References Ueda, N. et al. Immunotherapy perspectives in the new era of B-cell editing. Blood Adv. 5, 1770–1779 (2021). CAS Google Scholar Edelstein, J., Fritz, […]
Category: Engineering
In vivo engineering broadens CAR-T cell therapy use
RESEARCH HIGHLIGHT 05 August 2025 Chimeric antigen receptor (CAR)-T cell therapies have transformed the treatment of B cell malignancies, offering durable responses. However, their broader […]
Engineering of photo-inducible binary interaction tools for biomedical applications
Introduction Optogenetics and synthetic biology have greatly enhanced our ability to interrogate biological processes with unprecedented spatiotemporal resolution1,2,3,4. By acting as light-induced dimerization modules or […]
Engineering glycosyltransferases into glycan binding proteins using a mammalian surface display platform
Introduction Glycosylation is a ubiquitous molecular modification that regulates diverse biological processes including molecular recognition, cell adhesion, and signaling1,2. Glycan structure changes also serve as […]
Engineering of novel DNA polymerase variants for single enzyme quantitative multiplex reverse transcription-PCR
Introduction The combination of PCR with reverse transcription (RT) laid the basis for various powerful methods in the research field of molecular biotechnology and clinical […]