Simultaneous epigenomic profiling and regulatory activity measurement using e2MPRA

The code used for data processing and analysis in this study is available at: https://github.com/ziczhang/e2MPRA_analysis and at the Zenodo repository⁴⁸.

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Authors and Affiliations

1. Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan

   Zicong Zhang, Guillaume Bourque & Fumitaka Inoue

2. Institute for Personalized Medicine, Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA, USA

   Ilias Georgakopoulos-Soares

3. Department of Human Genetics, McGill University, Montréal, QC, Canada

   Guillaume Bourque

4. Victor Phillip Dahdaleh Institute of Genomic Medicine at McGill University, Montréal, QC, Canada

   Guillaume Bourque

5. Canadian Center for Computational Genomics, McGill University, Montréal, QC, Canada

   Guillaume Bourque

6. Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA

   Nadav Ahituv

7. Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA

   Nadav Ahituv

Contributions

F.I. and N.A. conceived the study. Z.Z., I.G. and F.I. designed the e2MPRA library. Z.Z. and F.I. performed experiments. Z.Z. analyzed data. Z.Z., F.I. and N.A. wrote the paper. I.G. and G.B. assisted with manuscript writing and editing.

Corresponding authors

Correspondence to Nadav Ahituv or Fumitaka Inoue.

Competing interests

F.I. receives funding from Relation Therapeutics. N.A. is a Cofounder and on the scientific advisory board of Regel Therapeutics Inc. N.A. received funding from BioMarin Pharmaceutical Inc. The remaining authors declare no competing interests.

Peer review information

Nature Communications thanks Nicolae Radu Zabet, and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. A peer review file is available.

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