Nanoformulation of pomegranate peel extract enhances anti-psoriatic efficacy in a rat model

nanoformulation-of-pomegranate-peel-extract-enhances-anti-psoriatic-efficacy-in-a-rat-model
Nanoformulation of pomegranate peel extract enhances anti-psoriatic efficacy in a rat model

References

  1. Raharja, A., Mahil, S. K. & Barker, J. N. Psoriasis: a brief overview. Clin. Med. 21, 170–173 (2021).

    Google Scholar 

  2. Hay, S. I. et al. Global, regional, and National disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the global burden of disease study 2016. Lancet 390, 1260–1344 (2017).

    Google Scholar 

  3. Ganzetti, G. et al. Salivary interleukin-1beta: oral inflammatory biomarker in patients with psoriasis. J. Int. Med. Res. 44, 10–14 (2016).

    Google Scholar 

  4. Deng, Y., Chang, C. & Lu, Q. The inflammatory response in psoriasis: a comprehensive review. Clin. Rev. Allergy Immunol. 50, 377–389 (2016).

    Google Scholar 

  5. Kagami, S., Rizzo, H. L., Lee, J. J., Koguchi, Y. & Blauvelt, A. Circulating Th17, Th22, and Th1 cells are increased in psoriasis. J. Invest. Dermatol. 130, 1373–1383 (2010).

    Google Scholar 

  6. Verghese, B., Bhatnagar, S., Tanwar, R. & Bhattacharjee, J. Serum cytokine profile in psoriasis-a case-control study in a tertiary care hospital from Northern India. Indian J. Clin. Biochem. 26, 373–377 (2011).

    Google Scholar 

  7. Cardoso, P. R. et al. Clinical and cytokine profile evaluation in Northeast Brazilian psoriasis plaque-type patients. Eur. Cytokine Netw. 27, 1–5 (2016).

    Google Scholar 

  8. Liu, R., Yang, Y., Yan, X. & Zhang, K. Abnormalities in cytokine secretion from mesenchymal stem cells in psoriatic skin lesions. Eur. J. Dermatol. 23, 600–607 (2013).

    Google Scholar 

  9. Guenova, E. et al. IL-4 abrogates TH17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells. Proc. Natl. Acad. Sci. U. S. A. 112, 2163–2168 (2015).

  10. Onderdijk, A. J. et al. IL-4 downregulates IL-1beta and IL-6 and induces GATA3 in psoriatic epidermal cells: route of action of a Th2 cytokine. J. Immunol. 195, 1744–1752 (2015).

    Google Scholar 

  11. Samarasekera, E., Sawyer, L., Parnham, J. & Smith, C. H. Assessment and management of psoriasis: summary of NICE guidance. BMJ 345 (2012).

  12. Ling, T. C. et al. British association of dermatologists and British photodermatology group guidelines for the safe and effective use of psoralen-ultraviolet A therapy 2015. Br. J. Dermatol. 174, 24–55 (2016).

    Google Scholar 

  13. Mahil, S. K. et al. BADBIR study group and the PSORT consortium: psoriasis treat to target: defining outcomes in psoriasis using data from a real-world, population-based cohort study (the British association of dermatologists biologics and immunomodulators Register, BADBIR). Br. J. Dermatol. 182, 1158–1166 (2020).

    Google Scholar 

  14. Cheng, J. et al. Bioactive compounds and health benefits of pomegranate: an updated narrative review. Food Biosci. 53, 102629 (2023).

    Google Scholar 

  15. Feldman, S. R. & Krueger, G. Psoriasis assessment tools in clinical trials. Ann. Rheum. Dis. 64, ii65–ii68 (2005).

    Google Scholar 

  16. Elkhawaga, O. Y., Ellety, M. M., Mofty, S. O., Ghanem, M. S. & Mohamed, A. O. Review of natural compounds for potential psoriasis treatment. Inflammopharmacology 31, 1183–1198 (2023).

    Google Scholar 

  17. Singh, K. K. & Tripathy, S. Natural treatment alternative for psoriasis: A review on herbal resources. J. Appl. Pharm. Sci. 4, 114–121 (2014).

    Google Scholar 

  18. Brown, A. C. et al. Medical nutrition therapy as a potential complementary treatment for psoriasis-five case reports. Altern. Med. Rev. 9, 297–307 (2004).

    Google Scholar 

  19. Mo, Y. et al. Pomegranate Peel as a source of bioactive compounds: A mini review on their physiological functions. Front. Nutr. 9, 887113 (2022).

    Google Scholar 

  20. Wu, Y., Zhu, C. P., Zhang, Y., Li, Y. & Sun, J. R. Immunomodulatory and antioxidant effects of pomegranate Peel polysaccharides on immunosuppressed mice. Int. J. Biol. Macromol. 137, 504–511 (2019).

    Google Scholar 

  21. Zhai, X. et al. Chemical characteristics, antioxidant capacities and hepatoprotection of polysaccharides from pomegranate Peel. Carbohydr. Polym. 202, 461–469 (2018a).

    Google Scholar 

  22. Zhai, X. et al. Optimization for pectinase-assisted extraction of polysaccharides from pomegranate Peel with chemical composition and antioxidant activity. Int. J. Biol. Macromol. 202, 461–469 (2018).

    Google Scholar 

  23. Panichayupakaranant, P., Itsuriya, A. & Sirikatitham, A. Preparation method and stability of ellagic acid-rich pomegranate fruit Peel extract. Pharm. Biol. 48, 201–205 (2010).

    Google Scholar 

  24. Ismail, T., Sestili, P. & Akhtar, S. Pomegranate Peel and fruit extracts: a review of potential anti-inflammatory and anti-infective effects. J. Ethnopharmacol. 143, 397–405 (2012).

    Google Scholar 

  25. Tamborlin, L. et al. Characterization of pomegranate Peel extracts obtained using different solvents and their effects on cell cycle and apoptosis in leukemia cells. Food Sci. Nutr. 8, 5483–5496 (2020).

    Google Scholar 

  26. Kaderides, K. & Goula, A. M. Encapsulation of pomegranate Peel extract with a new carrier material from orange juice by-products. J. Food Eng. 253, 1–13 (2019).

    Google Scholar 

  27. Mohammadi, M., Boghrati, Z., Emami, S. A. & Akaberi, M. Pomegranate: A review of the heavenly healer’s past, present, and future. Iran. J. Basic. Med. Sci. 26, 1245 (2023).

    Google Scholar 

  28. Siddiqui, S. A., Singh, S. & Nayik, G. A. Bioactive compounds from pomegranate peels-Biological properties, structure-function relationships, health benefits, and food applications-A comprehensive review. J. Funct. Foods. 116, 106132 (2024).

    Google Scholar 

  29. Enaru, B., Drețcanu, G., Pop, T. D., Stǎnilǎ, A. & Diaconeasa, Z. Anthocyanins: factors affecting their stability and degradation. Antioxidants 10, 1967 (2021).

    Google Scholar 

  30. Elbouzidi, A. et al. Biochemical insights into specialized plant metabolites: advancing cosmeceutical applications for skin benefits. J. Agric. Food Res. 19, 101651 (2025).

    Google Scholar 

  31. Morsy, M. K., Mekawi, E. & Elsabagh, R. Impact of pomegranate Peel nanoparticles on quality attributes of meatballs during refrigerated storage. LWT Food Sci. Technol. 89, 489–495 (2017).

    Google Scholar 

  32. Salem, Y. et al. Grape seed phenolic extracts encapsulation in polymeric nanoparticles: characterization and in vitro evaluation against skin melanoma. J. Drug Deliv Sci. Technol. 100, 106094 (2024).

    Google Scholar 

  33. Association of Official Analytical Chemists. Official methods of analysis. J. AOAC Int. 83, 1–15 (2000).

    Google Scholar 

  34. Balamurugan, V., Fatima, M. A. S. & Velurajan, S. A guide to phytochemical analysis. IJARIIE 5, 236–245 (2019).

    Google Scholar 

  35. Sweidan, N., Rayyan, A., Mahmoud, W. & Ali, I. Phytochemical analysis, antioxidant, and antimicrobial activities of Jordanian pomegranate peels. PLoS One. 18, e0295129 (2023).

    Google Scholar 

  36. Li, Y. et al. Evaluation of antioxidant properties of pomegranate Peel extract in comparison with pomegranate pulp extract. Food Chem. 96, 254–260 (2006).

    Google Scholar 

  37. Djeridane, A. et al. Antioxidant activity of some Algerian medicinal plant extracts containing phenolic compounds. Food Chem. 97, 654–660 (2006).

    Google Scholar 

  38. Mostafa, H., Airouyuwa, J. O. & Maqsood, S. A novel strategy for producing nanoparticles from date seeds and enhancing their phenolic content and antioxidant properties using ultrasound-assisted extraction: A multivariate-based optimization study. Ultrason. Sonochem. 87, 106017 (2022).

    Google Scholar 

  39. Weng, J., Tong, H. H. Y. & Chow, S. F. In vitro release study of the polymeric drug nanoparticles: development and validation of a novel method. Pharmaceutics 12, 732 (2020).

    Google Scholar 

  40. Salim, A. et al. Antimicrobial and antibiofilm activities of pomegranate Peel phenolic compounds: varietal screening through a multivariate approach. J. Bioresour Bioprod. 8, 146–161 (2023).

    Google Scholar 

  41. Horváth, S. et al. Methodological refinement of Aldara-induced psoriasiform dermatitis model in mice. Sci. Rep. 9, 3685 (2019).

    Google Scholar 

  42. Afaq, F., Saleem, M., Krueger, C. G., Reed, J. D. & Mukhtar, H. Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice. Int. J. Cancer. 113, 423–433 (2005).

    Google Scholar 

  43. Lansky, E. P. & Newman, R. A. Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer. J. Ethnopharmacol. 109, 177–206 (2007).

    Google Scholar 

  44. Teniente, S. L. et al. Anticancer effect of pomegranate Peel polyphenols against cervical cancer. Antioxidants 12, 127 (2023).

    Google Scholar 

  45. Ferrentino, G., Asaduzzaman, M. & Scampicchio, M. M. Current technologies and new insights for the recovery of high valuable compounds from fruits by-products. Crit. Rev. Food Sci. Nutr. 58, 386–404 (2018).

    Google Scholar 

  46. Wu, S. & Tian, L. Diverse phytochemicals and bioactivities in the ancient fruit and modern functional food pomegranate (Punica granatum). Molecules 22, 1606 (2017).

    Google Scholar 

  47. Kahramanoglu, I. Trends in pomegranate sector: Production, postharvest handling and marketing. Int. J. Agric. Life Sci. 3, 239–246 (2019).

    Google Scholar 

  48. Mastrogiovanni, F. et al. Anti-inflammatory effects of pomegranate Peel extracts on in vitro human intestinal Caco-2 cells and ex vivo Porcine colonic tissue explants. Nutrients 11, 548 (2019).

    Google Scholar 

  49. Ko, K., Dadmohammadi, Y. & Abbaspourrad, A. Nutritional and bioactive components of pomegranate waste used in food and cosmetic applications: a review. Foods 10, 657 (2021).

    Google Scholar 

  50. Mudshinge, S. R., Deore, A. B., Patil, S. & Bhalgat, C. M. Nanoparticles: emerging carriers for drug delivery. Saudi Pharm. J. 19, 129–141 (2011).

    Google Scholar 

  51. Naji-Tabasi, S., Razavi, S. M. A. & Mehditabar, H. Fabrication of Basil seed gum nanoparticles as a novel oral delivery system of glutathione. Carbohydr. Polym. 157, 1703–1713 (2017).

    Google Scholar 

  52. Xiong, K. et al. Construction of food-grade pH-sensitive nanoparticles for delivering functional food ingredients. Trends Food Sci. Technol. 96, 102–113 (2020).

    Google Scholar 

  53. Zayed, A., Badawy, M. T. & Farag, M. A. Valorization and extraction optimization of citrus seeds for food and functional food applications. Food Chem. 355 (2021).

  54. Guo, Y. et al. Petroselinic acid from apiaceae family plants ameliorates autoimmune disorders through suppressing cytosolic-nucleic-acid-mediated type i interferon signaling. Biomolecules 15, 329 (2025).

    Google Scholar 

  55. Gunasekaran, T., Haile, T., Nigusse, T. & Dhanaraju, M. D. Nanotechnology: an effective tool for enhancing bioavailability and bioactivity of phytomedicine. Asian Pac. J. Trop. Biomed. 4, S1–S7 (2014).

    Google Scholar 

  56. Barichello, J. M., Morishita, M., Takayama, K. & Nagai, T. Encapsulation of hydrophilic and lipophilic drugs in PLGA nanoparticles by the nanoprecipitation method. Drug Dev. Ind. Pharm. 25, 471–476 (1999).

    Google Scholar 

  57. van der Fits, L. et al. Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J. Immunol. 182, 5836–5845 (2009).

    Google Scholar 

  58. El Malki, K. et al. An alternative pathway of imiquimod-induced psoriasis-like skin inflammation in the absence of interleukin-17 receptor a signaling. J. Invest. Dermatol. 133, 441–451 (2013).

    Google Scholar 

  59. Nadeem, A. et al. Imiquimod-induced psoriasis-like skin inflammation is suppressed by BET bromodomain inhibitor in mice through RORC/IL-17A pathway modulation. Pharmacol. Res. 99, 248–257 (2015).

    Google Scholar 

  60. Yu, Y. Q., Yang, X., Wu, X. F. & Fan, Y. B. Enhancing permeation of drug molecules across the skin via delivery in nanocarriers: novel strategies for effective transdermal applications. Front. Bioeng. Biotechnol. 9, 646554 (2021).

    Google Scholar 

  61. Zheng, B. & McClements, D. J. Formulation of more efficacious Curcumin delivery systems using colloid science: enhanced solubility, stability, and bioavailability. Molecules 25, 279 (2020).

    Google Scholar 

  62. Yin, X. et al. Chemical stability of ascorbic acid integrated into commercial products: a review on bioactivity and delivery technology. Antioxidants 11, 153 (2022).

    Google Scholar 

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