Reduce the risk of microbial activity and cytotoxicity by Adansonia digitata pulp extract grown under the semi arid conditions of Sudan

Posted on
reduce-the-risk-of-microbial-activity-and-cytotoxicity-by-adansonia-digitata-pulp-extract-grown-under-the-semi-arid-conditions-of-sudan
Reduce the risk of microbial activity and cytotoxicity by Adansonia digitata pulp extract grown under the semi arid conditions of Sudan

References

  1. Georgiev, V. G. & Weber, J. Kneschke antioxidant activity and phenolic content of African baobab (Adansonia digitata L.) pulp and seeds extracts Europ. Food Res. Technol. 243 (12), 2283–2293 (2017).

    Google Scholar 

  2. Abere, M., Yilma, Z., Tsegie, T., Eshete, A. & Alemu, A. Population structure and phenological attributes of Adansonia digitata L.(baobab) in Northwestern lowland area of Ethiopia. Heliyon 9 (12). https://doi.org/10.1016/j.heliyon.2023.e22571 (2023).

  3. Aljuhaimi et al. Z. Albakry Influence of coconut pulp on bioactive properties, fatty acids, phenolic compounds, nutrients and sensory evaluation of wheat flour bread. Int. J. Food Sci. Technol., 59(6), 4020–4029. (2024).

  4. Fakhri, S., Moradi, S. Z., Farzaei, M. H. & Bishayee, A. Modulation of dysregulated cancer metabolism by plant secondary metabolites: A mechanistic review. In: Semin Cancer Biol. Academic Press; c May. p. 80. (2022). https://doi.org/10.1016/j.semcancer.2020.02.007

  5. Iqbal, J., Abbasi, B. A. & Mahmood, T. Plant-derived anticancer agents: A green anticancer approach. Asian Pac. J. Trop. Biomed. 7 (12), 1129–1150. https://doi.org/10.1016/j.apjtb.2017.10.016 (2017).

    Google Scholar 

  6. Kamanula, M. Mineral and phytochemical composition of baobab (Adansonia digitata L.) root tubers from selected natural populations of Malawi. Malawi Med. J. 30, 250–255. https://doi.org/10.4314/mmj.v30i4.7 (2018).

    Google Scholar 

  7. Braca, A. et al. Phytochemical profile, antioxidant and antidiabetic activities of Adansonia digitata L. (baobab) from Mali, as a source of health-promoting compounds. Molecules 23, 3104. https://doi.org/10.3390/molecules23123104 (2018).

    Google Scholar 

  8. Adsina, J. A. & Zhu, J. A review of the geographical distribution, Indigenous benefits and conservation of baobab (Adansonia digitata L.) tree in sub-saharan Africa. Preprint 2022 https://doi.org/10.20944/preprints202205.0287.v1

  9. Ndjouenkeu, R., Fombang, E. N., Nkenmogne, I. E. K., Panyoo, E. A. & Yadang, G. Technological and nutraceutical development potentials of some traditional and underutilized plant foods of the savanna region of Cameroon. In Nutritional and Health Aspects of Food in Western Africa 31–65 (Elsevier, 2024).

    Google Scholar 

  10. Ahmed, A. E. M. et al. Potential of baobab (Adansonia digitata L.) dried fruit pulp in contributing to food and nutrient security in Sudan and Senegal. J. Agric. Food Res. 19, 101681 (2025).

    Google Scholar 

  11. Stadlmayr, B. et al. Nutritional composition of baobab (Adansonia digitata L.) fruit pulp sampled at different geographical locations in Kenya J. Food Compos. Anal.(2020).

  12. Thompson, P. T. & Boamah, V. E. Ba du In-vitro antioxidant,antimicrobial and phytochemical properties of extracts from the pulp and seeds of the African baobab fruit (Adansonia digitata L. Heliyon 10 (8). https://doi.org/10.1016/j.heliyon.2024.e29660 (2024). Article e29660.

  13. Saeed, H. A. M., Adam, Y. O., Donkor, E. & Mithöfer, D. Consumers’ behavior, attitudes, and beliefs regarding baobab (Adansonia digitata L.) fruit and pulp consumption in Sudan front. Sustain. Food Syst. 7, 1–13. https://doi.org/10.3389/fsufs.2023.1118714 (2023).

    Google Scholar 

  14. H.S.E.I.E.A. Alaziz et al. Phytochemical analysis, antioxidant, cytotoxicity and antibacterial activity of Adansonia digitata L. seeds ethanol extract. J. Pharmacogn. Phytochem. 8 (2019).

  15. Ajiboye, A. E., Sadiq, S. O. & Adedayo, M. R. Antimicrobial activity and phytochemical screening of Adansonia digitata stem bark extract on some clinical isolates. Ife J. Sci. 22 (2), 35–44 (2020).

    Google Scholar 

  16. Srivastava, A. K., Singh, A. & Singh, V. K. Comprehensive review of Adansonia digitata (Kalpvriksha): Ethnobotany, phytochemistry, and potential applications. Algeria J. Biosci. 05 (01), 13–023 (2024).

    Google Scholar 

  17. Carly, A. B. et al. Cervical cancer therapies: current challenges and future perspectives. Tumour Virus Res. 13, 200238 (2022).

    Google Scholar 

  18. Rivera-Martínez, A. R. et al. Fruit Extract of Sechiumchinantlense (& F. Chiang) Induces Apoptosis in the Human Cervical Cancer HeLa Cell Line. Nutrients. 15(3):667. (2023).

  19. Debelo, H. et al. Compositional analysis of phytochemicals and polysaccharides from Senegalese plant ingredients: Adansonia digitata (baobab), Moringa Oleifera (moringa) and hibsicus Sabdariffa (hibiscus). NFS J. 32 (2023).

  20. El Yahyaoui, O. et al. The antibacterial activity and biochemical composition of Adansonia digitata edible parts. Arab. Gulf J. Sci. Res. 41, 91–106 (2023). [Google Scholar] [CrossRef].

    Google Scholar 

  21. Bešlo, D. et al. Antioxidant activity, metabolism, and bioavailability of polyphenols in the diet of animals. Antioxidants 12, 1141 (2023). [Google Scholar] [CrossRef.

    Google Scholar 

  22. Chabite, I. T. et al. Morphological characterization, nutritional and biochemical properties of baobab (Adansonia digitata L.) fruit pulp from two districts of Mozambique. EC Nutr. 14 (2), 158–164 (2019).

    Google Scholar 

  23. Offiah, V. O. & Falade, K. O. Potentials of baobab in food systems. Appl. Food Res. 3 (1), 100299. https://doi.org/10.1016/j.afres.2023.100299 (2023).

    Google Scholar 

  24. Kouassi, K. N. et al. Amani nutritional and metabolic profiles of three traditional functional dishes based on maize flour and wild fruit pulp of Tomi (Tamarindus indica), baobab (Adansonia digitata) and néré (Parkia biglobosa) consumed in Côte d’ivoire. J. Food Biochem. https://doi.org/10.1155/jfbc/8812417 (2025).

    Google Scholar 

  25. Barakat, H. Nutritional and rheological characteristics of composite flour substituted with baobab (Adansonia digitata L.) pulp flour for cake manufacturing and organoleptic properties of their prepared cakes. Foods 10 (4), 716 (2021).

    Google Scholar 

  26. Musyoki, J. K. et al. Distribution and population status of Adansonia digitata L. (baobab) and its contribution to livelihood in Makueni County, Kenya. Trees Forests People. 8, 9p. 100270 (2022).

    Google Scholar 

  27. Wan, J. N. et al. The rise of baobab trees in Madagascar. Nat 629 (8014), 1091–1099 (2024).

    Google Scholar 

  28. Sakr, S. S. et al. Nutritional, physicochemical, microstructural, rheological, and organoleptical characteristics of ice cream incorporating Adansonia digitata pulp flour. Foods 12, 533. https://doi.org/10.3390/foods12030533 (2023).

    Google Scholar 

  29. Owolodun, B. & Merten, S. Food security from the forest: the case of the commodification of baobab fruit (Adansonia digitata L.) in Boundou Region, Senegal. Land 12 (7), 1423. https://doi.org/10.3390/land12071423 (2023).

    Google Scholar 

  30. Monteiro, S. et al. Development of a functional dark chocolate with baobab pulp. Foods 12 (8). https://doi.org/10.3390/foods12081711 (2023).

  31. Dossa, S. et al. Nutritional, physico-chemical, phytochemical, and rheological characteristics of composite flour substituted by baobab pulp flour (Adansonia digitata L.) for bread making. Foods 12 (14). https://doi.org/10.3390/foods12142697 (2023).

  32. Bougatef, H. et al. Polysaccharides from baobab (Adansonia digitata) fruit pulp: Structural features and biological properties South African Journal of Botany (2023).

  33. Magaldia, S. et al. Carolina Olaizolaa, Yudith ontiverosb: well diffusion for antifungal susceptibility testing. Int. J. Infect. Dis. 8, 39–45 (2004). S. Mata-Essayaga,*C. Hartung de Caprilesa, C. Pereza,M.T.

    Google Scholar 

  34. Espinel-Ingroff, A. et al. Muticenter evaluation of a new disk agar diffusion method for susceptibility testing of filamentous fungi with voriconazole, posaconazole, itraconazole, amphotericin B and Caspofungin. Clin. Microbiol. 45, 1811–1820 (2007).

    Google Scholar 

  35. Espinel-Ingroff, A. et al. Quality control guidelines for amphotericin B, itraconazole, posaconazole and voriconazole disk diffusion susceptibility tests with non-supplemented Mueller-Hinton agar (M51-A document) for nondermatophyte filamentous fungi. J. Clin. Microbiol. 49, 2568–2571 (2011).

    Google Scholar 

  36. National Committee for Clinical Laboratory Standards (NCCLS). Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically; Approved Standard (National Committee for Clinical Laboratory Standards, 2002).

  37. van de Loosdrecht, A. A. et al. J. Immunol. Methods : 174: 311–320. (1994).

    Google Scholar 

  38. Magashi, A. M. & Abdulmalik, U. GC-MS and HPLC analysis of crude extracts of stem bark of Adansonia digitata. bayero. J. Pure Appl. Sci. 10, 155–161 (2017).

    Google Scholar 

  39. Balouiri, M., Sadiki, M. & iIbnsouda, S. K. Methods for in vitro evaluating antimicrobial activity: A review. J. Pharm. Anal. 6, 71–79 (2016).

    Google Scholar 

  40. Traore, Y., Ouattara, K., Yeo, D., Doumbia, I. & Coulibaly, A. Investigation of the antifungal and antibacterial activities of the leaves of Annona senegalensis Pers. (Annonaceae). J. Appl. Biosci. 58, 4234–4242 (2012).

    Google Scholar 

  41. Fu, Y. et al. Lipid metabolism in cancer progression and therapeutic strategies. Med. Comm. 2 (1), 27–59 (2021).

    Google Scholar 

  42. TseteghoSokeng, A. J. et al. Metabolite characterization of powdered fruits and leaves from Adansonia digitata L. (baobab): a multi-methodological approach. Food Chem. 272, 93–108 (2019).

    Google Scholar 

  43. Vo, T. K., Ta, Q. T. H., Chu, Q. T., Nguyen, T. T. & Vo, V. G. Anti-Hepatocellular-Cancer activity exerted by β-Sitosterol and β-Sitosterol-Glucoside from Indigoferazollingeriana Miq. Molecules 25 (13), 3021 (2020).

    Google Scholar 

  44. Mohammed, B. Suliman* and Sanadelaslam El-Hddad characterization of chemical constituents of Adansonia digitata L. using GC-MS and LC-MS/QTOF and their in vitro Anti-cervical cancer effects Mohammed B. Suliman* and Sanadelaslam El-Hddad trop. J. Nat. Prod. Res. June. 7 (6), 3191–3197 (2023).

    Google Scholar 

  45. Sharma, S., Shukla, V. & Janardan Similarity and docking analysis of bioactive compounds from Adansonia digitata L. against vascular endothelial growth factor receptor—An in silico approach. J. Drug Res. Ayurvedic Sci. 8 (1), 55–64. (2023). Jan–Mar.

    Google Scholar 

  46. Rouamba, et al. Phytochemical screening, antioxidant and cytoprotective activities of fruits pulp extracts from Adansonia digitata L. (bombacaceae) and Ziziphus Mauritiana lam. Int. J. Pharm. Sci. Res. 13(7), 2944–2950. (2022) (rhamnaceae).

    Google Scholar 

  47. Huiam Salah Eldeen IzzEldeenAbdAlaziz 1and Mona, Mageed, A. M. & Analysis, P. Antioxidant Activity and Cytotoxicity of Adansonia digitataL. Seeds Ethanol Extract, Excellence Journal for Medical Sciences, 1(1) (2019).

  48. Awad, M. A. et al., H. Al-Shehri5 and R. Ramadan, Comparative analysis Adansonia digitata nanoparticle and encapsulation: synthesis, characterization, antimicrobial and anticancer assessment, J. Anim. Plant Sci., 35(1), 49–57. (2025).

  49. Bello, O. K., Oloyede, H. O. B., Salawu, M. O. & Yakubu, M. T. Protective and ameliorative effects of Adansonia digitata and Corchorus olitorius Leaves-based diet on Gamma-irradiation induced genotoxicity and p53 damage in cellular system of rats. Nig J. Pure Appl. Sci. 36 (Issue 2), 4607–4623 (2023).

    Google Scholar 

Download references