References
-
Hojsak, I. Probiotics in children: what is the evidence?. Pediatr. Gastroenterol. Hepatol. Nutr. 20, 139–146 (2017).
-
Woodhams, L. & Al-Salami, H. The roles of bile acids and applications of microencapsulation technology in treating Type 1 diabetes mellitus. Ther. Deliv. 8, 401–409 (2017).
-
Xu, Y., Zhang, T. & Xia, L. Effects of Lactiplantibacillus plantarum JBP3 and Limosilactobacillus reuteri JBR3 on the quality of beef jerky. Sci. Technol. Food Ind. 1–14 (2024).
-
Lee, B. S. et al. Safety assessment of Lactobacillus reuteri IDCC 3701based on phenotypic and genomic analysis. Ann. Microbiol. 71, 1–6 (2021).
-
Jiang, J. et al. Limosilactobacillus reuteri regulating intestinal function: a review. Fermentation 9, 19 (2022).
-
Liu, H. Y. et al. Epithelial heat shock proteins mediate the protective effects of Limosilactobacillus reuteri in dextran sulfate sodium-induced colitis. Front. Immunol. 13, 865982 (2022).
-
Khalique, A. et al. Probiotics mitigating subclinical necrotic enteritis(SNE) as potential alternatives to antibiotics in poultry. AMB Express 10, 50 (2020).
-
Bender, M. J. et al. Dietary tryptophan metabolite released byintratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment. Cell 186, 1846–1862.e26 (2023).
-
Bernard, N. J. Probiotics boost immunotherapy. Nat. Immunol. 24, 732 (2023).
-
Wilkins, T. & Sequoia, J. Probiotics for gastrointestinal conditions: a summary of the evidence. Am. Fam. Physician 96, 170–178 (2017).
-
Wang, K. et al. Survivability of probiotics encapsulated in kelp nanocellulose/alginate microcapsules on microfluidic device. Food Res. Int. 160, 111723 (2022).
-
Mohamadzadeh, M., Fazeli, A. & Shojaosadati, S. A. Polysaccharides and proteins-based bionanocomposites for microencapsulation of probiotics to improve stability and viability in the gastrointestinal tract: a review. Int. J. Biol. Macromol. 259, 129287 (2024).
-
Maciel, G. M. et al. Microencapsulation of Lactobacillus acidophilus La-5 by spray-drying using sweet whey and skim milk as encapsulating materials. J. Dairy Sci. 97, 1991–1998 (2014).
-
Wang, L. et al. A physically cross-linked sodium alginate–gelatin hydrogel with high mechanical strength. ACS Appl. Polym. Mater. 3, 3197–3205 (2021).
-
Deng, L. et al. Calcium alginate-encapsulated propolis microcapsules: optimization, characterization, and preservation effects on postharvest sweet cherry. Int. J. Biol. Macromol. 282, 137473 (2024).
-
Anselmo, A. C. et al. Layer-by-layer encapsulation of probiotics for delivery to the microbiome. Adv. Mater. 28, 9486–9490 (2016).
-
Jiménez-Gómez C. P., Cecilia J. A. Chitosan: a natural biopolymer with a wide and varied range of applications. Molecules 25, 3981 (2020).
-
Divya, K., Smitha, V. & Jisha, M. S. Antifungal, antioxidant and cytotoxic activities of chitosan nanoparticles and its use as an edible coating on vegetables. Int. J. Biol. Macromol. 114, 572–577 (2018).
-
Wu, D. et al. Chitosan-based colloidal polyelectrolyte complexes for drug delivery: a review. Carbohydr. Polym. 238, 116126 (2020).
-
Jones, S. E. & Versalovic, J. Probiotic Lactobacillus reuteri biofilms produce antimicrobial and anti-inflammatory factors. BMC Microbiol. 9, 35 (2009).
-
Li, S. et al. Lactobacillus reuteri improves gut barrier function and affects diurnal variation of the gut microbiota in mice fed a high-fat diet. Food Funct. 10, 4705–4715 (2019).
-
Long, H. et al. The protective effect and immunomodulatory ability of orally administrated Lacticaseibacillus rhamnosus GG against Mycoplasma pneumoniae infection in BALB/c mice. PloS One 19, e0312318 (2024).
-
Yu, Z. et al. The role of potential probiotic strains Lactobacillus reuteri in various intestinal diseases: New roles for an old player. Front. Microbiol. 14, 1095555 (2023).
-
Peer, D. et al. Nanocarriers as an emerging platform for cancer therapy. Nat. Nanotechnol. 2, 751–760 (2007).
-
Torchilin, V. P. Targeted pharmaceutical nanocarriers for cancer therapy and imaging. AAPS J. 9, E128–E147 (2007).
-
Jo, J. & Tabata, Y. How controlled release technology can aid gene delivery. Expert Opin. Drug Deliv. 12, 1689–1701 (2015).
-
Kanamala, M. et al. Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: a review. Biomaterials 85, 152–167 (2016).
-
Bae, Y. H. & Park, K. Targeted drug delivery to tumors: myths, reality and possibility. J. Control. Release 153, 198–205 (2011).
-
Shi, T. ongrui, Cui, Y. uchao & Wang, L. ikun Effecting factors of the formation and encapsulation efficiency of chitosan-alginate sodium microencapsules. J. Anim. Sci. Vet. Med. 38, 52–55 (2019).
-
Tan, P. Y. et al. Pickering emulsion-templated ionotropic gelation of tocotrienol microcapsules: effects of alginate and chitosan concentrations and gelation process parameters. J. Sci. food Agric. 101, 5963–5971 (2021).
-
Xiang, Z. henghao, Zhou, H. ualan & Zhang, J. iangguo Preparation of sodium alginate microcapsules and their application in microbial embedding. Ind. Microorg. 51, 43–49 (2021).
-
Rahman, Z. et al. Characterization of 5-fluorouracil microspheres for colonic delivery. AAPS PharmSciTech 7, E47 (2006).
-
Hongxia gao. Construction of probiotic delivery system and its gastrointestinal environment protection [Thesis], (2023).
-
Ahl, D. et al. Lactobacillus reuteri increases mucus thickness and ameliorates dextran sulphate sodium-induced colitis in mice. Acta Physiol. 217, 300–310 (2016).
-
Vijayaganapathi, A. & Mohanasrinivasan, V. A review of next-generation probiotics-as a gateway to biotherapeutics. Probiotics Antimicrob. Proteins 17, 1985–1997 (2025).
-
Chinese Pharmacopoeia Commission. Pharmacopoeia of the People’s Republic of China – Part IV. In. Beijing: China Medical Science and Technology Press; pp. 129-130 (2020).
-
Ma, H. angyu, Zhang, S. hikai & Wu, P. eng Preparation and digestive tolerance of compound prebiotic microcapsules. Food Res. Dev. 44, 152–161 (2023).
-
George, M. & Abraham, T. E. Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan-a review. J. Control. Release 114, 1–14 (2006).
-
Yang, J. unjie, Hu, G. uangmin & Zhu, M. eifang The dissolution behavior of chitosan and its fiber research progress. Prog. Mater. China 33, 641–648+689 (2014).
-
Donati, I. & Christensen, B. E. Alginate-metal cation interactions: macromolecular approach. Carbohydr. Polym. 321, 121280 (2023).
-
Guangyu Ren. Preparation of probiotic dual strain microcapsules and their mechanism of alleviating bacterial enteritis [Thesis]; (2022).
-
Yang, S. unqin, Ge, W. ei & Zhang, L. eichang The effect of gold juice fecal microbiota transplantation on disease activity index and inflammatory response in mice with damp heat ulcerative colitis. Drug Eval. 20, 139–143 (2023).
-
Wenbing Hu. Genomic diversity of Clostridium perfringens and mechanism analysis of strain CCFM1204 in alleviating non-alcoholic fatty liver disease [Thesis]; (2022).
-
López-Aladid, R. et al. Determining the most accurate 16S rRNA hypervariable region for taxonomic identification from respiratory samples. Sci. Rep. 13, 3974 (2023).
