Organic solution advanced spray-dried microparticulate dry powder of doxycycline hyclate for lung delivery

ATR-FTIR:

Attenuated total reflectance-fourier-transform infrared spectroscopy

CRP:

C-reactive protein

DPI:

Dry powder inhaler

DSC:

Differential scanning calorimetry

ED:

Emitted dose

FDA:

Food & drug administration

GSD:

Geometric standard deviation

HSM:

Hot stage microscopy

IL-6:

Interleukin-6

KFT:

Karl fischer titration

MMAD:

Mass median aerodynamic diameter

MMP:

Matrix metalloproteinase

OSA:

Obstructive sleep apnea

RF:

Respirable fraction

SD:

Spray dried

SEM:

Scanning electron microscopy

TNF-α:

Tumor necrosis alpha

XRPD:

X- Ray powder diffraction

%FPF:

Fine particles emitted

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Author notes

1. Basanth Babu Eedara

   Present address: Transpire Bio Inc, 2945 W Corporate Lakes Blvd Suite A, Miami, FL, 33331, USA

Authors and Affiliations

1. The University of ArizonaR. Ken Coit College of PharmacySkaggs Pharmaceutical Sciences Center, Tucson, AZ, USA

   Hanan Alameddin, Wafaa Alabsi, Basanth Babu Eedara, Neftali Ortega Alarcon, Roberto Guzman & Heidi M. Mansour

2. Center for Translational Science, Florida International University, Port St. Lucie, FL, USA

   Basanth Babu Eedara & Heidi M. Mansour

3. Robert Stempel College of Public Health and Social Work, Departmentof EnvironmentalHealthSciences, Florida International University, Weston, FL, USA

   Basanth Babu Eedara & Heidi M. Mansour

4. The University of Arizona Health Sciences Center for Sleep Circadian and Neurosciences Research, Tucson, AZ, USA

   Richard L De Armond, Saif Mashaqi & Sairam Parthasarathy

5. College of Engineering, DepartmentsofChemicalandEnvironmentald-Engineering, The University of Arizona, Tucson, AZ, USA

   Roberto Guzman

6. College of Engineering, DepartmentsofBiomedicalEngineering, The University of Arizona, Tucson, AZ, USA

   Roberto Guzman

7. Department of Medicine, DivisionofTranslationalandRegenerative Medicine, The University of Arizona College of Medicine, Tucson, AZ, USA

   Heidi M. Mansour

8. Department of Cell and Molecular Medicine, Florida International University, HerbertWertheimCollegeofMedicine, Miami, FL, USA

   Heidi M. Mansour

Contributions

H.A: Writing – original draft, Methodology, Project administration, Investigation, Formal analysis, Data curation, Conceptualization. W.A., B.B.E., N.O. and R.D.A. **:** Writing – original draft, Methodology, Formal analysis, Data curation, Conceptualization. S.M., S.P., R.G., and H.M. **:** Writing – review & editing, Supervision, Resources, Project administration, Methodology, Investigation, Funding acquisition, Formal analysis, Conceptualization.

Corresponding author

Correspondence to Hanan Alameddin.

Competing interest

The authors declare no competing interests.

Conflicts of interest

S.P. also reports the following conflicts of interest that are not related to the content of this manuscript (Grants from Philips, Inc., Verily Lifesciences, Inc., Regeneron, Inc., US Biotest, Inc., and Sommetrics, Inc. that were awarded to the institution). S.P. has served as a consultant for Jazz Pharmaceuticals, Inc. within the past 2 years. He has a patent for a home-based breathing system (US20160213879A1) that has been licensed by SaiOx, Inc.

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