authors declare no competing interests.