Main Contractile injection systems (CISs) encompass a broad class of syringe-like protein complexes that enable prokaryotes and their viruses to inject effector molecules into nearby […]
Category: Targeted
Targeted gene editing and near-universal cDNA insertion of CYBA and CYBB as a treatment for chronic granulomatous disease
Introduction Chronic granulomatous disease (CGD) is an inborn error of immunity (IEI) with a prevalence of approximately 1:200,0001. It is caused by defects in the […]
Targeted delivery of the PKMYT1 inhibitor RP-6306 mediates PANoptosis in pancreatic cancer via mitotic catastrophe
Introduction Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent type of pancreatic cancer and is highly malignant. In recent years, immunotherapy and targeted therapy have […]
Targeted in vivo gene integration of a secretion-enabled GLP-1 receptor agonist reverses diet-induced non-genetic obesity and pre-diabetes
Introduction In vivo genome editing using tools like CRISPR-Cas9 have demonstrated great potential for correcting disease-causing mutations and ensuring sustained correction outcome in monogenic inherited […]