Main Transthyretin amyloidosis (ATTR) is a systemic protein misfolding disorder caused by the deposition of amyloid fibrils derived from transthyretin (TTR), a tetrameric protein primarily […]
Category: CRISPR
CRISPR live-cell imaging reveals chromatin dynamics and enhancer interactions at multiple non-repetitive loci
Data availability The data supporting this study are provided in the article and in its Supplementary Information and Source Data files. Multi-omics data from published […]
CRISPR/dCas9-TET1–mediated epigenetic editing reactivates miR-200c in breast cancer cells
Introduction Cancer is basically a disease of dysregulation, characterized by the breakdown of cellular mechanisms that normally preserve identity, proliferation control, and tissue homeostasis1,2. This […]