Nano-functionalized probiotic treats atherosclerosis via inhibiting intestinal microbiota-TMA-TMAO axis

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Author notes

1. These authors contributed equally: Zhezhe Chen, Qiongjun Zhu.

Authors and Affiliations

1. Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China

   Zhezhe Chen, Qiongjun Zhu, Yanan Wang, Zhebin Chen, Yao Wang, Guosheng Fu, Boxuan Ma & Wenbin Zhang

2. Zhejiang Key Laboratory of Cardiovascular Intervention and Precision Medicine, Hangzhou, China

   Zhezhe Chen, Qiongjun Zhu, Yanan Wang, Zhebin Chen, Yao Wang, Guosheng Fu, Boxuan Ma & Wenbin Zhang

3. Engineering Research Center for Cardiovascular Innovative Devices of Zhejiang Province, Hangzhou, China

   Zhezhe Chen, Qiongjun Zhu, Yanan Wang, Zhebin Chen, Yao Wang, Guosheng Fu, Boxuan Ma & Wenbin Zhang

4. National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China

   Hong Xu

5. Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

   Yiqing Hu

6. School of Electronic Engineering and Computer Science, Queen Mary University of London, London, UK

   Xingru Huang

Contributions

All authors have read and approved the manuscript. Z.C. (Zhezhe Chen) and B.M. conceived and designed the study. Z.C. (Zhezhe Chen), Q.Z., H.X. and B.M. performed the experiments. H.X. and B.M. synthesized and prepared the nanoparticles. Z.C. (Zhezhe Chen), Y.H. and X.H. analyzed the microbiome and metabolomics data. Y.W. (Yanan Wang), Z.C. (Zhebin Chen), and Y.W. (Yao Wang) assisted in the experiments and drew the figures. Z.C. (Zhezhe Chen) and B.M. wrote the manuscript. G.F., B.M. and W.Z. revised the manuscript and supervised this study.

Corresponding authors

Correspondence to Guosheng Fu, Boxuan Ma or Wenbin Zhang.

Competing interests

The authors declare no competing interests.

Peer review information

Nature Communications thanks Jianxiang Zhang, Ahmad Ud Din and Ricardo Fernandes for their contribution to the peer review of this work. [A peer review file is available.]

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