CKAAKN peptide-conjugated long-circulating nanoliposomes for the targeted delivery of oridonin to pancreatic cancers

ckaakn-peptide-conjugated-long-circulating-nanoliposomes-for-the-targeted-delivery-of-oridonin-to-pancreatic-cancers
CKAAKN peptide-conjugated long-circulating nanoliposomes for the targeted delivery of oridonin to pancreatic cancers

Data availability

All data generated or analysed during this study are included in this published article (and its Supplementary Information files).

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Funding

The research was supported by grants from the National Natural Science Foundation of China (82360852). Guizhou Province Graduate Student Research Fund Project (QiankeheYJSKYJJ[2021]171). Shaoxing Science and Technology Planning Project (2023A14013). Science and Technology Program of Guizhou Province (Qiankehe Basics ZK [2023] Key 046). Natural Science Research Project of Guizhou Department of Education (Qianjiaoji [2023] 069). High-level Innovative Talents of Guizhou Province (QianKeHe platform talents-GCC [2023] 047). Guizhou Province Innovation Talent Team Construction (Platform Talent-CXTD[2023]020). The State Administration of Traditional Chinese Medicine high-level key discipline construction project (zyyzdxk-2023185). Guizhou Key Laboratory of Modern Traditional Chinese Medicine Creation (Qian Ke He Platform ZSYS [2025] 019).Nano-drug Technology Research Center of Guizhou University of Traditional Chinese Medicine (Guizhongyi ZX Hezi [2024] 070).

Author information

Author notes

  1. Fangxia Zhang and Kunshun Luo have contributed equally to this work.

Authors and Affiliations

  1. College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, China

    Fangxia Zhang, Kunshun Luo, Teng Chen, Zhiyong Chen, Jing Yang, Ying Zhou, Tingting Feng, Yue Zhu & Zuhua Wang

  2. Guizhou Key Laboratory of Modern Traditional Chinese Medicine Creation, Guiyang, China

    Fangxia Zhang, Kunshun Luo, Teng Chen, Zhiyong Chen, Jing Yang, Tingting Feng, Yue Zhu & Zuhua Wang

  3. Department of Pharmacy, Shaoxing People’s Hospital, Zhongxing North Road 568, Shaoxing, 312000, China

    Shaoyan Xuan

Authors

  1. Fangxia Zhang
  2. Kunshun Luo
  3. Shaoyan Xuan
  4. Teng Chen
  5. Zhiyong Chen
  6. Jing Yang
  7. Ying Zhou
  8. Tingting Feng
  9. Yue Zhu
  10. Zuhua Wang

Contributions

Kunshun Luo: Writing—original draft, Visualization, Conceptualization, Formal Analysis, Visualization, Review and Editing, Funding Acquisition; Fangxia Zhang: Writing-original draft, Visualization, Conceptualization, Formal Analysis, Visualization, Review and Editing; Teng Chen: Formal Analysis; Zhiyong Chen: Conceptualization, Formal Analysis; Jing Yang: Conceptualization; Ying Zhou: Funding Acquisition, Project Administration, Resources; Shaoyan Xuan: Funding Acquisition, Project Administration, Resources; Tingting Feng: Funding Acquisition, Project Administration, Resources; Yue Zhu: Conceptualization, project Administration, Resources, Formal Analysis; Zuhua Wang: Funding Acquisition, Project Administration, Resources, Conceptualization, Review and Editing.

Corresponding authors

Correspondence to Tingting Feng, Yue Zhu or Zuhua Wang.

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Competing interests

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Institutional review board statement

All experimental procedures presented in this manuscript were approved and carried out in accordance with the China Veterinary Animal Care Office Animal Experimental Ethics Committee of Guizhou University of Traditional Chinese Medicine (Grant No.20230022). This study was reported in accordance with ARRIVE guidelines.

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Zhang, F., Luo, K., Xuan, S. et al. CKAAKN peptide-conjugated long-circulating nanoliposomes for the targeted delivery of oridonin to pancreatic cancers. Sci Rep (2026). https://doi.org/10.1038/s41598-026-36920-5

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  • DOI: https://doi.org/10.1038/s41598-026-36920-5

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