Introduction Organoids are the three-dimensional (3D) aggregations of cells formed by a controlled self-organization program, representing tissue and organ structures in vitro1,2. The kidney, which […]
Category: Engineering
Engineering the biophysical properties of lipid nanostructures for drug delivery
Peer, D. et al. Nanocarriers as an emerging platform for cancer therapy. Nat. Nanotechnol. 2, 751–760 (2007). Article CAS PubMed Google Scholar Patra, J. K. […]
Engineering the MmeFz2-ωRNA system for efficient genome editing through an integrated computational-experimental framework
Data availability Next-generation sequencing data are available at the National Center for Biotechnology Information (NCBI) Sequence Read Archive database under the BioProject accession code PRJNA1259048. Source […]
Engineering energy-efficient Saccharomyces cerevisiae for methanol and CO2 assimilation
References Boehm, S. et al. State of Climate Action 2023. World Resour. Inst https://www.wri.org/research/state-climate-action-2023 (2023). Sollai, S., Porcu, A., Tola, V., Ferrara, F. & Pettinau, […]
Engineering bispecific exosome activators of T cells to target immune checkpoint inhibitor-resistant metastatic melanoma
Data availability Sequences for all plasmids and primers are provided in Supplementary Information. The RNA-seq data for Fig. 3a were reanalyzed from the dataset deposited […]
Engineering bidirectional chloroplast promoters for tunable co-expression of multiple genes in microalgae (Chlamydomonas reinhardtii)
References Kumar, G. et al. Bioengineering of microalgae: recent advances, perspectives, and regulatory challenges for industrial application. Front. Bioeng. Biotechnol. 8, 914 (2020). Google Scholar […]
Engineering IL-21 secretion in T cells using druggable ligand-responsive stabilized domains
References Propper, D. J. & Balkwill, F. R. Harnessing cytokines and chemokines for cancer therapy. Nat. Reviews Clin. Oncol. 19, 237–253 (2022). Google Scholar Koh, […]
Engineering artificial biosynthetic pathway enables simultaneous production and in-situ bio-dyeing of indigoids for textiles
References Qin, Z., Wang, X., Gao, S., Li, D. & Zhou, J. Production of natural pigments using microorganisms. J. Agric. Food Chem. 71, 9243–9254 (2023). […]
Engineering filamentous potato virus X as a platform nanotechnology for nucleic acid gene delivery
Introduction The convergence of mRNA therapeutics with nanotechnology represents a transformative leap in next-generation therapeutics and offers profound implications for the treatment of diverse diseases. […]
Engineering microbial consortia for mixed plastic upcycling
References Filho, W. L. et al. An assessment of attitudes towards plastics and bioplastics in Europe. Sci. Total Environ. 755, 142732 (2021). Google Scholar Tiso, […]