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Authors and Affiliations

1. Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, Columbia University, New York City, NY, USA

   Richard Pan, Jingwei Ren, Xinyue Chen, Luis F. Flores, Rachel V. L. Gonzalez, Andre Antonio Adonnino & X. Shawn Liu

2. Fred Hutchinson Cancer Center, Seattle, WA, USA

   Brandon Lofts

3. Department of Neurology, New York University Langone Comprehensive Epilepsy Center, NYU Langone Health, New York, NY, USA

   Jennifer Waldo, Julian Halmai & Kyle Fink

4. Department of Neurology, University of California Davis School of Medicine, Sacramento, CA, USA

   Orrin Devinsky

Contributions

R.P. and X.S.L. conceived the idea for this project. R.P. and X.S.L. designed the experiments. R.P., J.R., X.C., L.F.F., R.V.L.G., A.A.A., and X.S.L. performed the experiments. B.L. cultured and provided the Mecp2 reporter cells. J.W. and J.H. packaged AAV9 virus. R.P., O.D., K.F., and X.S.L. interpreted the data, and wrote the manuscript with input from all the other authors.

Corresponding author

Correspondence to X. Shawn Liu.

Competing interests

O.D. has equity in Epitor Therapeutics, Regel Therapeutics, Ajna Biosciences, Blackrock Neurotech, ConnectRN, Tevard Therapeutics, and PhiFund Ventures. K.F. is a SAB member for Epitor Therapeutics. X.S.L. is a co-founder of Epitor Therapeutics. The remaining authors declare no competing interests.

Peer review information

Nature Communications thanks Takuro Horii and the other anonymous, reviewer(s) for their contribution to the peer review of this work. A peer review file is available.

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