References
-
Kashyap, A., Sarma, A., Das, B. K. & Goswami, A. K. Rational design of natural products for drug discovery. computational methods ration. Drug Design 285–309 (2025).
-
Javed, A., Hashmi, M. S., Javaid, U. & Amjad, R. Classification and therapeutic applications of plant secondary metabolites. Pharmacognosy and Phytochemistry: Principles, Techniques, and Clinical Applications 189–206 (2025).
-
Martín-Bravo, S. et al. Molecular systematics and biogeography of Resedaceae based on ITS and trnL-F sequences. Mol. Phylogenet. Evol. 44, 1105–1120 (2007).
-
Punt, W. & Marks, A. R. Rev. Palaeobot. Palynol. 88, 47–59 (1995).
-
Mitsiogianni, M. et al. The role of isothiocyanates as cancer chemo-preventive, chemo-therapeutic and anti-melanoma agents. Antioxidants 8, 106 (2019).
-
Ullah, O. et al. Bilal S.Aroma profile and biological effects of Ochradenus arabicus essential oils: A comparative study of stem, flowers, and leaves. Molecules 27, 5197 (2022).
-
Ali, M. A. et al. Status of Reseda pentagyna Abdallah & AG Miller (Resedaceae) inferred from combined nuclear ribosomal and chloroplast sequence data. Bangladesh J. Plant. Taxonomy. 20, 233–238 (2013).
-
Cilden, E. & Yildirimli, Ş. Taxonomic revision of the genus Reseda L.(Resedaceae) in Turkey. (2020).
-
Al-Qurainy, F. et al. Estimation of genome size in the endemic species Reseda pentagyna and the locally rare species Reseda lutea using comparative analyses of flow cytometry and k-mer approaches. Plants 10, 1362 (2021).
-
Kiziltaş, H. Comprehensive evaluation of Reseda lutea L.(Wild Mignonette) and 7 isolated flavonol glycosides: determination of antioxidant activity, anti-Alzheimer, antidiabetic and cytotoxic effects with in vitro and in silico methods. Turk. J. Chem. 46, 1185–1198 (2022).
-
Al-Mazroa, S., Al-Wahaibi, L., Mousa, A. & Al-Khathlan, H. Essential oil of some seasonal flowering plants grown in Saudi Arabia. Arab. J. Chem. 8, 212–217 (2015).
-
Ullah, R. & Alqahtani, A. S. GC-MS analysis, heavy metals, biological, and toxicological evaluation of Reseda muricata and Marrubium vulgare methanol extracts. Evidence-Based Complementary and Alternative Medicine 2284328 (2022).
-
Chroho, M., Rouphael, Y., Petropoulos, S. A. & Bouissane, L. Carvacrol and thymol content affects the antioxidant and antibacterial activity of Origanum compactum and Thymus zygis essential oils. Antibiotics 13, 139 (2024).
-
Islam, M. T. et al. El-Nashar HA.Anti-inflammatory effects of thymol: an emphasis on the molecular interactions through in vivo approach and molecular dynamic simulations. Front. Chem. 12, 1376783 (2024).
-
Mączka, W., Twardawska, M. & Grabarczyk, M. Wińska K.Carvacrol—A natural phenolic compound with antimicrobial properties. Antibiotics 12, 824 (2023).
-
Potra Cicalău, G. I. et al. Ganea M.Assessing the antioxidant benefits of topical carvacrol and magnolol periodontal hydrogel therapy in periodontitis associated with diabetes in wistar rats. Dentistry J. 11, 284 (2023).
-
Fan, K. et al. Carvacrol inhibits proliferation and induces apoptosis in human colon cancer cells. Anti-cancer drugs. 26, 813–823 (2015).
-
Sampaio, L. A., Pina, L. T. S., Serafini, M. R. & Tavares, D. S. Guimaraes AG.Antitumor effects of carvacrol and thymol: a systematic review. Front. Pharmacol. 12, 702487 (2021).
-
Wang, W., Kannan, P., Xue, J. & Kannan, K. Synthetic phenolic antioxidants, including butylated hydroxytoluene (BHT), in resin-based dental sealants. Environ. Res. 151, 339–343 (2016).
-
Porto, C. et al. Morel AF.(R)-(-)-carvone and (1R, 4R)-trans-(+)-dihydrocarvone from poiretia latifolia vogel. J. Braz. Chem. Soc. 21, 782–786 (2010).
-
Abbas, M. et al. Antimicrobial properties and therapeutic potential of bioactive compounds in nigella sativa: a Review. Molecules 29, 4914 (2024).
-
Aly, E., Khajah, M. A. & Masocha, W. β-Caryophyllene, a CB2-receptor-selective phytocannabinoid, suppresses mechanical allodynia in a mouse model of antiretroviral-induced neuropathic pain. Molecules 25, 106 (2019).
-
Nicolescu, A. et al. Rocchetti G.Optimized ultrasound-assisted enzymatic extraction of phenolic compounds from Rosa canina L. pseudo-fruits (rosehip) and their biological activity. Antioxidants 11, 1123 (2022).
-
de Oliveira, A. M. F. et al. Assis TS.Total phenolic content and antioxidant activity of some Malvaceae family species. Antioxidants 1, 33–43 (2012).
-
Morshedloo, M. R., Salami, S. A., Nazeri, V., Maggi, F. & Craker, L. Essential oil profile of oregano (Origanum vulgare L.) populations grown under similar soil and climate conditions. Ind. Crops Prod. 119, 183–190 (2018).
-
Alma, M. H., Mavi, A., Yildirim, A., Digrak, M. & Hirata, T. Screening chemical composition and in vitro antioxidant and antimicrobial activities of the essential oils from Origanum syriacum L. growing in Turkey. Biol. Pharm. Bull. 26, 1725–1729 (2003).
-
Khan, S. A., Al Kiyumi, A. R., Al Sheidi, M. S., Al Khusaibi, T. S. & Al Shehhi, N. M. Alam T.In vitro inhibitory effects on α-glucosidase and α-amylase level and antioxidant potential of seeds of Phoenix dactylifera L. Asian Pac. J. Trop. Biomed. 6, 322–329 (2016).
-
Ahmed, M. U., Ibrahim, A. & Dahiru, N. J. Mohammed HuS.Alpha amylase inhibitory potential and mode of inhibition of oils from Allium sativum (Garlic) and Allium cepa (Onion). Clin. Med. Insights: Endocrinol. Diabetes. 13, 1179551420963106 (2020).
-
Dalli, M. et al. In vitro α-amylase and hemoglobin glycation inhibitory potential of Nigella sativa essential oil, and molecular docking studies of its principal components. Front. Pharmacol. 13, 1036129 (2022).
-
Salazar, M. O., Osella, M. I., Arcusin, D. E., Lescano, L. E. & Furlan, R. L. New α-glucosidase inhibitors from a chemically engineered essential oil of Origanum vulgare L. Ind. Crops Prod. 156, 112855 (2020).
-
MahnashiMH et al. Phytochemical Analysis, α-Glucosidase and Amylase Inhibitory, and Molecular Docking Studies on Persicaria hydropiper L. Leaves Essential Oils. Evidence-Based Complement. Altern. Med. 7924171 (2022).
-
Tummers, B. & Green, D. R. Caspase-8: regulating life and death. Immunol. Rev. 277, 76–89 (2017).
-
Saddam, M. et al. Emerging biomarkers and potential therapeutics of the BCL-2 protein family: the apoptotic and anti-apoptotic context. Egypt. J. Med. Hum. Genet. 25, 12 (2024).
-
Khojali, W. M. et al. Alshammari RAR.Chemical composition, antibacterial activity and in vitro anticancer evaluation of Ochradenus baccatus methanolic extract. Medicina 59, 546 (2023).
-
Ali, M. A. et al. Assessment of biological activity and UPLC–MS based chromatographic profiling of ethanolic extract of Ochradenus arabicus. Saudi J. Biol. Sci. 23, 229–236 (2016).
-
Al-kawmani, A. A. et al. Apoptosis-inducing potential of biosynthesized silver nanoparticles in breast cancer cells. J. King Saud University-Science. 32, 2480–2488 (2020).
-
Russo, A., Graziano, A., Bruno, M., Cardile, V. & Rigano, D. Apoptosis induction of essential oils from Artemisia arborescens L. in human prostate cancer cells. J. Ethnopharmacol. 303, 115929 (2023).
-
Radulović, N. S., Zlatković, D. B., Ilić-Tomić, T., Senerović, L. & Nikodinovic-Runic, J. Cytotoxic effect of Reseda lutea L.: A case of forgotten remedy. J. Ethnopharmacol. 153, 125–132 (2014).
-
De, D., Chowdhury, P. & Panda, S. K. Ghosh U.Leaf extract and active fractions of Dillenia pentagyna Roxb. reduce in vitro human cancer cell migration via NF-κB pathway. Integr. Cancer Ther. 21, 15347354221128832 (2022).
-
Sitarek, P., Synowiec, E., Kowalczyk, T. & Śliwiński, T. & Skała E.An in vitro estimation of the cytotoxicity and genotoxicity of root extract from Leonurus sibiricus L. overexpressing AtPAP1 against different cancer cell lines. Molecules. 23, (2049). (2018).
-
Wolfe, K. L. & Liu, R. H. Apple peels as a value-added food ingredient. J. Agric. Food Chem. 51, 1676–1683 (2003).
-
Ordonez, A., Gomez, J. & Vattuone, M. Antioxidant activities of Sechium edule (Jacq.) Swartz extracts. Food Chem. 97, 452–458 (2006).
-
Tian, M. et al. Phytochemical analysis, antioxidant, antibacterial, cytotoxic, and enzyme inhibitory activities of Hedychium flavum rhizome. Front. Pharmacol. 11, 572659 (2020).
-
Reviana, R. et al. Analysis of antioxidant activity on cocktail honey products as female pre-conception supplements. Gac. Sanit. 35, S202–S205 (2021).
-
Yu, X., Zhao, M., Liu, F., Zeng, S. & Hu, J. Antioxidants in volatile Maillard reaction products: Identification and interaction. LWT-Food Sci. Technol. 53, 22–28 (2013).
-
Salem, N. et al. Variation in chemical composition of Eucalyptus globulus essential oil under phenological stages and evidence synergism with antimicrobial standards. Ind. Crops Prod. 124, 115–125 (2018).
-
Singh, P. et al. Extracellular synthesis of silver and gold nanoparticles by Sporosarcina koreensis DC4 and their biological applications. Enzym. Microb. Technol. 86, 75–83 (2016).
-
Basri, D. F. & Sandra, V. Synergistic interaction of methanol extract from Canarium odontophyllum Miq. Leaf in combination with oxacillin against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 33591. Int. J. Microbiol. (2016).
-
Aljeldah, M. M., Yassin, M. T., Mostafa, A. A. F. & Aboul-Soud, M. A. Synergistic antibacterial potential of greenly synthesized silver nanoparticles with fosfomycin against some nosocomial bacterial pathogens. Infection Drug Resistance 125–142 (2022).
-
Wickramaratne, M. N., Punchihewa, J. & Wickramaratne, D. In-vitro alpha amylase inhibitory activity of the leaf extracts of Adenanthera pavonina. BMC Complement. Altern. Med. 16, 1–5 (2016).
-
Kim, Y-M., Wang, M-H. & Rhee H-I.A novel α-glucosidase inhibitor from pine bark. Carbohydr. Res. 339, 715–717 (2004).
-
Mosmann, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 65, 55–63 (1983).
-
Alkhudhayri, A. A., Wahab, R., Siddiqui, M. A. & Ahmad, J. Selenium nanoparticles induce cytotoxicity and apoptosis in human breast cancer (MCF-7) and liver (HEPG2) cell lines. Nanosci. Nanatechnol. Lett. 12, 324–330 (2020).
-
Ghasemi, M., Turnbull, T., Sebastian, S. & Kempson, I. The MTT assay: utility, limitations, pitfalls, and interpretation in bulk and single-cell analysis. Int. J. Mol. Sci. 22, 12827 (2021).
-
Al-Dhabi, N. A. & Valan Arasu, M. Quantification of phytochemicals from commercial Spirulina products and their antioxidant activities. Evidence-Based Complementary and Alternative Medicine (2016).
-
Aziz, I. M. et al. Chemical composition, antioxidant, anticancer, and antibacterial activities of roots and seeds of Ammi visnaga L. Methanol Extract. Pharmaceuticals 17, 121 (2024).
-
Pagnotta, E. et al. Glucosinolates in Reseda lutea L.: Distribution in plant tissues during flowering time. Biochem. Syst. Ecol. 90, 104043. (2020). https://doi.org/10.1016/j.bse.2020.104043
-
Rather, M. A., Dar, B. A., Sofi, S. N., Bhat, B. A. & Qurishi, M. A. Foeniculum vulgare: A comprehensive review of its traditional use, phytochemistry, pharmacology, and safety. Arab. J. Chem. 9, 1574–1583. (2012). https://doi.org/10.1016/j.arabjc.2012.04.011
-
Dugo, G. et al. Characterization of cold-pressed and processed bergamot oils by using GC-FID, enantio-GC, MDGC, HPLC and HPLC-MS-IT-TOF. J. Essential Oil Res. 24(2):93–117. (2012). https://doi.org/10.1080/10412905.2012.659526
-
Zidorn, C. et al. Polyacetylenes from the Apiaceae vegetables carrot, celery, fennel, parsley, and parsnip and their cytotoxic activities. J. Agric. Food Chem. 53 (7), 2518–2523. (2005). https://doi.org/10.1021/jf048041s
-
Salatino, A., Salatino, M. L. F. & Negri, G. Traditional uses, chemistry and pharmacology of Croton species (Euphorbiaceae). J. Braz. Chem. Soc. 18 (1), 11–33. (2007). https://doi.org/10.1590/s0103-50532007000100002
