Introduction Transfer RNAs (tRNAs) are the fundamental adaptors of translation, linking mRNA decoding and polypeptide synthesis1. Biogenesis of tRNAs is complex: following transcription, precursor tRNA […]
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Accelerating the manufacturing of HIV Env protein vaccines for early phase clinical evaluation
Comment Open access Published: 20 August 2025 Michael N. Pensiero1 npj Vaccines volume 10, Article number: 199 (2025) Cite this article Subjects This commentary discusses the benefits in […]
Phytohormonal elicitation triggers oxidative stress and enhances menthol biosynthesis through modulation of key pathway genes in Mentha piperita L.
Introduction Medicinal plants have long been integral to global healthcare systems due to their capacity to synthesize a diverse array of specific organic compounds known […]
Feeding bees with engineered yeast combats colony decline
RESEARCH BRIEFINGS 20 August 2025 Nutritionally complete food for honeybees (Apis mellifera) has been generated by engineering yeast to produce rare but essential sterol molecules […]
Non-genetic neuromodulation with graphene optoelectronic actuators for disease models, stem cell maturation, and biohybrid robotics
Introduction The ability to modulate neural activity at will is essential for fundamental research and therapeutic applications, including understanding brain function, disease modeling, neuroengineering, and […]
Recent advances in enzyme engineering for improved deconstruction of poly(ethylene terephthalate) (PET) plastics
Introduction Many of the same properties that make plastics attractive in use–e.g., durability, non-reactivity, chemical, light, and thermal resistance–allow them to persist and accumulate in […]
An unnatural base pair for the detection of epigenetic cytosine modifications in DNA
Main Naturally occurring cytosine modifications, 5-methylcytosine (5mC) and its oxidized derivatives 5-hydroxymethyl-, 5-formyl- and 5-carboxylcytosine (5hmC, 5fC and 5caC, respectively), constitute part of the epigenetic […]
Computational and experimental discovery of peptide inhibitors targeting survivin for therapeutic potential in cancer
Introduction The functional characteristics of Survivin make it a distinctive protein with diverse roles, including the regulation of cell proliferation and apoptosis. Its expression pattern […]
Nfe2l1 dysfunction alters Parkinson’s disease-related gene expression and impairs neuronal differentiation under ubiquitin stress in neuronal differentiated P19 Cells
Introduction Neurogenesis is a highly intricate process, vital for the formation of a fully functional nervous system. Any disruptions in this process can lead to […]
Engineered yeast provides rare but essential pollen sterols for honeybees
Main Managed honeybees (Apis mellifera) are fundamental to modern agricultural systems and global food security because of the crucial pollination services they provide to crops. Honeybees […]