Ratner BD, Hoffman AS, Schoen FJ, Lemons JE, editors. Biomaterials Science: An Introduction to Materials in Medicine. 3rd ed. Amsterdam: Academic Press/Elsevier; 2012.
Brash JL, Horbett TA, Latour RA, Tengvall P. The blood compatibility challenge. Part 2: Protein adsorption phenomena governing blood reactivity. Acta Biomater. 2019;94:11–24.
Ishihara K. Biomimetic polymers with phosphorylcholine groups as biomaterials for medical devices. Proc Jpn Acad Ser B. 2024;100:579–606.
Tsuruta T. On the role of water molecules in the interface between biological systems and polymers in special issue on the occasion of the 90th birthday of Prof. T. Tsuruta. J Biomater Sci Polym Ed. 2010;21:1827–48.
Tanaka M, Motomura T, Kawada M, Anzai T, Kasori Y, Shiroya T, et al. Blood compatible aspects of poly(2-methoxyethyl acrylate) (PMEA): Relationship between protein adsorption and platelet adhesion on PMEA surface. Biomaterials. 2000;21:1471–81.
Tanaka M, Mochizuki A. Clarification of the Blood Compatibility Mechanism by Controlling the Water Structure at the Blood-Poly(meth)acrylate Interface. J Biomater Sci Polym Ed. 2010;21:1849–63.
Tanaka M, Sato K, Kitakami E, Kobayashi S, Hoshiba T, Fukushima K. Design of biocompatible and biodegradable polymers based on intermediate water concept. Polym J. 2015;47:114–21.
Tanaka M, Kobayashi S, Murakami D, Aratsu F, Kashiwazaki A, Hoshiba T, et al. Design of Polymeric Biomaterials: The “Intermediate Water Concept. Bull Chem Soc Jpn. 2019;92:2043–57.
Dargaville BL, Hutmacher DW. Water as the often neglected medium at the interface between materials and biology. Nat Commun. 2022;13:4222–31.
Bruck SD. Aspects of three types of hydrogels for biomedical applications. J Biomed Mater Res. 1973;7:387–404.
Andrade JD, Lee HB, Kim JhonMS, Hibbs SW. JB Jr. Water as a biomaterial. Trans Am Soc Artif Intern Organs. 1973;19:1–7.
Ratner BD, Hoffman AS, Hanson SR, Harker LA, Whiffen JD. Blood-compatibility–water-content relationships for radiation-grafted hydrogels. J Polym Sci Polym Symp. 1979;66:363–75.
Yamada-Nosaka A, Ishikiriyama K, Todoki M, Tanzawa H. 1H-NMR studies on water in methacrylate hydrogels. J Appl Polym Sci. 1990;39:2443–52.
Lu DR, Lee SJ, Park K. Calculation of solvation interaction energies for protein adsorption on polymer surfaces. J Biomater Sci Polym Ed. 1992;3:127–47.
Israelachvili J, Wennerström H. Role of hydration and water structure in biological and colloidal interactions. Nature. 1996;379:219–25.
Feldman K, Hähner G, Spencer ND, Harder P, Grunze M. Probing resistance to protein adsorption of oligo(ethylene glycol)-terminated self-assembled monolayers by scanning force microscopy. J Am Chem Soc. 1999;121:10134–41.
Kataoka K, Ito H, Amano H, Nagasaki Y, Kato M, Tsuruta T, et al. Minimized platelet interaction with poly(2-hydroxyethyl methacrylate-block-4-bis(trimethylsilyl)methylstyrene) hydrogel showing anomalously high free water content. J Biomater Sci Polym Ed. 1998;9:111–29.
Ishihara K, Nomura H, Mihara T, Kurita K, Iwasaki Y, Nakabayashi N. Why do phospholipid polymers reduce protein adsorption? J Biomed Mater Res. 1998;39:323–30.
Morisaku T, Watanabe J, Konno T, Takai M, Ishihara K. Hydration of phosphorylcholine groups attached to highly swollen polymer hydrogels studied by thermal analysis. Polymer. 2008;49:4652–7.
Tanaka M, Mochizuki A, Ishii N, Motomura T, Hatakeyama T. Study of blood compatibility with poly(2-methoxyethyl acrylate): Relationship between water structure and platelet compatibility in poly(2-methoxyethyl acrylate-co-2-hydroxyethyl methacrylate). Biomacromolecules. 2002;3:36–41.
Tanaka M, Mochizuki A. Effect of water structure on blood compatibility: Thermal analysis of water in poly(meth)acrylate. J Biomed Mater Res A. 2004;68:684–95.
Berglin M, Andersson M, Sellborn A, Elwing H. The effect of substrate molecular mobility on surface-induced immune complement activation and blood plasma coagulation. Biomaterials. 2004;25:4581–90.
Zheng J, Li L, Tsao H-K, Sheng Y-J, Chen S, Jiang S. Strong repulsive forces between protein and oligo(ethylene glycol) self-assembled monolayers: A molecular simulation study. Biophys J. 2005;89:158–66.
Seo J-H, Kakinoki S, Inoue Y, Nam K, Yamaoka T, Ishihara K, et al. The significance of hydrated surface molecular mobility in the control of the morphology of adhering fibroblasts. Biomaterials. 2013;34:3206–14.
Hatakeyama T, Kishi A, Tanaka M. Comparison of measurement techniques for the identification of bound water restrained by polymers. Thermochim Acta. 2012;532:159–63.
Shiomoto S, Inoue K, Higuchi H, Nishimura SN, Takaba H, Tanaka M, et al. Characterization of hydration water bound to choline phosphate-containing polymers. Biomacromolecules. 2022;23:2999–3008.
Kojima C, Suzuki Y, Ikemoto Y, Tanaka M, Matsumoto A. Comparative study of PEG and PEGylated dendrimers in their eutectic mixtures with water analyzed using X-ray diffraction and infrared spectroscopy. Polym J. 2023;55:63–73.
Miwa Y, Ishida H, Tanaka M, Mochizuki A. H-2-NMR and C-13-NMR study of the hydration behavior of poly(2-methoxyethyl acrylate), poly(2-hydroxyethyl methacrylate) and poly(tetrahydrofurfuryl acrylate) in relation to their blood compatibility as biomaterials. J Biomater Sci Polym Ed. 2010;21:1911–24.
Miwa Y, Ishida H, Saito H, Tanaka M, Mochizuki A. Network structures and dynamics of dry and swollen poly(acrylate)s. Characterization of high- and low-frequency motions as revealed by suppressed or recovered intensities (SRI) analysis of C-13 NMR. Polymer. 2009;50:6091–9.
Morita S, Tanaka M. Effect of sodium chloride on hydration structures of PMEA and P(MPC-r-BMA). Langmuir. 2014;30:10698–703.
Kitano H, Tada S, Mori T, Takaha K, Gemmei-Ide M, Tanaka M, et al. Correlation between the structure of water in the vicinity of carboxybetaine polymers and their blood-compatibility. Langmuir. 2005;21:11932–40.
Ikemoto Y, Harada Y, Tanaka M, Nishimura S-n, Murakami D, Kurahashi N, et al. Infrared spectra and hydrogen-bond configurations of water molecules at the interface of water-insoluble polymers under humidified conditions. J Phys Chem B. 2022;126:4143–51.
Saleh MA, Higuchi Y, Shiomoto S, Anada T, Hishida M, Tanaka M. Effect of zwitterionic monomer polymerization on water dynamics: a molecular dynamics simulation study supported by differential scanning calorimetry and terahertz spectroscopy. Polym J. 2025;57:1127–39.
Hishida M, Anjum R, Anada T, Murakami D, Tanaka M. Effect of osmolytes on water mobility correlates with their stabilizing effect on proteins. J Phys Chem B. 2022;126:2466–75.
Ye S, Morita S, Li G, Noda H, Tanaka M, Uosaki K, et al. Structural changes in poly(2-methoxyethyl acrylate) thin films induced by absorption of bisphenol A. An infrared and sum frequency generation (SFG) study. Macromolecules. 2003;36:5694–703.
Hirata T, Matsuno H, Kawaguchi D, Hirai T, Yamada NL, Tanaka M, et al. Effect of local chain dynamics on a bioinert interface. Langmuir. 2015;31:3661–7.
Hirata T, Matsuno H, Kawaguchi D, Yamada NL, Tanaka M, Tanaka K. Effect of interfacial structure on bioinert properties of poly(2-methoxyethyl acrylate)/poly(methyl methacrylate) blend films in water. Phys Chem Chem Phys. 2015;17:17399–405.
Hirata T, Matsuno H, Kawaguchi D, Yamada NL, Tanaka M, Tanaka K. Construction of a blood-compatible interface based on surface segregation in a polymer blend. Polymer. 2015;78:219–24.
Nishimura S-n, Kurahashi N, Shiomoto S, Harada Y, Tanaka M. Effects of hydration water on bioresponsiveness of polymer interfaces revealed by analysis of linear and cyclic polymer-grafted substrates. Soft Matter. 2024;20:9454–63.
Higaki Y, Masuda T, Shiomoto S, Tanaka Y, Kiuchi H, Harada Y, et al. Pronounced cold crystallization and hydrogen bonding distortion of water confined in microphases of double zwitterionic block copolymer aqueous solutions. Langmuir. 2024;40:19612–18.
Murakami D, Yamazoe K, Nishimura S-n, Kurahashi N, Ueda T, Miyawaki J, et al. Hydration mechanism in blood-compatible polymers undergoing phase separation. Langmuir. 2022;38:1090–98.
Hirata T, Matsuno H, Kawaguchi D, Inutsuka M, Hirai T, Tanaka M, et al. Dynamics of a bioinert polymer in hydrated states by dielectric relaxation spectroscopy. Phys Chem Chem Phys. 2017;19:1389–94.
Kanamaru T, Araki M, Takahashi R, Fujii S, Shikata T, Murakami D, et al. First observation of the hydration layer around polymer chain by scattering and its relationship to thromboresistance: dilute solution properties of PMEA in THF/water. J Phys Chem B. 2021;125:7251–61.
Nakada M. Low-temperature behaviors, cold crystallization, and glass transition in poly(vinylpyrrolidone) aqueous solution. J Phys Chem B. 2023;127:10556–63.
Kishi A, Tanaka M, Mochizuki A. Comparative study on water structures in polyHEMA and polyMEA by XRD-DSC simultaneous measurement. J Appl Polym Sci. 2009;111:476–81.
Fujii Y, Tominaga T, Murakami D, Tanaka M, Seto H. Local dynamics of the hydration water and poly(methyl methacrylate) chains in PMMA networks. Front Chem. 2021;9:728738.
Kikuchi T, Tominaga T, Murakami D, de Souza NR, Tanaka M, Seto H. Detailed dynamical features of the slow hydration water in the vicinity of poly(ethylene oxide) chains. J Chem Phys. 2024;160:064902.
Tominaga T, Hishida M, Murakami D, Fujii Y, Tanaka M, Seto H. Experimental evidence of slow mode water in the vicinity of poly(ethylene oxide) at physiological temperature. J Phys Chem B. 2022;126:1758–67.
Higaki Y, Toyama H, Masuda T, Kobayashi S, Tanaka M. Microphase separation of double-hydrophilic poly(carboxybetaine acrylate)-poly(2-methoxyethyl acrylate) block copolymers in water. Polym J. 2023;55:1357–65.
Hayashi T, Tanaka Y, Koide Y, Tanaka M, Hara M. Mechanism underlying bioinertness of self-assembled monolayers of oligo(ethyleneglycol)-terminated alkanethiols on gold: Protein adsorption, platelet adhesion, and surface forces. Phys Chem Chem Phys. 2012;14:10196–206.
Nishida K, Anada T, Tanaka M. Roles of interfacial water states on advanced biomedical material design. Adv Drug Deliv Rev. 2022;186:114310.
Nishimura S-n, Tanaka M. The Intermediate Water Concept for Pioneering Polymeric Biomaterials: A Review and Update. Bull Chem Soc Jpn. 2023;96:1052–70.
Kobayashi S, Okazaki Y, Tanaka M. Impact of side chain carbonyl group position on polymer hydration, dynamics, and antithrombotic activity: A systematic study of structure-property relationships. Macromolecules. 2025;58:8821–32.
Cho IS, Shiomoto S, Yukawa N, Tanaka Y, Huh KM, Tanaka M. The role of intermediate water in enhancing blood and cellular compatibility of chitosan-based biomaterials. Langmuir. 2025;41:8301–11.
Hale GM, Querry MR. Optical constants of water in the 200-nm to 200-μ m wavelength region. Appl Opt. 1973;12:555–63.
Tajiri T, Morita S, Ozaki Y. Time-resolved conformational analysis of poly(ethylene oxide) during the hydrogelling process. Polymer. 2011;52:5560–6.
Ohno K, Okimura M, Akai N, Katsumoto Y. The effect of cooperative hydrogen bonding on the oh stretching-band shift for water clusters studied by matrix-isolation infrared spectroscopy and density functional theory. Phys Chem Chem Phys. 2005;7:3005–14.
Morita S, Kitagawa K, Ozaki Y. Hydrogen-bond structures in poly(2-hydroxyethyl methacrylate): Infrared spectroscopy and quantum chemical calculations with model compounds. Vibr Spectrosc. 2009;51:28–33.
Morita S. Hydrogen-bonds structure in poly(2-hydroxyethyl methacrylate) studied by temperature-dependent infrared spectroscopy. Front Chem. 2014;2:1–5.
Yarwood J, Sammon C, Mura C, Pereira M. Vibrational spectroscopic studies of the diffusion and perturbation of water in polymeric membranes. J Mol liq. 1999;80:93–115.
Ide M, Mori T, Ichikawa K, Kitano H, Tanaka M, Mochizuki A, et al. Structure of water sorbed into poly (MEA-co-HEMA) films as examined by atr-ir spectroscopy. Langmuir. 2003;19:429–35.
Tajiri T, Morita S, Ozaki Y. Hydration mechanism on a poly(methacrylic acid) film studied by in situ attenuated total reflection infrared spectroscopy. Polymer. 2009;50:5765–70.
Morita S, Kitagawa K. Temperature-dependent structure changes in nafion ionomer studied by pcmw2d ir correlation spectroscopy. J Mol Struct. 2010;974:56–9.
Morita S, Tanaka M, Ozaki Y. Time-resolved in situ atr-ir observations of the process of sorption of water into a poly(2-methoxyethyl acrylate) film. Langmuir. 2007;23:3750–61.
Tanaka M, Hayashi T, Morita S. The roles of water molecules at the biointerface of medical polymers. Polym J. 2013;45:701–10.
Tanaka M, Morita S, Hayashi T. Role of interfacial water in determining the interactions of proteins and cells with hydrated materials. Colloids Surf B Biointerfaces. 2021;198:111449.
Tanaka M, Motomura T, Ishii N, Shimura K, Onishi M, Mochizuki A, et al. Cold crystallization of water in hydrated poly(2-methoxyethyl acrylate) (pmea). Polym Inter. 2000;49:1709–13.
Tanabe A, Morita S, Tanaka M, Ozaki Y. Multivariate curve resolution analysis on the multi-component water sorption process into a poly(2-methoxyethyl acrylate) film. Appl Spectrosc. 2008;62:46–50.
Morita S, Tanaka M, Noda I, Ozaki Y. Phase angle description of perturbation correlation analysis and its application to time-resolved infrared spectra. Appl Spectrosc. 2007;61:867–72.
Sekine T, Asatyas S, Sato C, Morita S, Tanaka M, Hayashi T. Surface force and vibrational spectroscopic analyses of interfacial water molecules in the vicinity of methoxy-tri (ethylene glycol)-terminated monolayers: Mechanisms underlying the effect of lateral packing density on bioinertness. J Biomater Sci Polym Ed. 2017;28:1231–43.
Shikata K, Kikutsuji T, Yasoshima N, Kim K, Matubayasi N Revealing the hidden dynamics of confined water in acrylate polymers: Insights from hydrogen-bond lifetime analysis. J. Chem. Phys. 2023;158:174901.
Morita S, Tanaka M, Kitagawa K, Ozaki Y. Hydration structure of poly(2-methoxyethyl acrylate): Comparison with a 2-methoxyethyl acetate model monomer. J Biomater Sci Polym Ed. 2010;21:1925–35.
Li GF, Ye S, Morita S, Nishida T, Osawa M. Hydrogen bonding on the surface of poly(2-methoxyethyl acrylate). J Am Chem Soc. 2004;126:12198–9.
Murakami D, Nishimura S-n, Tanaka Y, Tanaka M. Observing the repulsion layers on blood-compatible polymer-grafted interfaces by frequency modulation atomic force microscopy. Biomater Adv. 2022;133:112596.
Chang R, Asatyas S, Lkhamsuren G, Hirohara M, Mondarte EAQ, Suthiwanich K, et al. Water near bioinert self-assembled monolayers. Polym J. 2018;50:563–71.
Hayashi T. Prof. George whitesides’ contributions to self-assembled monolayers (sams): Advancing biointerface science and beyond. Chemistry-Switzerland. 2025;7:9–24.
Hayashi T, Hara M. Nonfouling self-assembled monolayers: Mechanisms underlying protein and cell resistance. Cur Phy Chem. 2011;1:90–8.
Hayashi T, Latag GV. Self-assembled monolayers as platforms for nanobiotechnology and biointerface research: Fabrication, analysis, mechanisms, and design. ACS Appl Nano Mater. 2025;8:8570–87.
Maeda S, Chikami S, Song S, Balois-Oguchi MV, Katase A, Latag GV, et al. Gap-controlled infrared absorption spectroscopy: A unique interface-sensitive spectroscopy based on the combination of linear spectroscopy and multivariate curve resolution. Anal Chem. 2025;97:20156–63.
Sekine T, Asatyas S, Sato C, Morita S, Tanaka M, Hayashi T. Surface force and vibrational spectroscopic analyses of interfacial water molecules in the vicinity of methoxy-tri(ethylene glycol)-terminated monolayers: Mechanisms underlying the effect of lateral packing density on bioinertness. J Biomater Sci Polym Ed. 2017;28:1231–43.
Sekine T, Tanaka Y, Sato C, Tanaka M, Hayashi T. Evaluation of factors to determine platelet compatibility by using self-assembled monolayers with a chemical gradient. Langmuir. 2015;31:7100–5.
Araki Y, Sekine T, Chang R, Hayashi T, Onishi H. Molecular-scale structures of the surface and hydration shell of bioinert mixed-charged self-assembled monolayers investigated by frequency modulation atomic force microscopy. RSC Adv. 2018;8:24660–4.
Hu G, Moon J, Hayashi T. Protein classes predicted by molecular surface chemical features: Machine learning-assisted classification of cytosol and secreted proteins. J Phys Chem B. 2024;128:8423–36.
Moon J, Hu G, Hayashi T. Application of machine learning in the quantitative analysis of the surface characteristics of highly abundant cytoplasmic proteins: Toward ai-based biomimetics. Biomimetics. 2024;9:162.
White AD, Nowinski AK, Huang WJ, Keefe AJ, Sun F, Jiang SY. Decoding nonspecific interactions from nature. Chem Sci. 2012;3:3488–94.
Cui Z, Wang Y, Zhang L, Qi H. Zwitterionic peptides: From mechanism, design strategies to applications. ACS Appl Mater Interfaces. 2024;16:56497–518.
Kanayama N, Sekine T, Ozasa K, Kishi S, Nyu T, Hayashi T, et al. Terminal-specific interaction between double-stranded DNA layers: Colloidal dispersion behavior and surface force. Langmuir. 2016;32:13296–304.
Sekine T, Kanayama N, Ozasa K, Nyu T, Hayashi T, Maeda M. Stochastic binding process of blunt-end stacking of DNA molecules observed by atomic force microscopy. Langmuir. 2018;34:15078–83.
Ang A, Maeda S, Chikami S, Hayashi T. Analysing the correlation between the water’s OH stretching band and its hydrogen bonding configurations by machine learning. Phys Chem Chem Phys. 2025;27:21083–97.
Hatakeyama T, Tanaka M, Hatakeyama H. Studies on bound water restrained by poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC): Comparison of the polysaccharides-water systems. Acta Biomater. 2010;6:2077–82.
Hatakeyama T, Tanaka M, Hatakeyama H. Thermal properties of freezing bound water restrained by polysaccharides. J Biomater Sci Polym Ed. 2010;21:1865–75.
Kumar A, Sood A, Agrawal G, Thakur S, Thakur VK, Tanaka M, et al. Polysaccharides, proteins, and synthetic polymers based multimodal hydrogels for various biomedical applications: A review. Int J Biol Macromol. 2023;247:125606.
Suzuki T, Konishi H, Suzuki A, Katsumata T, Fukuda Y, Miyamoto K, et al. Role of intermediate water in reducing postsurgical intrapericardial adhesion. Surg Today. 2025;55:847–56.
Tsujimoto H, Uehara H, Yoshida M, Nishio K, Furuta T, Inui T, et al. Different hydration states and passive tumor targeting ability of polyethylene glycol-modified dendrimers with high and low PEG density. Mater Sci Eng C. 2021;126:112159.
Fujiura K, Naito M, Tanaka Y, Tanaka M, Nakanishi Y, Ejima H, et al. Development of stealth nanoparticles coated with poly(2-methoxyethyl vinyl ether) as an alternative to poly(ethylene glycol). J Appl Polym Sci. 2024;141:e55044.
Toyokawa Y, Kobayashi S, Tsuchiya H, Shibuya T, Aoki M, Sumiya J, et al. A fully covered self-expandable metallic stent coated with poly(2-methoxyethyl acrylate) and its derivative: In vitro evaluation of early-stage biliary sludge formation inhibition. Mater Sci Eng C. 2021;120:111386.
Ishizawa T, Makino N, Kakizaki Y, Matsuda A, Toyokawa Y, Ooyama S, et al. Biosafety of a novel covered self-expandable metal stent coated with poly(2-methoxyethyl acrylate) in vivo. PLoS ONE. 2021;16:e0257828.
Nomura M, Yokoyama Y, Yoshimura D, Minagawa Y, Yamamoto A, Tanaka Y, et al. Simple detection and culture of circulating tumor cells from colorectal cancer patients using poly(2-methoxyethyl acrylate)-coated plates. Int J Mol Sci. 2023;24:3949.
Kobayashi S, Sugasaki A, Yamamoto Y, Shigenoi Y, Udaka A, Yamamoto A, et al. Enrichment of cancer cells based on antibody-free selective cell adhesion. ACS Biomater Sci Eng. 2022;8:4547–56.
Nishimura S-n, Nishida K, Shiomoto S, Tanaka M. Surfactant-free suspension polymerization of hydrophilic monomers with an oil-in-water system for the preparation of microparticles toward the selective isolation of tumor cells. Mater Adv. 2022;3:5043–54.
Nishida K, Nishimura S-n, Tanaka M. Selective accumulation to tumor cells with coacervate droplets formed from a water-insoluble acrylate polymer. Biomacromolecules. 2022;23:1569–80.
Lee W, Kobayashi S, Nagase M, Jimbo Y, Saito I, Inoue Y, et al. Nonthrombogenic, stretchable, active multielectrode array for electroanatomical mapping. Sci Adv. 2018;4:eaau2426.
Lee W, Jeong SH, Lim YW, Lee H, Kang J, Lee H, et al. Conformable microneedle pH sensors via the integration of two different siloxane polymers for mapping peripheral artery disease. Sci Adv. 2021;7:eabi6290.
Huang JJ, Lin CH, Tanaka Y, Yamamoto A, Luo SC, Tanaka M Manipulation of surface hydration states by tuning the oligo(ethylene glycol) moieties on PEDOT to achieve platelet-resistant bioelectrode applications. Adv Mater Interfaces. 2022;22:2200707.
Araki T, Yoshida F, Uemura T, Noda Y, Yoshimoto S, Kaiju T, et al. Long-term implantable, flexible, and transparent neural interface based on Ag/Au core–shell nanowires. Adv Healthcare Mater. 2019;8:1900130.
Nishida K, Ikura R, Yamaoka K, Urakawa O, Konishi T, Inoue T, et al. Relation between the water content and mechanical properties of hydrogels with movable cross-links. Macromolecules. 2024;57:7745–54.
Park J, Ueda T, Kawai Y, Araki K, Kido M, Kure B, et al. Simultaneous control of the mechanical properties and adhesion of human umbilical vein endothelial cells to suppress platelet adhesion on a supramolecular substrate. RSC Adv. 2022;12:27912–7.
Osaki M, Yonei S, Ueda C, Ikura R, Park J, Yamaguchi H, et al. Mechanical properties with respect to water content of host-guest hydrogels. Macromolecules. 2021;54:8067–76.
Okada M, Xie SC, Kobayashi Y, Yanagimoto H, Tsugawa D, Tanaka M, et al. Water-mediated on-demand detachable solid-state adhesive of porous hydroxyapatite for internal organ retractions. Adv Healthcare Mater. 2024;13:2304616.
Okada M, Hara E, Kobayashi D, Kai S, Ogura K, Tanaka M, et al. Intermediate water on calcium phosphate minerals: Its origin and role in crystal growth. ACS Appl Bio Mater. 2019;2:981–6.
Mabrouk M, Beherei HH, Tanaka Y, Tanaka M. Sol-gel silicate glass doped with silver for bone regeneration: Antibacterial activity, intermediate water, and cell death mode. Biomater Adv. 2022;138:212965.
Mabrouk M, Beherei HH, Shiomoto S, Tanaka Y, Osama L, Tanaka M. Effect of titanium-doped bioactive glass on poly(2-hydroxyethyl methacrylate) hydrogel composites: Bioactivity, intermediate water, cell proliferation, and adhesion force. Ceram Int. 2023;49:13469–81.
Mabrouk M, Beherei HH, Tanaka Y, Tanaka M. Investigating the intermediate water feature of hydrated titanium containing bioactive glass. Int J Mol Sci. 2021;22:8038.
Nishimura S-n, Nishida K, Ueda T, Shiomoto S, Tanaka M. Biocompatible poly(N-(ω-acryloyloxy-n-alkyl)-2-pyrrolidone)s with widely-tunable lower critical solution temperatures (LCSTs): a promising alternative to poly(N-isopropylacrylamide). Polym Chem. 2022;13:2519–30.
Koguchi R, Jankova K, Tanaka M. Fluorine-containing bio-inert polymers: Roles of intermediate water. Acta Biomater. 2022;138:34–56.
Sonoda T, Kobayashi S, Tanaka M. Periodically functionalized linear polyethylene with tertiary amino groups via regioselective ring-opening metathesis polymerization. Macromolecules. 2021;54:2862–72.
Liu S, Kobayashi S, Sonoda T, Tanaka M. Poly(tertiary amide acrylate) copolymers inspired by poly(2-oxazoline)s: Their blood compatibility and hydration states. Biomacromolecules. 2021;22:2718–28.
Liu S, Kobayashi S, Nishimura S-n, Ueda T, Tanaka M. Effect of pendant groups on the blood compatibility and hydration states of poly(2-oxazoline)s. J Polym Sci. 2021;59:2559–70.
Anjum R, Nishimura S, Kobayashi S, Nishida K, Anada T, Tanaka M. Protein stabilization effect of zwitterionic osmolyte-bearing polymer. Chem Lett. 2021;50:1699–702.
Sonoda T, Kobayashi S, Herai K, Tanaka M. Side-chain spacing control of derivatives of poly(2-methoxyethyl acrylate): Impact on hydration states and antithrombogenicity. Macromolecules. 2020;53:8570–80.
Koguchi R, Jankova K, Hayasaka Y, Kobayashi D, Amino Y, Miyajima T, et al. Understanding the effect of hydration on the bio-inert properties of 2-hydroxyethyl methacrylate copolymers with small amounts of amino- or/and fluorine-containing monomers. ACS Biomater Sci Eng. 2020;6:2855–66.
Koguchi R, Jankova K, Tanabe N, Amino Y, Hayasaka Y, Kobayashi D, et al. Controlling the hydration structure with a small amount of fluorine to produce blood compatible fluorinated poly(2-methoxyethyl acrylate). Biomacromolecules. 2019;20:2265–75.
Koguchi R, Jankova K, Tanaka Y, Yamamoto A, Murakami D, Yang Q, et al. Altering the Bio-inert Properties of Surfaces by Fluorinated Copolymers of mPEGMA. Biomater Adv. 2023;153:213573.
Yoshikawa C, Hattori S, Huang C-F, Kobayashi H, Tanaka M. In vitro and in vivo blood compatibility of concentrated polymer brushes. J Mater Chem B. 2021;9:5794–804.
Jankova K, Javakhishvili I, Kobayashi S, Koguchi R, Murakami D, Sonoda T, et al. Hydration states and blood compatibility of hydrogen-bonded supramolecular poly(2-methoxyethyl acrylate). ACS Appl Bio Mater. 2019;2:4154–61.
Sato K, Kobayashi S, Sekishita A, Wakui M, Tanaka M. Synthesis and thrombogenicity evaluation of poly(3-methoxypropionic acid vinyl ester): A candidate for blood-compatible polymers. Biomacromolecules. 2017;18:1609–16.
Kobayashi S, Wakui M, Iwata Y, Tanaka M. Poly(ω-methoxyalkyl acrylate)s: Nonthrombogenic polymer family with tunable protein adsorption. Biomacromolecules. 2017;18:4214–23.
Kobayashi S, Fukuda K, Kataoka M, Tanaka M. Regioselective ring-opening metathesis polymerization of 3-substituted cyclooctenes with ether side chains. Macromolecules. 2016;49:2493–501.
Sato K, Kobayashi S, Kusakari M, Watahiki S, Oikawa M, Hoshiba T, et al. The relationship between water structure and blood compatibility in poly(2-methoxyethyl acrylate) (PMEA) analogues. Macromol Biosci. 2015;15:1296–303.
Fukushima K, Inoue Y, Haga Y, Ota T, Honda K, Sato C, et al. Monoether-tagged biodegradable polycarbonate preventing platelet adhesion and demonstrating vascular cell adhesion: A promising material for resorbable vascular grafts and stents. Biomacromolecules. 2017;18:3834–43.
Nishimura S-n, Ueda T, Murakami D, Tanaka M. Chain-end effect for intermediate water formation of poly(2-methoxyethyl acrylate). Org Mater. 2021;3:214–20.
Nishimura S-n, Ueda T, Kobayashi S, Tanaka M. Silsesquioxane/poly(2-methoxyethyl acrylate) hybrid with both antithrombotic and endothelial cell adhesive properties. ACS Appl Polym Mater. 2020;2:4790–801.
Fukushima K, Hakozaki S, Lang R, Haga Y, Nakai S, Narumi A, et al. Hydrolyzable and biocompatible aliphatic polycarbonates with ether functionalized side chains attached via amide linker. Polym J. 2024;56:431–42.
Hayakawa N, Nishiura M, Anada T, Kobayashi S, Sawada T, Serizawa T, et al. Suspension culture system for isolating cancer spheroids using enzymatically synthesized cellulose oligomers. ACS Appl Bio Mater. 2024;7:306–14.
Kobayashi S, Tanaka M. Design of biomaterials through direct ring-opening metathesis polymerisation of functionalised cyclic alkenes. Mol Syst Des Eng. 2023;8:960–91.
Wen P, Ke W, Dirisala A, Toh K, Tanaka M, Li J. Stealth and pseudo-stealth nanocarriers. Adv Drug Deliv Rev. 2023;198:114895.
Higuchi Y, Saleh MA, Anada T, Tanaka M, Hishida M. Rotational dynamics of water near osmolytes by molecular dynamics simulations. J Phys Chem B. 2024;128:5008–17.
Kawai Y, Park J, Motokawa R, Ikura R, Murayama S, Yamaoka K, et al. Effects of the hydration states of water molecules on the mechanical properties of dual movable crosslinked polymeric gels. ACS Appl Polym Mater. 2025;7:7767–76.
Anada T, Kawahara M, Shimada T, Kuroda R, Okamura H, Setoyama D, et al. A nucleic acid prodrug that activates mitochondrial respiration, promotes stress resilience, and prolongs lifespan. J Am Chem Soc. 2025;147:22161–75.
Kawahara M, Miyazaki K, Anada T, Kobayashi S, Tanaka M Engineering three-dimensional cellular organization by regulating bound water-mediated cell–substrate interactions for disease modeling. ACS Omega. 2025;10:54951–66.
Li J, Toh K, Wen P, Liu X, Dirisala A, Guo H, et al. Steric stabilization-independent stealth cloak enables nanoreactors-mediated starvation therapy against refractory Cancer. Nat Biomed Eng. https://doi.org/10.1038/s41551-025-01534-1 2025.
