Schematic of the T7-ORACLE system. The genome is maintained by the non-mutagenic host replisome (gray), while an orthogonal T7 replisome (red) maintains only a dedicated […]
Category: Biotechnology Molecular & Computational biology
Molecular imaging tech measures forces in living cells with nanometer-level precision
Decoy DNA enhances super-resolution and extends the duration of live-cell molecular tension imaging. Credit: Angewandte Chemie International Edition (2025). DOI: 10.1002/anie.202506590 Together, these two breakthroughs […]
From fragments to function: Computer-based design for custom proteins
Helical shape of a protein. Credit: IBC – TU Graz In the ERC project HelixMold, a team from TU Graz developed a method for the […]
Scientists develop technology that brings new precision to genome editing
Credit: Pixabay/CC0 Public Domain The FDA’s approval of the first CRISPR-Cas9–based gene therapy marked a major milestone in biomedicine, validating genome editing as a promising […]
New malaria vaccine targets parasite’s fertilization complex to block transmission
Credit: Walter and Eliza Hall Institute of Medical Research WEHI researchers have visualized a key protein complex in malaria parasites for the first time, uncovering […]
Artificial protein engineering advances through molecular level forecasting
The Protein Domain Insertion Optimizer, abbreviated as ProDomino, can forecast which protein domains—like domino tiles—have to be fitted together to engineer a merged protein with […]
Study reveals simple peptides can mimic nature’s protein protection strategy
Electron microscopy image showing a mixture of porous spheres and half-dome particles formed by evaporation of a peptide solution. Credit: Sheng Zhang. Ph.D. A new […]
Innovative super-resolution imaging method for gentle live-cell imaging developed
Tracks the fate of one of these cloud-like foci through time in seconds; fast reappearance of Green signal after photobleaching indicates fast exchange of the […]
New AI tool illuminates ‘dark side’ of the human genome
Cells express a novel ShortStop-predicted microprotein (green), with cell nuclei stained blue. The pattern suggests microproteins are localized either in endosomes, which are organelles responsible […]
Shape complementarity enables precise protein binder design
New design pipeline yields high-affinity binders for diverse protein targets. Credit: MPI f. Biology Tübingen Recent advances in computational protein design have depended mainly on […]