References Aw, S. S., Tang, M. X., Teo, Y. N. & Cohen, S. M. A conformation-induced fluorescence method for microRNA detection. Nucleic Acids Res. 44, […]
Category: programmable
Programmable translation
Research Highlight Published: 22 December 2025 RNA biotechnology Yiyun Song1 Nature Chemical Biology (2025)Cite this article Subjects Start codon selection by ribosomes is a crucial […]
Programmable Argonaute-mediated single-nucleotide variant sequencing of cell-free DNA for multi-cancer early detection
References Wan, J. C. M. et al. Liquid biopsies come of age: towards implementation of circulating tumour DNA. Nat. Rev. Cancer 17, 223–238 (2017). Google […]
Programmable targeted RNA degradation via dCas13d-directed chaperone-mediated autophagy (dCasCMA)
Introduction RNA plays a crucial role in various biological and pathological processes. Given that over 70% of the human genome is transcribed into RNA, with […]
Programmable promoter editing for precise control of transgene expression
Domingo, J. et al. Nonlinear transcriptional responses to gradual modulation of transcription factor dosage. Preprint at bioRxiv https://doi.org/10.1101/2024.03.01.582837, peer reviewed by eLife eeb.embo.org/doi/10.1101/2024.03.01.582837 (2025). Wang, […]
Programmable DNA shell scaffolds for directional membrane budding
Introduction Membrane budding is a ubiquitous biological phenomenon in which parent lipid membranes release daughter vesicles for the transport of materials across the membrane. In […]
Programmable antisense oligomers for phage functional genomics
Main The growing interest in bacteriophages is driven by the richness of unexplored genes that emerge in the phage–host conflict1,2. Targeted mapping and characterization of […]
Programmable protein ligation on cell surfaces
Main Cell-surface heterogeneity is exploited in nature as a central strategy for discrimination in multicellular systems with the purpose of modulating biological functions in time […]
A live, programmable microbiota therapeutic disables virulence in gut pathogens
Research Briefing Published: 21 July 2025 Nature Biomedical Engineering (2025)Cite this article Subjects Treatment of severe gastrointestinal illness caused by Shiga-toxin-producing enteropathogenic bacteria is a […]