Lesion-targeted, severity-responsive nanoparticle delivery for RNA therapy in osteoarthritis

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Lesion-targeted, severity-responsive nanoparticle delivery for RNA therapy in osteoarthritis
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Nanomedicine delivery

Nature Nanotechnology (2026)Cite this article

Subjects

Matrix-INverse Targeting (MINT) nanoparticles harness cartilage changes to deliver RNA therapies, reducing degeneration and pain in osteoarthritis.

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Fig. 1: Mechanism of lesion-targeted, severity-responsive RNA delivery by MINT nanoparticles.

References

  1. Leifer, V. P., Katz, J. N. & Losina, E. Osteoarthr. Cartil. 30, 10–16 (2022).

    Article  CAS  Google Scholar 

  2. Hodgkinson, T., Kelly, D. C., Curtin, C. M. & O’Brien, F. J. Nat. Rev. Rheumatol. 18, 67–84 (2022).

    Article  PubMed  Google Scholar 

  3. Schambach, A. et al. Lancet 403, 568–582 (2024).

    Article  PubMed  CAS  Google Scholar 

  4. Dewani, M. Nat Nanotechnol. https://doi.org/10.1038/s41565-025-02101-0 (2025).

    Article  Google Scholar 

  5. Thi, T. T. H. et al. Vaccines 9, 359 (2021).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  6. Alsaab, H. O. et al. Pharmaceutics 14, 2728 (2022).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. Geng, G. et al. EBioMedicine 118, 105834 (2025).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. Joyce, M. et al. Eur. Cell. Mater. 47, 91–108 (2024).

    Article  CAS  Google Scholar 

  9. Zhong, R. et al. Nat. Mater. 22, 818–831 (2023).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  10. Intini, C. et al. Adv. Therap. 6, 2200329 (2023).

    Article  CAS  Google Scholar 

  11. An, S. et al. Mater. Today Bio. 30, 101382 (2025).

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy

    Claudio Intini

  2. Tissue Engineering Research Group, Department of Anatomy & Regenerative Medicine, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland

    Claudio Intini & Fergal J. O’Brien

  3. Advanced Materials and Bioengineering Research (AMBER) Centre, RCSI & TCD, Dublin, Ireland

    Fergal J. O’Brien

Authors

  1. Claudio Intini
  2. Fergal J. O’Brien

Corresponding author

Correspondence to Fergal J. O’Brien.

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Competing interests

The authors declare no competing interests.

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Intini, C., O’Brien, F.J. Lesion-targeted, severity-responsive nanoparticle delivery for RNA therapy in osteoarthritis. Nat. Nanotechnol. (2026). https://doi.org/10.1038/s41565-025-02067-z

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