References
-
Wang L, Lu B, He M, Wang Y, Wang Z, Du L. Prostate cancer incidence and mortality: global status and temporal trends in 89 countries from 2000 to 2019. Front Public Health. 2022;10:811044.
-
Alwanian WM, Tyner AL. Protein tyrosine kinase 6 signaling in prostate cancer. Am J Clin Exp Urol. 2020;8:1–8.
-
Chuu CP, Kokontis JM, Hiipakka RA, Fukuchi J, Lin HP, Lin CY, et al. Androgen suppresses proliferation of castration-resistant LNCaP 104-R2 prostate cancer cells through androgen receptor, Skp2, and c-Myc. Cancer Sci. 2011;02:2022–8.
-
Wozniak DJ, Hitchinson B, Gilic MB, Bie W, Gaponenko V, Tyner AL. Vemurafenib inhibits active PTK6 in PTEN-null prostate tumor cells. Mol Cancer Ther. 2019;18:937–46.
-
Ahmed NA, Mohyeldin MM, Ebrahim HY, McGehee OC, Tarun MTI, El Sayed KA. (−)-Oleuropein as a novel metastatic castration-resistant prostate cancer progression and recurrence suppressor via targeting PCSK9-LDLR Axis. Nutrients. 2025;17:1445.
-
Zheng Y, Tyner AL. Context-specific protein tyrosine kinase 6 (PTK 6) signalling in prostate cancer. Eur J Clin Investig. 2013;43:397–404.
-
Kasprzycka M, Majewski M, Wang Z-J, Ptasznik A, Wysocka M, Zhang Q, et al. Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes. Am J Pathol. 2006;168:1631–41.
-
Ang HL, Yuan Y, Lai X, Tan TZ, Wang L, Huang BB, et al. Putting the BRK on breast cancer: From molecular target to therapeutics. Theranostics. 2021;11:1115–28.
-
Liu L, Gao Y, Qiu H, Miller W, Poli V, Reich N. Identification of STAT3 as a specific substrate of breast tumor kinase. Oncogene. 2006;25:4904–12.
-
Zheng Y, Gierut J, Wang Z, Miao J, Asara JM, Tyner AL. Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT. Oncogene. 2013;32:4304–12.
-
Zhang C, Yang Z, Qin X, Ma J, Sun C, Huang H, et al. Genome mining for mycemycin: discovery and elucidation of related methylation and chlorination biosynthetic chemistries. Org Lett. 2018;20:7633–36.
-
Hunziker vF, Künzle F, Schindler O, Schmutz J. Dibenzo-azepine,-diazepine,-Oxazepine und-thiazepine. 3. Mitteilung über siebengliedrige Heterocyclen. Helv Chim Acta. 1964;47:1163–72.
-
Shen C, Neumann H, Wu X-F. A highly-efficient palladium-catalyzed aminocarbonylation/SN Ar approach to dibenzoxazepinones. Green Chem. 2015;17:2994–9.
-
Sapegin AV, Sakharov VN, Kalandadze LS, Smirnov AV, Khristolyubova TA, Plakhtinskii VV, et al. Synthesis of dibenzo [b, f][1, 4] oxazepin-11 (10H)-one and pyrido [2, 3-b][1, 4] benzoxazepin-10 (11H)-one compounds based on O-nitrochloro derivatives of benzene and pyridine. Mendeleev Commun. 2008;5:281–3.
-
Anchan K, Baburajan P, Puttappa NH, Kumar Sarkar S. One-pot synthesis of substituted dibenzoxazepinones and pyridobenzoxazepinones using octacarbonyldicobalt as an effective CO source. Synth Commun. 2020;50:348–60.
-
Azad I, Anand P, Ahmad N, Hassan F, Faiyyaz M, Akhter Y. Determination of anticancer activity and mechanism of action of benzooxazepines (BZOs) derivatives using multipronged computational and structural approaches. Chem Phys. 2024;581:112243.
-
Liu N, Song F, Shang F, Huang Y. Mycemycins A–E, new dibenzoxazepinones isolated from two different Streptomycetes. Mar Drugs. 2015;13:6247–58.
-
Liu W, Ma L, Zhang L, Chen Y, Zhang Q, Zhang H, et al. Two new phenylhydrazone derivatives from the Pearl River Estuary sediment-derived Streptomyces sp. SCSIO 40020. Mar Drugs. 2022;20:449.
-
Fiorentino A, D’Abrosca B, Pacifico S, Cefarelli G, Uzzo P, Monaco P. Natural dibenzoxazepinones from leaves of Carex distachya: Structural elucidation and radical scavenging activity. Bioorg Med Chem Lett. 2007;17:636–9.
-
Dhakal D, Pokhrel AR, Shrestha B, Sohng JK. Marine rare actinobacteria: isolation, characterization, and strategies for harnessing bioactive compounds. Front Microbiol. 2017;8:1106.
-
Thiemann J, Pagani H, Beretta G. A new genus of the Actinoplanaceae: Dactylosporangium, gen. nov. Arch Mikrobiol. 1967;58:42–52.
-
Wellis JS, O’Sullivan J, Aklonis C, Ax HA, Tymiak AA, Kirsch DR, et al. Dactylocyclines, novel tetracycline derivatives produced by a Dactylosporangium sp. I. Taxonomy, production, isolation and biological activity. J Antibiot. 1992;45:1892–8.
-
Satoi S, Awata M, Muto N, Hayashi M, Sagai H, Otani M. A new aminoglycoside antibiotic G-367 S1, 2’-N-formylsisomicin fermentation, isolation and characterization. J Antibiot. 1983;36:1–5.
-
Theriault RJ, Karwowski JP, Jakson M, Girolami RL, Sunga GN, Votko CM, et al. Tiacumicins, a novel complex of 18-membered macrolide antibiotics I. Taxonomy, fermentation and antibacterial activity. J Antibiot. 1987;40:567–74.
-
Elsbaey M, Jomori T, Tanaka J, Oku N, Igarashi Y. Okichromanone, a new antiviral chromanone from a marine-derived Microbispora. J Antibiot. 2024;77:389–92.
-
Elsbaey M, Samaru Y, Elekhnawy E, Oku N, Igarashi Y. A new polycyclic tetramate macrolactam from Allostreptomyces RD068384: stereochemistry and antifungal potential. J Antibiot. 2024;77:393–6.
-
Binaschi M, Boldetti A, Gianni M, Maggi CA, Gensini M, Bigioni M, et al. Antiproliferative and differentiating activities of a novel series of histone deacetylase inhibitors. ACS Med Chem Lett. 2010;1:411–5.
-
Foudah AI, Jain S, Busnena BA, El Sayed KA. Optimization of marine triterpene sipholenols as inhibitors of breast cancer migration and invasion. ChemMedChem. 2013;8:497–510.
-
Foudah AI, Sallam AA, Akl MR, El Sayed KA. Optimization, pharmacophore modeling and 3D-QSAR studies of sipholanes as breast cancer migration and proliferation inhibitors. Eur J Med Chem. 2014;73:310–24.
-
Akl MR, Foudah AI, Ebrahim HY, Meyer SA, Sayed KAE. The marine-derived sipholenol A-4-O-3′,4′-dichlorobenzoate inhibits breast cancer growth and motility in vitro and in vivo through the suppression of Brk and FAK signaling. Mar Drugs. 2014;12:2282–304.
-
Siddique AB, Ebrahim HY, Tajmim A, King JA, Abdelwahed KS, Abd Elmageed ZY, et al. Oleocanthal attenuates metastatic castration-resistant prostate cancer progression and recurrence by targeting SMYD2. Cancers. 2022;14:3542.
-
Thakur MK, Birudukota S, Swaminathan S, Battula SK, Vadivelu S, Tyagi R, et al. Co-crystal structures of PTK6: With Dasatinib at 2.24 Å, with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70 Å resolution. Biochem Biophys Res Commun. 2017;482:1289–95.
-
Lietha D, Eck MJ. Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation. PLoS ONE. 2008;3:e3800.
-
Ceccarelli DFJ, Song HK, Poy F, Schaller MD, Eck MJ. Crystal structure of the FERM domain of focal adhesion kinase. J Biol Chem. 2006;281:252–9.
-
Asiri AM, Ali AAAA, Abu-Alghayth MH. Targeting breast cancer with dasatinib derivatives: a multi-parameter strategy to uncover potent lead compounds. Int J Pharma Investig. 2024;14:1260–72.
-
Bluemn EG, Coleman IM, Lucas JM, Coleman RT, Hernandez-Lopez S, Tharakan R, et al. Androgen receptor pathway-independent prostate cancer is sustained through FGF signaling. Cancer Cell. 2017;32:474–89.
-
Mostaghel EA, Marck BT, Plymate SR, Vessella RL, Balk S, Matsumoto AM, et al. Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: induction of steroidogenesis and androgen receptor splice variants. Clin Cancer Res. 2011;17:5913–25.
-
Feyerabend S, Feil G, Krug J, Kassen A, Stenzl A. Cytotoxic effects of treosulfan on prostate cancer cell lines. Anticancer Res. 2007;27:2403–8.
-
Cattrini C, Capaia M, Boccardo F, Barboro P. Etoposide and topoisomerase II inhibition for aggressive prostate cancer: Data from a translational study. Cancer Treat Res Commun. 2020;25:100221.
-
Martin TA, Ye L, Sanders AJ, Lane J, Jiang WG. Cancer invasion and metastasis: molecular and cellular perspective. In: Madame Curie Bioscience Database. 2013. Available from: https://www.ncbi.nlm.nih.gov/books/NBK164700/.
-
Awasthi S, Gerke T, Park JY, Asamoah FA, Williams VL, Fink AK, et al. Optimizing time to treatment to achieve durable biochemical disease control after surgery in prostate cancer: a multi-institutional cohort study. Cancer Epidemiol Biomark Prev. 2019;28:570–7.
-
Zelefsky MJ, Eastham JA, Cronin AM, Fuks Z, Zhang Z, Yamada Y, et al. Metastasis after radical prostatectomy or external beam radiotherapy for patients with clinically localized prostate cancer: a comparison of clinical cohorts adjusted for case mix. J Clin Oncol. 2010;28:1508–13.
-
Damen MP, van Rheenen J, Scheele CL. Targeting dormant tumor cells to prevent cancer recurrence. FEBS J. 2021;288:6286–303.
-
Derry JJ, Prins GS, Ray V, Tyner AL. Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells. Oncogene. 2003;22:4212–20.
-
Miah S, Martin A, Lukong K. Constitutive activation of breast tumor kinase accelerates cell migration and tumor growth in vivo. Oncogenesis. 2012;1:e11.
-
Chen HY, Shen CH, Tsai YT, Lin FC, Huang YP, Chen RH. Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin. Mol Cell Biol. 2004;24:10558–72.
-
Al-Karmalawy AA, Mousa MHA, Sharaky M, Mourad MAE, El-Dessouki AM, Hamouda AO, et al. Lead optimization of BIBR1591 to improve its telomerase inhibitory activity: design and synthesis of novel four chemical series with in silico, in vitro, and in vivo preclinical assessments. J Med Chem. 2024;67:492–512.
-
Attia EZ, Khalifa BA, Shaban GM, Amin MN, Akil L, Khadra I, et al. Potential topoisomerases inhibitors from Aspergillus terreus using virtual screening. S Afr J Bot. 2022;149:632–45.
-
Elkamhawy A, Son S, Lee HY, El-Maghrabey MH, Hamd MAE, Alshammari SO, et al. Design, synthesis, biological evaluation, and molecular dynamics studies of novel lapatinib derivatives. Pharm. 2023;16:43.
-
Hussein ME, Mohamed OG, El-Fishawy AM, El-Askary HI, Hamed AA, Abdel-Aziz MM, et al. Anticholinesterase activity of budmunchiamine alkaloids revealed by comparative chemical profiling of two Albizia spp., molecular docking and dynamic studies. Plants. 2022;11:3286.
-
Guzman C, Bagga M, Kaur A, Westermarck J, Abankwa D. ColonyArea: an ImageJ plugin to automatically quantify colony formation in clonogenic assays. PLoS ONE. 2014;9:e92444.
