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Dysfunctions of the endometrium can impair the first stage of pregnancy: embryo implantation. We developed a strategy to deliver therapeutic mRNA to the endometrium with high specificity using a ligand-conjugated mRNA- lipid nanoparticle, restoring implantation rates in a murine model of endometrial injury with improved safety profiles.
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References
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Musunuru, K. et al. Patient-specific in vivo gene editing to treat a rare genetic disease. N. Engl. J. Med. 392, 2235–2243 (2025). A clinical study that demonstrates the promise of mRNA-LNP in delivering safe and effective cures in neonates.
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Swingle, K. L. et al. Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia. Nature 637, 412–421 (2025). This paper reports the treatment of a life-threatening pregnancy-related disorder using an mRNA-LNP technology.
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Lessey, B. A. et al. Integrin adhesion molecules in the human endometrium. Correlation with the normal and abnormal menstrual cycle. J. Clin. Invest. 90, 188–195 (1992). An article showing that integrin receptors are cyclically regulated and overexpressed on the endometrium during the WOI.
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This is a summary of: Abbasi, S. et al. Spatiotemporal targeting of messenger RNA lipid nanoparticles to the endometrium for the treatment of reproductive disorders. Nat. Nanotechnol. https://doi.org/10.1038/s41565-025-02108-7 (2026).
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Endometrium-targeted mRNA-lipid nanoparticles for treating reproductive conditions. Nat. Nanotechnol. (2026). https://doi.org/10.1038/s41565-025-02116-7
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DOI: https://doi.org/10.1038/s41565-025-02116-7
