Orchestrated growth factor release for muscle restoration

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Orchestrated growth factor release for muscle restoration
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Tissue engineering

Nature Materials (2025)Cite this article

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Implantable bioconstructs with sequential release of growth factors promote enhanced myofibre formation, angiogenesis and innervation in a mouse model of volumetric muscle loss.

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Fig. 1: A schematic illustration of bioconstructs performing staged GF release for the treatment of VML.

References

  1. Rovere, G. et al. Orthop. Rev. 14, 33943 (2022).

    Google Scholar 

  2. Grünherz, L. et al. Breast J. 26, 1980–1986 (2020).

    PubMed  Google Scholar 

  3. Quarta, M. et al. Nat. Commun. 8, 15613 (2017).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Lee, K., Silva, E. A. & Mooney, D. J. J. R. Soc. Interface. 8, 153–170 (2011).

    CAS  PubMed  Google Scholar 

  5. Wu, D. et al. Nat. Mater. https://doi.org/10.1038/s41563-025-02212-y (2025).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Zhang, F. & King, M. W. Adv. Healthc. Mater. 9, 1901358 (2020).

    CAS  Google Scholar 

  7. Borselli, C. et al. Proc. Natl Acad. Sci. USA 107, 3287–3292 (2010).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Cezar, C. A. & Mooney, D. J. Adv. Drug Deliv. Rev. 84, 188–197 (2015).

    CAS  PubMed  Google Scholar 

  9. Fischer, E. O. et al. Adv. Healthc. Mater. 14, 2404542 (2025).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Tsukerman, A. et al. Small Sci. 4, 2400228 (2024).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Levenberg, S. et al. Nat. Biotechnol. 23, 879–884 (2005).

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel

    Eliana O. Fischer, Anna Tsukerman & Shulamit Levenberg

  2. Interdisciplinary Program for Biotechnology, Technion-Israel Institute of Technology, Haifa, Israel

    Anna Tsukerman

Authors

  1. Eliana O. Fischer
  2. Anna Tsukerman
  3. Shulamit Levenberg

Corresponding author

Correspondence to Shulamit Levenberg.

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Competing interests

The authors declare no competing interests.

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Cite this article

Fischer, E.O., Tsukerman, A. & Levenberg, S. Orchestrated growth factor release for muscle restoration. Nat. Mater. (2025). https://doi.org/10.1038/s41563-025-02330-7

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  • DOI: https://doi.org/10.1038/s41563-025-02330-7