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Authors and Affiliations

1. Clinical R&D, OCT Therapies and Research Pvt Ltd Mumbai, Maharashtra, 400078, India

   Caroline Mathen, Wilfrid Dsouza, Aishwarya Nithyanand & Rutika Ghosalkar

2. Sanctuary for Research and Development (sa-Ford) Raigad, Maharashtra, 410208, India

   Deepali Sharma & Mangi Lal Choudhary

3. Kode Lab, Tumor Immunology & Immunotherapy Group, Advanced Center for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, 410210, India

   Trupti Ninad Pradhan, Apeksha Kesarwani & Jyoti Kode

4. Facility for Immunomodulatory Activity Testing (FIAT), Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, 410210, India

   Divya Gujar & Jyoti Kode

5. Laboratory Animal Facility, Animal Oncology Group, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, , Kharghar, Navi Mumbai, 410210, India

   Arvind Ingle

6. Comparative Oncology Program & Translational Preclinical Imaging & Radiotherapy Facility, Animal Oncology Group,, Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, 410210, India

   Pradip Chaudhari

7. Department of Radiation Oncology, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, 410210, India

   Jayant Sastri Goda

8. Homi Bhabha National Institute (HBNI) , Anushakti Nagar, Mumbai, 400094, India

   Arvind Ingle, Pradip Chaudhari, Jayant Sastri Goda & Jyoti Kode

9. OCT Biopharma Inc, NB E1E 2B5, Moncton , Canada

   Caroline Mathen

Contributions

Caroline Mathen: Conceptualization, Study design, Methodology, Investigation, Supervision, Data curation, Validation, Writing – original draft, review & editingWilfrid Dsouza: Formal analysis, Methodology, Investigation, Supervision, Data curation, Validation, Writing –original draft, review & editingDeepali Sharma: Supervision, Investigation, Formal analysis, Data curation, review & editingTrupti Ninad Pradhan: Investigation, Data curation, review & final approvalApeksha Kesarwani: Methodology, Investigation, Data curation, review & final approvalDivya Gujar: Methodology, Investigation, Data curation, review & final approvalMangi Lal Choudhary: Investigation, Data curation, review & final approvalAishwarya Nithyanand: Investigation, Data curation, review & final approvalRutika Ghosalkar: Investigation, Data curation, review & final approvalArvind Ingle: Animal house support, review & final approvalPradip Chaudhari: Small animal radiation and imaging, review & final approvalJayant Sastri Goda: Small animal radiation, Methodology, Investigation, review & final approvalJyoti Kode: Conceptualization, Study design, Methodology, Investigation, Supervision, Data curation, Writing – original draft, review & editing.

Corresponding authors

Correspondence to Caroline Mathen or Jyoti Kode.

Competing interests

Caroline Mathen is the Director of OCT Therapies and Research Pvt Ltd.The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Ethics statements

1. The study approved by Institutional Animal Ethics Committee (IAEC) of the test facility under the project title “Repeated Dose 28 Day Oral Toxicity Study in Rat” on July 06, 2023 (JDM/IAEC/2022/03/115). 2. The study was approved by Institutional Animal Ethics Committee (IAEC) of the test facility under the project title “Repeated Dose 28 Day Oral Toxicity Study in Mice” on July 06, 2023 (JDM/IAEC/2023/02/087 and JDM/IAEC/2023/02/088). 3. The study was approved by the Institutional Animals Ethics Committee [(IAEC Proposal No.SF_23_55_001) (23_657)] under the project title “Evaluation of efficacy of an indigenously prepared topical formulation containing Mesenchymal Stromal Cell Conditioned Media for prevention/mitigation of chemotherapy induced oral mucositis”. 4. The study was approved by the Institutional Animals Ethics Committee (IAEC) project # 46/2022 under the project title “Evaluation of efficacy of an indigenously prepared topical formulation containing mesenchymal stem cell conditioned media for prevention/ mitigation of radiotherapy induced toxicity”. 5. Authors confirm that the study was conducted and reported in accordance with ARRIVE guidelines.

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This work is protected under PCT/IN2018/050078.

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