Illustration of the new analysis method. The tractors represent so-called transcription factors: proteins that bind to genetic switches to activate or deactivate genes. The method […]
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Scientists reengineer enzyme to study diseases via sugar patterns on the surface of cells
An illustration of the pig enzyme ST3Gal1 (green) bound to its sugar ligand (yellow sticks). Binding interfaces contain green (carbon), red (oxygen), and blue (nitrogen) […]
Protein Language Model Hits Undruggable Targets, No Structure Required
Pranam Chatterjee, PhD, assistant professor of bioengineering at the University of Pennsylvania (UPenn), emphasizes that text is all you need for artificial intelligence (AI) models […]
Rapidly Evolving Human Genomic Region Tied to Neural Development, Flexible Thinking
Human-accelerated regions (HARs) are sections of the human genome that have accumulated an unusually high level of mutations as humans split away from chimpanzees. Given […]
Tapping the microalgal potential: genetic precision and stress-induction for enhanced astaxanthin and biofuel production
Review Open access Published: 14 August 2025 Ankush Yadav1, Suhani Sharma1, Nitesh1, Rinku Meena1, Rupesh Bhardwaj1, Prashant Swapnil1 & … Mukesh Meena2 Biotechnology for Biofuels […]
Near-infrared long lifetime upconversion nanoparticles for ultrasensitive microRNA detection via time-gated luminescence resonance energy transfer
Introduction Lanthanide-doped upconversion nanoparticles (UCNPs), which can emit visible or shorter-wavelength near-infrared (NIR) luminescence under NIR excitation, offer considerable advantages, such as high photostability, non-photobleaching, […]
Chromosomal abnormalities of mesenchymal stromal cells in hematological malignancies
Introduction Genetic abnormalities in Hematological Malignancies (HMs) are key diagnostic markers in their respective Hematological Cells (HCs), serving as crucial indicators for identifying and classifying […]
Cryopreserved leukapheresis enables scalable and distributed CAR-T manufacturing: a multi-platform comparative study
Introduction Fresh leukapheresis exhibits time-sensitive viability decay (24-72-hour transport window)1,2,3. Current CAR-T production faces a paradoxical dilemma: While up to 33% of lymphoma patients are […]
A self-amplifying mRNA vaccine expressing PRV gD induces robust immunity against virulent mutants
Introduction Pseudorabies virus (PRV) belongs to the alphaherpesvirus subfamily within the Herpesviridae family and the Herpesvirales order. It can infect various livestock and wild animals, […]
Effect of tea manufacturing processes and cultivars on tea infusion color
Introduction Tea is among the most favored and economically accessible beverages globally, second only to water1. Prepared from the tender leaves of the Camellia sinensis […]