RESEARCH HIGHLIGHT 30 January 2026 In patients with T cell acute lymphoblastic leukemia, base-edited CAR T cells — capable of destroying leukemic T cells while […]
Category: editing
In vivo base editing rescues ADPKD in a humanized mouse model
References Agborbesong, E., Li, L. X., Li, L. & Li, X. Molecular mechanisms of epigenetic regulation, inflammation, and cell death in ADPKD. Front. Mol. Biosci. […]
Editing DNA methylation in vivo
Data availability The RNA-seq, ChIP-seq, and whole genome bisulfilte genome sequencing data generated as part of this study have been deposited in the Gene Expression […]
In vivo gene editing of human hematopoietic stem and progenitor cells using envelope-engineered virus-like particles
Main Hematopoietic stem and progenitor cells (HSPCs) can sustain lifelong production of a diverse range of blood cell types through a hierarchically organized continuum of […]
Double-strand break-free and transgene-free genome editing in the microalga Nannochloropsis oceanica using removable vectors containing the CRISPR base editing system
Introduction Algal biodiesels have been proposed as potential candidates for sustainable new sources of energy. Because the production process involves the assimilation of carbon dioxide […]
ProPE expands the prime editing window and enhances gene editing efficiency where prime editing is inefficient
Main Prime editing (PE), which requires neither the generation of DNA double-strand breaks nor the use of donor DNA1, reduces the production of unwanted modifications […]
Gene editing and CRISPR-dependent homology-mediated end joining
Introduction All researchers who have for a long time been engaged in science are able to recall technological discoveries that substantially improved their day-to-day laboratory […]
Emerging trends in prime editing for precision genome editing
Introduction The study of pathogenic mutations found in patients and the development of gene therapies to address these genetic alterations have garnered substantial attention in […]