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Authors and Affiliations

1. Peptide Biomedicine Laboratory (PBL), College of Biology, Hunan University, Changsha, Hunan, China

   Kefurong Deng, Dongzhe Zou, Zenan Zeng, Beiling Guo, Wensheng Gong, Yini Xu, Yachao Li & Xianghui Xu

2. State Key Laboratory of Chemo and Biosensing, Hunan Research Center of the Basic Discipline for Cell Signaling, Hunan Provincial Key Laboratory of Medical Virology, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha, Hunan, China

   Kefurong Deng, Yachao Li & Xianghui Xu

Contributions

X.X. and K.D. conceived and designed the study. K.D., D.Z., and Y. L. synthesized the chiral peptidoglycan mimics. K.D., D.Z., and Z.Z. investigated bacterial recognition and the incorporation mechanisms of peptidoglycan mimics into bacterial biosynthesis. K.D., W.G., and D.Z. conducted molecular dynamics simulations. K.D., D.Z., Z.Z., B.G., and Y.X. contributed to the in vivo animal studies. X.X. and K.D. wrote and revised the manuscript. K.D., D.Z., Z.Z., B.G., Y. L., and X.X. provided critical feedback on the manuscript. X.X. supervised the project.

Corresponding author

Correspondence to Xianghui Xu.

Competing interests

The authors declare no competing interests.

Peer review information

Nature Communications thanks Dicky Pranantyo, Wei Chen, and the other anonymous reviewer for their contribution to the peer review of this work. A peer review file is available.

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