References
-
Ahire, S. A. et al. The Augmentation of nanotechnology era: A concise review on fundamental concepts of nanotechnology and applications in material science and technology. Res. Chem. 4, 100633. https://doi.org/10.1016/j.rechem.2022.100633 (2022).
-
Khan, I., Saeed, K. & Khan, I. Nanoparticles: Properties, applications and toxicities. Arabian J. Chem. 12, 908–931. https://doi.org/10.1016/j.arabjc.2017.05.011 (2019).
-
Bayda, S., Adeel, M., Tuccinardi, T., Cordani, M. & Rizzolio, F. The history of nanoscience and nanotechnology: From chemical–physical applications to nanomedicine. Molecules 25(1), 112. https://doi.org/10.3390/molecules25010112 (2019).
-
Bhardwaj, B., Singh, P., Kumar, A., Kumar, S. & Budhwar, V. Eco-friendly greener synthesis of nanoparticles. Adv. Pharmaceut. Bull. 10, 566–576. https://doi.org/10.34172/apb.2020.067 (2020).
-
Sukhanova, A. et al. Dependence of nanoparticle toxicity on their physical and chemical properties. Nanoscale Res. Lett. 13(1), 44. https://doi.org/10.1186/s11671-018-2457-x (2018).
-
Rathod, S., Preetam, S., Pandey, C. & Bera, S. P. Exploring synthesis and applications of green nanoparticles and the role of nanotechnology in wastewater treatment. Biotechnol. Rep. 41, e00830. https://doi.org/10.1016/j.btre.2024.e00830 (2024).
-
Barhoum, A. et al. Review on natural, incidental, bioinspired, and engineered nanomaterials: history, definitions, classifications, synthesis, properties, market, toxicities, risks, and regulations. Nanomaterials 12, 177 (2022).
-
Xia, Y., Campbell, C. T., Roldan Cuenya, B. & Mavrikakis, M. Introduction: Advanced materials and methods for catalysis and electrocatalysis by transition metals. Chem. Rev. 121, 563–566. https://doi.org/10.1021/acs.chemrev.0c01269 (2021).
-
Baig, N., Kammakakam, I., Falath, W. & Kammakakam, I. Nanomaterials: A review of synthesis methods, properties, recent progress, and challenges. Mater. Adv. 2, 1821–1871. https://doi.org/10.1039/d0ma00807a (2021).
-
Altammar, K. A. A review on nanoparticles: characteristics, synthesis, applications, and challenges. Front. Microbiol. 14, 1155622. https://doi.org/10.3389/fmicb.2023.1155622 (2023).
-
Kumar, R. et al. Nanotoxicity unveiled: Evaluating exposure risks and assessing the impact of nanoparticles on human health. J. Trace Elements Minerals 13, 100252. https://doi.org/10.1016/j.jtemin.2025.100252 (2025).
-
Alshammari, B. H. et al. Organic and inorganic nanomaterials: Fabrication, properties and applications. RSC Adv. 13, 13735–13785. https://doi.org/10.1039/d3ra01421e (2023).
-
Nagaraja, S. K., Chakraborty, B., Bhat, M. P. & Nayaka, S. Biofabrication of nano-silver composites from Indian catmint-Anisomeles ovata flower buds extract and evaluation of their potential in-vitro biological applications. Pharmacol. Res. Natural Product. 7, 100246 (2025).
-
Hanna, D. H. et al. Plant-derived nanoparticles: Green synthesis, factors, and bioactivities. Next Mater. 9, 101275. https://doi.org/10.1016/j.nxmate.2025.101275 (2025).
-
Kulkarni, D. et al. Biofabrication of nanoparticles: Sources, synthesis, and biomedical applications. Front. Bioeng. Biotechnol. 11, 1159193. https://doi.org/10.3389/fbioe.2023.1159193 (2023).
-
Karunakaran, G., Sudha, K. G., Ali, S. & Cho, E. B. Biosynthesis of nanoparticles from various biological sources and its biomedical applications. Molecules 28(11), 4527. https://doi.org/10.3390/molecules28114527 (2023).
-
Pandit, C. et al. Biological agents for synthesis of nanoparticles and their applications. J. King Saud Univ. Sci. 34, 101869 (2022).
-
Azadpour, A. & Khaleghi, S. Biosynthesized nanoparticles in pharmaceutical and biomedical sciences: Recent advances. Mater. Today Commun. 41, 110741. https://doi.org/10.1016/j.mtcomm.2024.110741 (2024).
-
Kalpana, M. et al. Actinobacteria mediated synthesis of silver nanoparticles using Streptomyces diastaticus and their biological efficacy against human vector mosquitoes and agricultural insect pests. J. Nat. Pesticide Res. 10, 100091 (2024).
-
Cardoso, B., Nobrega, G., Afonso, I. S., Ribeiro, J. E. & Lima, R. A. Sustainable green synthesis of metallic nanoparticle using plants and microorganisms: A review of biosynthesis methods, mechanisms, toxicity, and applications. J. Environ. Chem. Eng. 13, 116921. https://doi.org/10.1016/j.jece.2025.116921 (2025).
-
El-Sheekh, M. M., Morsi, H. H., Hassan, L. H. S. & Ali, S. S. The efficient role of algae as green factories for nanotechnology and their vital applications. Microbiol. Res. 263, 127111. https://doi.org/10.1016/j.micres.2022.127111 (2022).
-
Adeleke, B. S. et al. Biosynthesis of nanoparticles using microorganisms: A focus on endophytic fungi. Heliyon. 10, e39636. https://doi.org/10.1016/j.heliyon.2024.e39636 (2024).
-
Moghaddam, A. B. et al. Nanoparticles biosynthesized by fungi and yeast: A review of their preparation, properties, and medical applications. Molecules 20, 16540–16565. https://doi.org/10.3390/molecules200916540 (2015).
-
Nyabadza, A. et al. A review of physical, chemical and biological synthesis methods of bimetallic nanoparticles and applications in sensing, water treatment, biomedicine, catalysis and hydrogen storage. Adv. Coll. Interface Sci. 321, 103010. https://doi.org/10.1016/j.cis.2023.103010 (2023).
-
Osman, A. I. et al. Synthesis of green nanoparticles for energy, biomedical, environmental, agricultural, and food applications: A review. Environ. Chem. Lett. 22, 841–887. https://doi.org/10.1007/s10311-023-01682-3 (2024).
-
Singh, H. et al. Revisiting the green synthesis of nanoparticles: Uncovering influences of plant extracts as reducing agents for enhanced synthesis efficiency and its biomedical applications. Int. J. Nanomed. 18, 4727–4750. https://doi.org/10.2147/IJN.S419369 (2023).
-
Ayub, A. et al. Green nanoscience for healthcare: Advancing biomedical innovation through eco-synthesized nanoparticle. Biotechnol. Rep. 47, e00913. https://doi.org/10.1016/j.btre.2025.e00913 (2025).
-
Kazemi, S. et al. Recent advances in green synthesized nanoparticles: From production to application. Mater. Today Sustain. 24, 100500. https://doi.org/10.1016/j.mtsust.2023.100500 (2023).
-
Sati, A., Ranade, T. N., Mali, S. N., Ahmad Yasin, H. K. & Pratap, A. Silver nanoparticles (AgNPs): Comprehensive insights into bio/synthesis, key influencing factors, multifaceted applications, and toxicity─ a 2024 update. ACS Omega 10(8), 7549–7582. https://doi.org/10.1021/acsomega.4c11045 (2025).
-
Mehra, V., Kumar, S., Tamang, A. M. & Chandraker, S. K. Green synthesis of gold nanoparticles (AuNPs) by using plant extract and their biological application: A review. BioNanoScience 15, 18. https://doi.org/10.1007/s12668-024-01703-7 (2025).
-
Kanwar, R., Rathee, J., Salunke, D. B. & Mehta, S. K. Green nanotechnology-driven drug delivery assemblies. ACS Omega 4, 8804–8815 (2019).
-
Malik, A. Q. et al. A review on the green synthesis of nanoparticles, their biological applications, and photocatalytic efficiency against environmental toxins. Environ. Sci. Pollut. Res. 30, 69796–69823. https://doi.org/10.1007/s11356-023-27437-9 (2023).
-
Ponnamma, D. et al. Green synthesized materials for sensor, actuator, energy storage and energy generation: A review. Polym. Plast. Technol. Mater. 59, 1–62 (2020).
-
Comito, R., Darbyshire, I., Kiel, C., McDade, L. & Fisher, A. E. A RADseq phylogeny of Barleria (Acanthaceae) resolves fine-scale relationships. Mol. Phylogenet. Evol. 169, 107428 (2022).
-
Gangaram, S., Naidoo, Y., Dewir, Y. H. & El-Hendawy, S. Phytochemicals and biological activities of barleria (Acanthaceae). Plants 11, 82. https://doi.org/10.3390/plants11010082 (2022).
-
Keomanykham, O. et al. Prionitosides A and B—two iridoid glycosides with anti-inflammatory and cytotoxic activities from Barleria prionitis. Phytochem. Lett. 60, 10–13 (2024).
-
Rodrigues, A. S. et al. Advances in silver nanoparticles: A comprehensive review on their potential as antimicrobial agents and their mechanisms of action elucidated by proteomics. Front. Microbiol. 15, 1440065. https://doi.org/10.3389/fmicb.2024.1440065 (2024).
-
Zhang, W. et al. Effects of morphology and size of nanoscale drug carriers on cellular uptake and internalization process: A review. RSC Adv. 13, 80–114. https://doi.org/10.1039/d2ra06888e (2022).
-
Shao, F. et al. Bio-synthesis of Barleria gibsoni leaf extract mediated zinc oxide nanoparticles and their formulation gel for wound therapy in nursing care of infants and children. J. Photochem. Photobiol. B 189, 267–273 (2018).
-
Mohsen Ali, S. S. & Robin, P. Comprehensive phytochemical profiling of bioactive compounds from Barleria prattensis for their antioxidant and cytotoxic capacity and its characterization using GC-MS. Biochem. Biophys. Rep. 43, 102083 (2025).
-
Shaikh, J. R. & Patil, M. Qualitative tests for preliminary phytochemical screening: An overview. Int. J. Chem. Stud. 8, 603–608 (2020).
-
Gwada, C. A. et al. Phytochemical-assisted synthesis, optimization, and characterization of silver nanoparticles for antimicrobial activity. RSC Adv. 15, 14170–14181 (2025).
-
Ali, S. S. M., Aljawobaei, W., Rao, V. J., Nagar, P. S. & Robin, P. Sustainable synthesis of silver nanoparticles using Barleria prattensis extract: Characterization and evaluation of their biological and catalytic activities. Biomass. Convers. Biorefin. 15, 17811–17828 (2025).
-
Ali, S. S. M., Dawale, A. M. A., Samal, S., Robin, P. & Thakore, S. Barleria grandiflora leaf extract-driven silver nanoparticles: Assessment of their antibacterial, cytotoxicity, and catalysis. ChemistrySelect 10, e00764 (2025).
-
Manzoor, S. I. et al. Green synthesis of biocompatible silver nanoparticles using Trillium govanianum rhizome extract: Comprehensive biological evaluation and in silico analysis. Mater. Adv. 6, 682–702 (2024).
-
Bin-Asal, F. S. N., Saeed, A. A. & Yahia, A. R. A. B. Corallocarpus glomeruliflorus: Pharmacological potential revealed by phytochemical and in silico investigations. Biochem. Biophys. Rep. 41, 101940 (2025).
-
Ansar, S. et al. Eco friendly silver nanoparticles synthesis by Brassica oleracea and its antibacterial, anticancer and antioxidant properties. Sci. Rep. 10, 18564 (2020).
-
Relva, M. et al. Electrophoretic deposition of green-synthesized hydroxyapatite on thermally oxidized titanium: enhanced bioactivity and antibacterial performance. Appl. Sci. 15, 8598 (2025).
-
Samal, S., Patel, M., Rohilla, A., Chandodwala, K. & Thakore, S. Sustainable synthesis of multifaceted copper oxide nanoparticles from Euphorbia tirucalli: Unveiling antimicrobial and catalytic potential. Mater. Sci. Eng. B 310, 117718 (2024).
-
Illanes Tormena, R. P. et al. Evaluation of the antimicrobial activity of silver nanoparticles obtained by microwave-assisted green synthesis using Handroanthus impetiginosus(Mart. ex DC.) Mattos underbark extract. RSC Adv. 10, 20676–20681 (2020).
-
Khan, S., Rukayadi, Y., Jaafar, A. H. & Ahmad, N. H. Antibacterial potential of silver nanoparticles (SP-AgNPs) synthesized from Syzygium polyanthum (Wight) Walp. against selected foodborne pathogens. Heliyon 9, (2023).
-
Bedlovičová, Z., Strapáč, I., Baláž, M. & Salayová, A. A brief overview on antioxidant activity determination of silver nanoparticles. Molecules 25, 3191. https://doi.org/10.3390/molecules25143191 (2020).
-
Ručová, D. et al. Photoprotective and antioxidant properties of scytonemin isolated from Antarctic cyanobacterium Nostoc commune Vaucher ex Bornet & Flahault and its potential as sunscreen ingredient. J. Appl. Phycol. 35, 2839–2850 (2023).
-
Aljawobaei, W., Thippeswamy, N. B., Ali, S. S. M. & Achur, R. Evaluation of in vitro anti-inflammatory and antioxidant activities of Simarouba glauca leaf extract. Plant Sci. Today 12, 1–9 (2025).
-
Diab, T. A., Donia, T. & Saad-Allah, K. M. Characterization, antioxidant, and cytotoxic effects of some Egyptian wild plant extracts. Beni Suef. Univ. J. Basic Appl. Sci. 10, 13 (2021).
-
Nagaraja, S. K., Niazi, S. K., Bepari, A., Assiri, R. A. & Nayaka, S. Leonotis nepetifolia flower bud extract mediated green synthesis of silver nanoparticles, their characterization, and in vitro evaluation of biological applications. Materials 15, 8990 (2022).
-
Soliman, M. K. Y., Salem, S. S., Abu-Elghait, M. & Azab, M. S. Biosynthesis of silver and gold nanoparticles and their efficacy towards antibacterial, antibiofilm, cytotoxicity, and antioxidant activities. Appl. Biochem. Biotechnol. 195, 1158–1183 (2023).
-
Eze, F. N., Tola, A. J., Nwabor, O. F. & Jayeoye, T. J. Centella asiatica phenolic extract-mediated bio-fabrication of silver nanoparticles: Characterization, reduction of industrially relevant dyes in water and antimicrobial activities against foodborne pathogens. RSC Adv. 9, 37957–37970 (2019).
-
Hasan, K. M. F. et al. Functional silver nanoparticles synthesis from sustainable point of view: 2000 to 2023—A review on game changing materials. Heliyon 8, e12322. https://doi.org/10.1016/j.heliyon.2022.e12322 (2022).
-
Javed, R. et al. Role of capping agents in the application of nanoparticles in biomedicine and environmental remediation: recent trends and future prospects. J. Nanobiotechnol. 18, 172. https://doi.org/10.1186/s12951-020-00704-4 (2020).
-
Arshad, F. et al. Bioinspired and green synthesis of silver nanoparticles for medical applications: A green perspective. Appl. Biochem. Biotechnol. 196, 3636–3669. https://doi.org/10.1007/s12010-023-04719-z (2024).
-
Ahmed, S., Ahmad, M., Swami, B. L. & Ikram, S. A review on plants extract mediated synthesis of silver nanoparticles for antimicrobial applications: A green expertise. J. Adv. Res. 7, 17–28. https://doi.org/10.1016/j.jare.2015.02.007 (2016).
-
Ayyankalai, N. K. et al. Green production of silver nanoparticles from Cassia occidentalis and Alternanthera pungens and evaluation of their nematicidal activity against Meloidogyne javanica. Sci. Rep. 15, 26228 (2025).
-
Rudrappa, M. et al. Plumeria alba-Mediated green synthesis of silver nanoparticles exhibits antimicrobial effect and anti-oncogenic activity against glioblastoma U118 MG cancer cell line. Nanomaterials 12, 493 (2022).
-
Peng, H. et al. Reduction of silver ions to silver nanoparticles by biomass and biochar: Mechanisms and critical factors. Sci. Total Environ. 779, 146326 (2021).
-
Tural, B., Ertaş, E., Batıbay, H. & Tural, S. The Impact of Pistacia khinjuk plant gender on silver nanoparticle synthesis: Are extracts of root obtained from female plants preferentially used?. Biochem. Biophys. Res. Commun. 746, 151257 (2025).
-
Chandraker, S. K. et al. Therapeutic potential of biogenic and optimized silver nanoparticles using Rubia cordifolia L. leaf extract. Sci. Rep. 12, 8831 (2022).
-
Pasieczna-Patkowska, S., Cichy, M. & Flieger, J. Application of Fourier transform infrared (FTIR) spectroscopy in characterization of green synthesized nanoparticles. Molecules 30, 684. https://doi.org/10.3390/molecules30030684 (2025).
-
Chandraker, S. K., Lal, M. & Shukla, R. DNA-binding, antioxidant, H2O2 sensing and photocatalytic properties of biogenic silver nanoparticles using: Ageratum conyzoides L. leaf extract. RSC Adv. 9, 23408–23417 (2019).
-
Gunagambhire, P. V., Rudrappa, M. & Nayaka, S. Myco-nanofabrication of silver nanoparticles from Clonostachys byssicola PSEF1: Characterization, and exploration of its antimicrobial, antioxidant, anti-diabetic, anti-inflammatory and anticancer property on liver cancer cells. Biochem. Biophys. Res. Commun. 781, 152544 (2025).
-
Barabadi, H. et al. Trametes versicolor laccase-derived silver nanoparticles: Green synthesis, structural characterization and multifunctional biological properties. Biochem. Biophys. Res. Commun. 740, 150995 (2024).
-
Qing, Y. et al. Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies. Int. J. Nanomed. 13, 3311–3327. https://doi.org/10.2147/IJN.S165125 (2018).
-
Hu, X. L. et al. Low-dimensional nanomaterials for antibacterial applications. J. Mater. Chem. B 9(17), 3640–3661. https://doi.org/10.1039/d1tb00033k (2021).
-
Elmehalawy, N. G., Zaky, M. M. M., Eid, A. M. & Fouda, A. Eco-friendly synthesis of silver nanoparticles: Multifaceted antioxidant, antidiabetic, anticancer, and antimicrobial activities. Sci. Rep. 15, 37349 (2025).
-
De Mel, S. et al. Green synthesis of silver nanoparticles using Magnolia alba leaf extracts and evaluating their antimicrobial, anticancer, antioxidant, and photocatalytic properties. Sci. Rep. 15, 23709 (2025).
-
Remya, R. R., Rajasree, S. R. R., Aranganathan, L. & Suman, T. Y. An investigation on cytotoxic effect of bioactive AgNPs synthesized using Cassia fistula flower extract on breast cancer cell MCF-7. Biotechnol. Rep. 8, 110–115 (2015).
-
Majeed, S., Bakhtiar, N. F. B., Danish, M., Mohamad Ibrahim, M. N. & Hashim, R. Green approach for the biosynthesis of silver nanoparticles and its antibacterial and antitumor effect against osteoblast MG-63 and breast MCF-7 cancer cell lines. Sustain. Chem. Pharm. 12, 100138 (2019).
-
Kavipriya, M., Selleswari, D. & Rajaganesh, R. Chitosan encapsulated silver nanoparticles by Brassica oleracea leaf extract: An in-vitro antioxidant, antimicrobial and anticancer activity on breast cancer MCF-7. Chem. Africa 7, 4875–4892 (2024).
-
Madakka, M., Jayaraju, N. & Rajesh, N. Evaluating the antimicrobial activity and antitumor screening of green synthesized silver nanoparticles compounds, using Syzygium jambolanum, towards MCF7 cell line (Breast cancer cell line). J. Photochem. Photobiol. 6, 100028 (2021).
-
Ahmad, T. et al. Biosynthesis, characterization and photo-catalytic degradation of methylene blue using silver nanoparticles. Mater. Today Proceed. 29, 1039–1043 (2020).
-
Saha, J., Begum, A., Mukherjee, A. & Kumar, S. A novel green synthesis of silver nanoparticles and their catalytic action in reduction of Methylene Blue dye. Sustain. Environ. Res. 27, 245–250 (2017).
-
Somasundaram, C. K. et al. Sustainable synthesis of silver nanoparticles using marine algae for catalytic degradation of methylene blue. Catalysts 11, 1377 (2021).
