Endometrium-targeted mRNA-lipid nanoparticles for treating reproductive conditions

endometrium-targeted-mrna-lipid-nanoparticles-for-treating-reproductive-conditions
Endometrium-targeted mRNA-lipid nanoparticles for treating reproductive conditions
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Nature Nanotechnology (2026)Cite this article

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Dysfunctions of the endometrium can impair the first stage of pregnancy: embryo implantation. We developed a strategy to deliver therapeutic mRNA to the endometrium with high specificity using a ligand-conjugated mRNA- lipid nanoparticle, restoring implantation rates in a murine model of endometrial injury with improved safety profiles.

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Fig. 1: Targeted mRNA-LNP in the endometrium restores fertility rates in mice.

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This is a summary of: Abbasi, S. et al. Spatiotemporal targeting of messenger RNA lipid nanoparticles to the endometrium for the treatment of reproductive disorders. Nat. Nanotechnol. https://doi.org/10.1038/s41565-025-02108-7 (2026).

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Endometrium-targeted mRNA-lipid nanoparticles for treating reproductive conditions. Nat. Nanotechnol. (2026). https://doi.org/10.1038/s41565-025-02116-7

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  • DOI: https://doi.org/10.1038/s41565-025-02116-7