Spatial map of microglial diversity beyond proteopathy

spatial-map-of-microglial-diversity-beyond-proteopathy
Spatial map of microglial diversity beyond proteopathy
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Nature Immunology (2025)Cite this article

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Single-cell spatial proteomics paired with chromatin accessibility mapping identifies a diverse range of human microglial immune states. In Alzheimer’s disease, hippocampal microglia tend to lose antigen-presenting function and become disengaged from inhibitory synapses. Our dual-modality approach illustrates the importance of integrating local tissue architecture and cell identity to fully understand disease-associated immune remodeling.

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Fig. 1: Immune activation continuum of hippocampal microglia is perturbed in Alzheimer’s disease.

References

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This is a summary of: Mrdjen, D. et al. Spatial proteomics reveals Alzheimer’s disease-specific human microglial states. Nat. Immunol. https://doi.org/10.1038/s41590-025-02203-w (2025).

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Spatial map of microglial diversity beyond proteopathy. Nat Immunol (2025). https://doi.org/10.1038/s41590-025-02205-8

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  • DOI: https://doi.org/10.1038/s41590-025-02205-8