A functional map of m6A sites in cancer

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A functional map of m6A sites in cancer
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Cancer epigenetics

Nature Cancer (2026)Cite this article

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RNA N6-methyladenosine (m6A) is the most abundant internal RNA modification, yet its functional landscape in cancer remains poorly defined. A study now introduces a METTL3-based RNA base-editing screen that maps functional m6A sites and reveals m6A-dependent translational activation of the tumor suppressor CHD9 in prostate cancer and beyond.

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Fig. 1: Functional interrogation of m6A sites reveals a tumor-suppressive CHD9 pathway.

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Authors and Affiliations

  1. Department of Epigenetics & Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Yalong Wang & Han Xu

Corresponding author

Correspondence to Han Xu.

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Competing interests

The authors declare no competing interests.

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Wang, Y., Xu, H. A functional map of m6A sites in cancer. Nat Cancer (2026). https://doi.org/10.1038/s43018-026-01137-y

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