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Category: Rational

Rational redesign of high-activity G-quadruplex DNAzyme through flanking and looping of nucleobases
  • Rational

Rational redesign of high-activity G-quadruplex DNAzyme through flanking and looping of nucleobases

  • January 12, 2026
  • 0

References Liu, R., Li, J., Salena, B. J. & Li, Y. Aptamer and DNAzyme based colorimetric biosensors for pathogen detection. Angew. Chem. Int. Ed. 64 (4), e202418725. […]

Rational design and in silico characterization of a multiepitope mRNA vaccine candidate against human metapneumovirus (hMPV) using reverse vaccinology and immunoinformatics approaches
  • Rational

Rational design and in silico characterization of a multiepitope mRNA vaccine candidate against human metapneumovirus (hMPV) using reverse vaccinology and immunoinformatics approaches

  • December 24, 2025
  • 0

References Panda, S., Mohakud, N. K., Pena, L. & Kumar, S. Human metapneumovirus: review of an important respiratory pathogen. Int. J. Infect. Dis. 25, 45–52 […]

Rational engineering of allosteric protein switches by in silico prediction of domain insertion sites
  • Rational

Rational engineering of allosteric protein switches by in silico prediction of domain insertion sites

  • August 4, 2025
  • 0

Main Domains are structural and functional subunits of proteins1. The rearrangement of existing domains into new combinations is a major source of evolutionary innovation2. While […]

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