Panelists:
Ray Zhang, PhD
Associate Director, QC-Analytics
Franklin Biolabs
Panelist
Ray Zhang, PhD
Ray Zhang, PhD, is a seasoned biochemist and industry leader with over five years of experience directing analytical development and QC operations for biologics. Currently serving as the associate director of QC-Analytics at Franklin Biolabs, he oversees the validation of complex analytical methods and ensures regulatory compliance for late-stage clinical products.
Zhang is a recognized technical expert in mass photometry and LC-MS/MS, with a proven track record of managing the analytical method lifecycle from development through technical transfer to external partners. His professional background includes a key leadership role at the University of Pennsylvania’s Gene Therapy Program, where he directed physical and chemical characterization to accelerate method readiness for AAV-based therapeutics.
He holds a PhD in molecular biosciences and bioengineering from the University of Hawaii at Manoa and has previously contributed his analytical expertise to organizations such as WuXi Biologics and Rockland Immunochemicals.
- Time:
In today’s competitive biologics and gene therapy landscape, CDMO quality control teams are under pressure to deliver faster tech transfer, reduce costs, and maintain consistently high product quality. As molecules become more complex, with AAV partial capsids, aggregates, and heterogeneous populations increasingly common, traditional analytical technologies often create bottlenecks that impact timelines and productivity.
Mass photometry (MP) is a rapid, label‑free, single‑particle mass measurement technique that provides native‑state insight into product quality in minutes using minimal sample. It can complement established orthogonal methods like AUC, delivering actionable data earlier, more frequently, and with lower operational burden.
In this GEN webinar Ray Zhang, PhD, associate director, QC-Analytics at Franklin Biolabs will introduce the principles of mass photometry and highlight where it adds value across the analytical lifecycle. He will cover operational considerations, including method robustness, system suitability, and the transition to 21 CFR Part 11 compliant workflows. He will also share a case study that demonstrates how rapid MP screening streamlines real-world CDMO QC workflows and improves overall productivity. Key takeaways from the webinar include:
- How MP compares to AUC in terms of speed, sample efficiency, and intuitive data interpretation
- QC-relevant applications of MP including lot-to-lot comparability, stability, and stress studies, and in-process or release testing
A live Q&A session will follow the presentation, offering you a chance to pose questions to our expert panelist.
Produced with support from:
The post Accelerating GMP Quality Control with Mass Photometry from Development to Release appeared first on GEN – Genetic Engineering and Biotechnology News.
