A prototype of a dialysate fluid-free wearable artificial kidney for dialysis on the go

a-prototype-of-a-dialysate-fluid-free-wearable-artificial-kidney-for-dialysis-on-the-go
A prototype of a dialysate fluid-free wearable artificial kidney for dialysis on the go
  • Research Briefing
  • Published:

Nature Chemical Engineering (2026)Cite this article

Subjects

The wearability of conventional artificial kidneys is limited by their dependence on large volumes of dialysate required for dialysis to remove excess water and toxins from the blood. Now, a dialysate-free wearable artificial kidney prototype employs vapor-driven water removal and adsorption to clear toxins. This system achieves a high water clearance rate in renal replacement therapy in animal models.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 12 digital issues and online access to articles

$119.00 per year

only $9.92 per issue

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: A dialysate-free WAK based on the liquid–gas phase transition.

References

  1. Ramada, D. L. et al. Portable, wearable and implantable artificial kidney systems: needs, opportunities and challenges. Nat. Rev. Nephrol. 19, 481–490 (2023). This review article highlights kidney failure as a major global health challenge affecting millions of individuals worldwide and discusses various aspects of different artificial kidney systems.

    Article  PubMed  PubMed Central  Google Scholar 

  2. McFarlane, P. A. et al. The quality of life and cost utility of home nocturnal and conventional in-center hemodialysis. Kidney Int. 64, 1004–1011 (2003). This article investigates the quality of life and cost effectiveness of hemodialysis devices.

    Article  PubMed  Google Scholar 

  3. Davenport, A. et al. A wearable haemodialysis device for patients with end-stage renal failure: a pilot study. Lancet 370, 2005–2010 (2007). This article presents a wearable hemodialysis device based on the principle of dialysate regeneration.

    Article  PubMed  Google Scholar 

  4. Savage, N. Could implantable artificial kidneys end the need for dialysis? Nature 615, S12–S13 (2023). This article highlights that the development of a portable dialysis device independent of an external water supply system can substantially enhance patient autonomy.

    Article  CAS  PubMed  Google Scholar 

  5. Deng, X. et al. Candle soot as a template for a transparent robust superamphiphobic coating. Science 335, 66–70 (2012). This article presents a method for fabricating super-liquid-repellent coatings.

    Article  Google Scholar 

Download references

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Luo, J. et al. A dialysate-free wearable artificial kidney prototype driven by a liquid–gas phase transition. Nat. Chem. Eng. https://doi.org/10.1038/s44286-026-00355-6 (2026).

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

A prototype of a dialysate fluid-free wearable artificial kidney for dialysis on the go. Nat Chem Eng (2026). https://doi.org/10.1038/s44286-026-00354-7

Download citation

  • Published:

  • Version of record:

  • DOI: https://doi.org/10.1038/s44286-026-00354-7