Levesque, S. & Bauer, D. E. CRISPR-based therapeutic genome editing for inherited blood disorders. Nat. Rev. Drug Discov. https://doi.org/10.1038/s41573-025-01236-y (2025). Article PubMed Google Scholar Raguram, […]
Category: Targeted
Targeted amplification of alternating electric fields using ferroelectric nanoparticles
Introduction Recent advances in pharmacology have integrated electronic devices due to factors such as portability, software development, precise modulation of physical stimuli, high accessibility, and […]
CD45-targeted pan-leukocyte imaging: mapping whole-body inflammatory activity with specificity and translational promise
In a study published recently in Nature, Salehi Farid and colleagues introduced CD45-PET, a pan-leukocyte imaging strategy targeting CD45, a highly abundant antigen, on nucleated […]
Targeted knock-in of human immune-regulatory genes into the porcine GGTA1 exon 4 reveals divergent expression on red blood cell membranes
Introduction In clinical settings, blood is constantly required in the treatment of patients with various conditions; however, the decline in blood donations, particularly during the […]
Targeted sequencing and iterative assembly of near-complete genomes
Introduction The capacity to obtain high quality and even complete telomere-to-telomere (T2T) assemblies for large eukaryotic genomes is transforming our understanding of genome architecture, variation […]
A targeted vector for brain endothelial cell gene delivery and cerebrovascular malformation modelling
Main The brain, despite being only 2% of body mass, consumes 20% of the glucose and 25% of the oxygen taken in by humans1. All […]
Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes
Main In the expanding field of genome editing, targeting chemical modifications to a specific DNA sequence offers an effective way to create precise genomic edits […]
Targeted and safe delivery of colchicine via polymeric nanocarriers for potential atherosclerosis therapy with in vitro and in vivo evaluation
Introduction Colchicine is an alkaloid derived from the tubers of the autumn crocus (Colchicum autumnale) and is one of the oldest known medicinal substances extracted […]
Targeted delivery of diverse biomolecules with engineered bacterial nanosyringes
Main Contractile injection systems (CISs) encompass a broad class of syringe-like protein complexes that enable prokaryotes and their viruses to inject effector molecules into nearby […]
Targeted gene editing and near-universal cDNA insertion of CYBA and CYBB as a treatment for chronic granulomatous disease
Introduction Chronic granulomatous disease (CGD) is an inborn error of immunity (IEI) with a prevalence of approximately 1:200,0001. It is caused by defects in the […]