In this talk in GEN’s “The State of CRISPR & Genome Editing” virtual summit, originally broadcast on June 11, 2025, Alexis Komor, PhD, Associate Professor at University of California San Diego and Nicole Gaudelli, PhD, Entrepreneur-in-Residence at Google Ventures to discuss base editing.
Together they developed the first iterations of base editing while post docs with David Liu, PhD, at the Broad Institute. The significance of base editing was evident from the very first Nature paper in 2016, which Komor was the first author, providing the basis for engineering specific base substitutions in the genome—what Virginijus Siksnys, PhD, called “DNA surgery” in 2012.
The importance of this technology has been vividly demonstrated just in the past few months with the dramatic story of the de-extinction of the popular Game of Thrones creature—which was discussed in the closing interview of the summit—and the remarkable story of KJ an infant at Children’s Hospital of Philadelphia (CHOP) with an ultra-rare genetic disorder who was treated with a bespoke base editor.
The entire virtual summit is available to watch free on demand: bit.ly/CRISPR25
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