Viscoelastic hydrogel primed CAR-macrophage for pulmonary fibrosis treatment

Posted on
viscoelastic-hydrogel-primed-car-macrophage-for-pulmonary-fibrosis-treatment
Viscoelastic hydrogel primed CAR-macrophage for pulmonary fibrosis treatment

References

  1. Hirayama, D., Iida, T. & Nakase, H. The phagocytic function of macrophage-enforcing innate immunity and tissue homeostasis. Int. J. Mol. Sci. 19, 92 (2017).

    Google Scholar 

  2. Chen, S. et al. Macrophages in immunoregulation and therapeutics. Sig. Transduct. Target Ther. 8, 1–35 (2023).

    Google Scholar 

  3. Klichinsky, M. et al. Human chimeric antigen receptor macrophages for cancer immunotherapy. Nat. Biotechnol. 38, 947–953 (2020).

    Google Scholar 

  4. Zhang, J. et al. Generation of anti-GD2 CAR macrophages from human pluripotent stem cells for cancer immunotherapies. Stem Cell Rep. 18, 585–596 (2023).

    Google Scholar 

  5. Lu, J. et al. CAR Macrophages: a promising novel immunotherapy for solid tumors and beyond. Biomark. Res. 12, 86 (2024).

    Google Scholar 

  6. Hadiloo, K., Taremi, S., Heidari, M. & Esmaeilzadeh, A. The CAR macrophage cells, a novel generation of chimeric antigen-based approach against solid tumors. Biomark. Res. 11, 103 (2023).

    Google Scholar 

  7. Dai, H. et al. Chimeric antigen receptor-modified macrophages ameliorate liver fibrosis in preclinical models. J. Hepatol. 80, 913–927 (2024)

  8. Kisseleva, T. & Brenner, D. A. Fibrogenesis of parenchymal organs. Proc. Am. Thorac. Soc. 5, 338–342 (2008).

    Google Scholar 

  9. Taskar, V. S. & Coultas, D. B. Is idiopathic pulmonary fibrosis an environmental disease?. Proc. Am. Thorac. Soc. 3, 293–298 (2006).

    Google Scholar 

  10. Richeldi, L., Collard, H. R. & Jones, M. G. Idiopathic pulmonary fibrosis. Lancet 389, 1941–1952 (2017).

    Google Scholar 

  11. Ley, B. & Collard, H. R. Epidemiology of idiopathic pulmonary fibrosis. Clin. Epidemiol. 5, 483–492 (2013).

    Google Scholar 

  12. Sgalla, G., Biffi, A. & Richeldi, L. Idiopathic pulmonary fibrosis: diagnosis, epidemiology and natural history. Respirology 21, 427–437 (2016).

    Google Scholar 

  13. Sauleda, J., Núñez, B., Sala, E. & Soriano, J. B. Idiopathic pulmonary fibrosis: epidemiology, natural history, phenotypes. Med Sci. 6, 110 (2018).

    Google Scholar 

  14. Martinez, F. J. et al. Idiopathic pulmonary fibrosis. Nat. Rev. Dis. Prim. 3, 1–19 (2017).

    Google Scholar 

  15. White, M. J. V. et al. Blocking antibodies against integrin-α3, -αM, and -αMβ2 de-differentiate myofibroblasts, and improve lung fibrosis and kidney fibrosis. Sci. Rep. 14, 21623 (2024).

    Google Scholar 

  16. Yang, A.-T. et al. Fibroblast activation protein activates macrophages and promotes parenchymal liver inflammation and fibrosis. Cell Mol. Gastroenterol. Hepatol. 15, 841–867 (2022).

    Google Scholar 

  17. Lavis, P., Garabet, A., Cardozo, A. K. & Bondue, B. The fibroblast activation protein alpha as a biomarker of pulmonary fibrosis. Front. Med. 11, 1393778 (2024).

  18. Lei, A. et al. A second-generation M1-polarized CAR macrophage with antitumor efficacy. Nat. Immunol. 25, 102–116 (2024).

    Google Scholar 

  19. Wang, X. et al. Metabolic reprogramming via ACOD1 depletion enhances function of human induced pluripotent stem cell-derived CAR-macrophages in solid tumors. Nat. Commun. 14, 5778 (2023).

    Google Scholar 

  20. Tang, C. et al. mRNA-laden lipid-nanoparticle-enabled in situ CAR-macrophage engineering for the eradication of multidrug-resistant bacteria in a sepsis mouse model. ACS Nano 18, 2261–2278 (2024).

    Google Scholar 

  21. Liu, M. et al. CAR-macrophages and CAR-T cells synergistically kill tumor cells in vitro. Cells 11, 3692 (2022).

    Google Scholar 

  22. Murray, P. J. Macrophage polarization. Annu. Rev. Physiol. 79, 541–566 (2017).

    Google Scholar 

  23. Das, A. et al. Monocyte and macrophage plasticity in tissue repair and regeneration. Am. J. Pathol. 185, 2596–2606 (2015).

    Google Scholar 

  24. Sridharan, R., Cavanagh, B., Cameron, A. R., Kelly, D. J. & O’Brien, F. J. Material stiffness influences the polarization state, function and migration mode of macrophages. Acta Biomater. 89, 47–59 (2019).

    Google Scholar 

  25. Chen, M. et al. Substrate stiffness modulates bone marrow-derived macrophage polarization through NF-κB signaling pathway. Bioact. Mater. 5, 880–890 (2020).

    Google Scholar 

  26. Trappmann, B. et al. Extracellular-matrix tethering regulates stem-cell fate. Nat. Mater. 11, 642–649 (2012).

    Google Scholar 

  27. Tetrick, M. G. & Murphy, C. J. Leveraging tunable nanoparticle surface functionalization to alter cellular migration. ACS Nanosci. Au 4, 205–215 (2024).

    Google Scholar 

  28. Jiang, S. et al. Cryoprotectant enables structural control of porous scaffolds for exploration of cellular mechano-responsiveness in 3D. Nat. Commun. 10, 3491 (2019).

    Google Scholar 

  29. Kalashnikov, N. & Moraes, C. Substrate viscoelasticity affects human macrophage morphology and phagocytosis. Soft Matter 19, 2438–2445 (2023).

    Google Scholar 

  30. Zhou, Y.-W. & Wu, Y. Substrate viscoelasticity amplifies distinctions between transient and persistent LPS-induced signals. Adv. Health Mater. 11, e2102271 (2022).

    Google Scholar 

  31. Hossain, M. Z. & Stroberg, W. Bilayer tension-induced clustering of the UPR sensor IRE1. Biochim. Biophys. Acta Biomembr. 1866, 184262 (2024).

    Google Scholar 

  32. Xie, P. et al. Membrane proteins and membrane curvature: mutual interactions and a perspective on disease treatments. Biomolecules 13, 1772 (2023).

    Google Scholar 

  33. Shi, Z. & Baumgart, T. Membrane tension and peripheral protein density mediate membrane shape transitions. Nat. Commun. 6, 5974 (2015).

    Google Scholar 

  34. Lachowski, D. et al. Substrate stiffness-driven membrane tension modulates vesicular trafficking via caveolin-1. ACS Nano 16, 4322–4337 (2022).

    Google Scholar 

  35. Fournier, J.-B. Membrane protein clustering from tension and multibody interactions. EPL 146, 57001 (2024).

    Google Scholar 

  36. Beedle, A. E., Williams, A., Relat-Goberna, J. & Garcia-Manyes, S. Mechanobiology — chemical origin of membrane mechanical resistance and force-dependent signaling. Curr. Opin. Chem. Biol. 29, 87–93 (2015).

    Google Scholar 

  37. Li, M., Xing, X., Yuan, J. & Zeng, Z. Research progress on the regulatory role of cell membrane surface tension in cell behavior. Heliyon 10, e29923 (2024).

    Google Scholar 

  38. Wang, L.-C. S. et al. Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity. Cancer Immunol. Res. 2, 154–166 (2014).

    Google Scholar 

  39. Tran, E. et al. Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia. J. Exp. Med 210, 1125–1135 (2013).

    Google Scholar 

  40. Brocks, B. et al. Species-crossreactive scFv against the tumor stroma marker “fibroblast activation protein” selected by phage display from an immunized FAP−/− knock-out mouse. Mol. Med. 7, 461–469 (2001).

    Google Scholar 

  41. Leyva, F. J., Anzinger, J. J., McCoy, J. P. & Kruth, H. S. Evaluation of transduction efficiency in macrophage colony-stimulating factor differentiated human macrophages using HIV-1 based lentiviral vectors. BMC Biotechnol. 11, 13 (2011).

    Google Scholar 

  42. Burke, B., Sumner, S., Maitland, N. & Lewis, C. E. Macrophages in gene therapy: cellular delivery vehicles and in vivo targets. J. Leukoc. Biol. 72, 417–428 (2002).

    Google Scholar 

  43. Distler, T. et al. Ionically and enzymatically dual cross-linked oxidized alginate gelatin hydrogels with tunable stiffness and degradation behavior for tissue engineering. ACS Biomater. Sci. Eng. 6, 3899–3914 (2020).

    Google Scholar 

  44. Abasalizadeh, F. et al. Alginate-based hydrogels as drug delivery vehicles in cancer treatment and their applications in wound dressing and 3D bioprinting. J. Biol. Eng. 14, 8 (2020).

    Google Scholar 

  45. Sprenger, L. et al. Composite alginate dialdehyde-gelatin (ADA-GEL) hydrogel containing short ribbon-shaped fillers for skeletal muscle tissue biofabrication. ACS Appl. Mater. Interfaces 16, 44605–44622 (2024).

    Google Scholar 

  46. Page-McCaw, A., Ewald, A. J. & Werb, Z. Matrix metalloproteinases and the regulation of tissue remodelling. Nat. Rev. Mol. Cell Biol. 8, 221–233 (2007).

    Google Scholar 

  47. Ozga, A. J., Chow, M. T. & Luster, A. D. Chemokines and the immune response to cancer. Immunity 54, 859 (2021).

    Google Scholar 

  48. Hu, J. et al. Cell membrane patches transfer CAR molecules from a cellular depot to conventional T cells for constructing innovative fused-CAR-T cells without necessitating genetic modification. Exp. Hematol. Oncol. 13, 75 (2024).

    Google Scholar 

  49. Kouro, T., Himuro, H. & Sasada, T. Exhaustion of CAR T cells: potential causes and solutions. J. Transl. Med. 20, 239 (2022).

    Google Scholar 

  50. Ni, Y. et al. Macrophages modulate stiffness-related foreign body responses through plasma membrane deformation. Proc. Natl. Acad. Sci. 120, e2213837120 (2023).

    Google Scholar 

  51. Pandzic, E., Whan, R. & Macmillan, A. Rapid FLIM measurement of membrane tension probe flipper-TR. In Membrane Lipids: Methods and Protocols (ed. Cranfield, C. G.) 257–283 (Springer US, New York, NY, 2022). https://doi.org/10.1007/978-1-0716-1843-1_20.

  52. Ruan, H. et al. N-(3-oxododecanoyl) homoserine lactone is a generalizable plasma membrane lipid-ordered domain modifier. Front. Physiol. 12, 758458 (2022).

    Google Scholar 

  53. Zhang, W. et al. Chimeric antigen receptor macrophage therapy for breast tumours mediated by targeting the tumour extracellular matrix. Br. J. Cancer 121, 837–845 (2019).

    Google Scholar 

  54. Gialeli, C. et al. PDGF/PDGFR signaling and targeting in cancer growth and progression: focus on tumor microenvironment and cancer-associated fibroblasts. Curr. Pharm. Des. 20, 2843–2848 (2014).

    Google Scholar 

  55. Díaz-Lezama, N. et al. PDGF receptor alpha signaling is key for müller cell homeostasis functions. Int. J. Mol. Sci. 22, 1174 (2021).

    Google Scholar 

  56. Klinkhammer, B. M., Floege, J. & Boor, P. PDGF in organ fibrosis. Mol. Asp. Med. 62, 44–62 (2018).

    Google Scholar 

  57. Xiao, W. et al. Chimeric antigen receptor-modified T-cell therapy for platelet-derived growth factor receptor α-positive rhabdomyosarcoma. Cancer 126, 2093–2100 (2020).

    Google Scholar 

  58. Cho, J. H. et al. Engineering advanced logic and distributed computing in human CAR immune cells. Nat. Commun. 12, 792 (2021).

    Google Scholar 

  59. Zah, E. et al. Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma. Nat. Commun. 11, 2283 (2020).

    Google Scholar 

  60. Yang, C., Tibbitt, M. W., Basta, L. & Anseth, K. S. Mechanical memory and dosing influence stem cell fate. Nat. Mater. 13, 645–652 (2014).

    Google Scholar 

  61. Dudaryeva, O. Y., Bernhard, S., Tibbitt, M. W. & Labouesse, C. Implications of cellular mechanical memory in bioengineering. ACS Biomater. Sci. Eng. 9, 5985–5998 (2023).

    Google Scholar 

  62. Na, J. et al. Mechanical memory based on chromatin and metabolism remodeling promotes proliferation and smooth muscle differentiation in mesenchymal stem cells. FASEB J. 38, e23538 (2024).

    Google Scholar 

  63. Scott, A. K. et al. Mechanical memory stored through epigenetic remodeling reduces cell therapeutic potential. Biophys. J. 122, 1428–1444 (2023).

    Google Scholar 

  64. Kreysing, E. et al. Effective cell membrane tension is independent of polyacrylamide substrate stiffness. PNAS Nexus 2, pgac299 (2023).

    Google Scholar 

  65. Sitarska, E. & Diz-Muñoz, A. Pay attention to membrane tension: mechanobiology of the cell surface. Curr. Opin. Cell Biol. 66, 11–18 (2020).

    Google Scholar 

Download references