Bringing magnetofluorescent proteins into the cell

Subjects

Steel and colleagues report the development and application of magnetoresponsive fluorescent proteins in novel imaging contexts, including MRI of MFP-expressing cells.

Like many tools in modern biology, fluorescent proteins have developed from broad cross-disciplinary effort. In a Nature article, Harrison Steel (University of Oxford), Gabriel Abrahams (University of Oxford) and colleagues push an emerging branch of fluorescent protein development — magnetosensitive fluorescent proteins, in particular, MagLOV, developed by coauthors Maria Ingaramo and Andrew York (Calico Life Sciences) — into some intriguing new areas, demonstrating the use of MagLOV for often-disconnected fields like quantum property inference using a standard fluorescence microscope and a novel fluorescence-based magnetic resonance imaging (MRI) approach.

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