Self-propelled platinum based magnetite Janus nanomotors prepared from PCL and PHEMA graft copolymer with physicochemical properties motility and peroxidase-like activity

self-propelled-platinum-based-magnetite-janus-nanomotors-prepared-from-pcl-and-phema-graft-copolymer-with-physicochemical-properties-motility-and-peroxidase-like-activity
Self-propelled platinum based magnetite Janus nanomotors prepared from PCL and PHEMA graft copolymer with physicochemical properties motility and peroxidase-like activity
  • Xia, Q.-s, Ding, H.-m & Ma, Y.-q. Can dual-ligand targeting enhance cellular uptake of nanoparticles?. Nanoscale 9(26), 8982–8989 (2017).

    Google Scholar 

  • Wang, Z. et al. Active targeting theranostic iron oxide nanoparticles for MRI and magnetic resonance-guided focused ultrasound ablation of lung cancer. Biomaterials 127, 25–35 (2017).

    Google Scholar 

  • Rabha, B. et al. Development of polymer-based nanoformulations for glioblastoma brain cancer therapy and diagnosis: An update. Polymers 13 (23), 4114 (2021).

    Google Scholar 

  • Xue, X. et al. Trojan Horse nanotheranostics with dual transformability and multifunctionality for highly effective cancer treatment. Nat. Commun. 9 (1), 3653 (2018).

    Google Scholar 

  • Zhao, N., Woodle, M. C. & Mixson, A. J. Advances in delivery systems for doxorubicin. J. Nanomed. Nanatechnol. 9 (5), 519 (2018).

    Google Scholar 

  • Ali, B. H. et al. Active targeted delivery of theranostic thermo/pH dual-responsive magnetic Janus nanoparticles functionalized with folic acid/fluorescein ligands for enhanced DOX combination therapy of rat glioblastoma. J. Mater. Chem. B. 12 (24), 5957–5973 (2024).

    Google Scholar 

  • Koumura, N. et al. Light-driven monodirectional molecular rotor. Nature 401 (6749), 152–155 (1999).

    Google Scholar 

  • Liu, H. et al. Theranostic nanomotors for tumor multimode imaging and photothermal/photodynamic synergistic therapy. Chem. Eng. J. 442, 135994 (2022).

    Google Scholar 

  • Zhang, Y. & Hess, H. Chemically-powered swimming and diffusion in the microscopic world. Nat. Rev. Chem. 5(7), 500–510 (2021).

    Google Scholar 

  • Fu, S. et al. An efficient enzyme-powered micromotor device fabricated by cyclic alternate hybridization assembly for DNA detection. Nanoscale 9 (26), 9026–9033 (2017).

    Google Scholar 

  • Tang, S. et al. Enzyme-powered Janus platelet cell robots for active and targeted drug delivery. Sci. Rob. 5 (43), eaba6137 (2020).

    Google Scholar 

  • de Ávila, B. E. F. et al. Micromotor-enabled active drug delivery for in vivo treatment of stomach infection. Nat. Commun. 8 (1), 272 (2017).

    Google Scholar 

  • Kong, L. et al. Micromotor-assisted human serum glucose biosensing. Anal. Chem. 91 (9), 5660–5666 (2019).

    Google Scholar 

  • Feng, Y. et al. Self-adaptive enzyme-powered micromotors with switchable propulsion mechanism and motion directionality.. Appl. Phys. Rev. 8 (1), 011406 https://doi.org/10.1063/5.0029060 (2021).

    Google Scholar 

  • Tu, Y. et al. Self-propelled supramolecular nanomotors with temperature-responsive speed regulation. Nat. Chem. 9 (5), 480–486 (2017).

    Google Scholar 

  • Ji, Y. et al. Thermoresponsive polymer brush modulation on the direction of motion of phoretically driven Janus micromotors. Angew. Chem. 131 (13), 4228–4232 (2019).

    Google Scholar 

  • Wu, Z. et al. Recent progress on bioinspired self-propelled micro/nanomotors via controlled molecular self‐assembly. Small 12 (23), 3080–3093 (2016).

    Google Scholar 

  • Ma, H. et al. Janus micro/nanomotors for enhanced disease treatment through their deep penetration capability.. Acta Biomater. 196 50-77 https://doi.org/10.1016/j.actbio.2025.02.055 (2025).

    Google Scholar 

  • Fernández-Medina, M. et al. Recent advances in nano‐and micromotors. Adv. Funct. Mater. 30 (12), 1908283 (2020).

    Google Scholar 

  • Wilson, D. A., Nolte, R. J. & Van Hest, J. C. Autonomous movement of platinum-loaded stomatocytes. Nat. Chem. 4 (4), 268–274 (2012).

    Google Scholar 

  • Abdelmohsen, L. K. et al. Micro-and nano-motors for biomedical applications. J. Mater. Chem. B. 2 (17), 2395–2408 (2014).

    Google Scholar 

  • Ismagilov, R. F. et al. Autonomous movement and self-assembly. Angew. Chem. Int. Ed. 41 (4), 652–654 (2002).

    Google Scholar 

  • Sánchez, S., Soler, L. & Katuri, J. Chemically powered micro-and nanomotors. Angew. Chem. Int. Ed. 54 (5), 1414–1444 (2015).

    Google Scholar 

  • Guo, J. et al. Theranostic unimolecular micelles based on brush-shaped amphiphilic block copolymers for tumor-targeted drug delivery and positron emission tomography imaging. ACS Appl. Mater. Interfaces. 6 (24), 21769–21779 (2014).

    Google Scholar 

  • Eatemadi, A. et al. Comparison, synthesis and evaluation of anticancer drug-loaded polymeric nanoparticles on breast cancer cell lines.. Artif. Cells Nanomed. Biotechnol. 44(3), 1008–1017 (2016).

    Google Scholar 

  • Kefayat, A. et al. Ultra-small but ultra-effective: Folic acid-targeted gold nanoclusters for enhancement of intracranial glioma tumors’ radiation therapy efficacy. Nanomed. Nanotechnol. Biol. Med. 16, 173–184 (2019).

    Google Scholar 

  • Tacar, O., Sriamornsak, P. & Dass, C. R. Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems. J. Pharm. Pharmacol. 65 (2), 157–170 (2013).

    Google Scholar 

  • Zhao, N., Woodle, M. C. & Mixson, A. J. Advances in delivery systems for doxorubicin. J. Nanomed. Nanatechnol., 9(5). (2018).

  • Makwana, V. et al. Liposomal doxorubicin as targeted delivery platform: Current trends in surface functionalization. Int. J. Pharm. 593, 120117 (2021).

    Google Scholar 

  • Tu, F., Park, B. J. & Lee, D. Thermodynamically stable emulsions using Janus dumbbells as colloid surfactants. Langmuir 29 (41), 12679–12687 (2013).

    Google Scholar 

  • Fernandez-Rodriguez, M. A. et al. Surface activity of Janus particles adsorbed at fluid–fluid interfaces: Theoretical and experimental aspects. Adv. Colloid Interface Sci. 233, 240–254 (2016).

    Google Scholar 

  • Fan, H. & Striolo, A. Mechanistic study of droplets coalescence in Pickering emulsions. Soft Matter. 8 (37), 9533–9538 (2012).

    Google Scholar 

  • Wu, D., Binks, B. P. & Honciuc, A. Modeling the interfacial energy of surfactant-free amphiphilic Janus nanoparticles from phase inversion in Pickering emulsions. Langmuir 34 (3), 1225–1233 (2018).

    Google Scholar 

  • Yánez-Sedeño, P., Campuzano, S. & Pingarrón, J. Janus particles for (bio) sensing. Appl. Mater. Today. 9, 276–288 (2017).

    Google Scholar 

  • Wang, C. et al. Bioengineering of artificial antigen presenting cells and lymphoid organs. Theranostics 7 (14), 3504 (2017).

    Google Scholar 

  • Lee, K. et al. Rupture of lipid membranes induced by amphiphilic Janus nanoparticles. ACS Nano 12(4), 3646–3657 (2018).

    Google Scholar 

  • Khoee, S. & Soleymani, M. Janus arrangement of smart polymer on magnetite nanoparticles through solvent evaporation from emulsion droplets. Appl. Surf. Sci. 494, 805–816 (2019).

    Google Scholar 

  • Soleymani, M. et al. Tuning the motion velocity of enzyme-driven dextran/polyacrylamide Janus nanomotors by incorporating the thermo-switchable PNIPAM moieties in their structure. Eur. Polymer J. 194, 112113 (2023).

    Google Scholar 

  • Khoee, S., Moayeri, S. & Charsooghi, M. A. Self-/Magnetic-propelled catalytic nanomotors based on a Janus SPION@ PEG-Pt/PCL hybrid nanoarchitecture: Single-particle versus collective motions. Langmuir 37(36), 10668–10682 (2021).

    Google Scholar 

  • Fedeli, C. et al. The functional dissection of the plasma corona of SiO 2-NPs spots histidine rich glycoprotein as a major player able to hamper nanoparticle capture by macrophages. Nanoscale 7 (42), 17710–17728 (2015).

    Google Scholar 

  • Trinh, D. N. et al. Nanoparticle biomolecular corona-based enrichment of plasma glycoproteins for N-glycan profiling and application in biomarker discovery. ACS Nano 16(4), 5463–5475 (2022).

    Google Scholar 

  • Nogueira, J. et al. Magnetic driven nanocarriers for pH-responsive doxorubicin release in cancer therapy. Molecules 25 (2), 333 (2020).

    Google Scholar 

  • Palanikumar, L. et al. pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics. Commun. biology. 3 (1), 95 (2020).

    Google Scholar 

  • Zhang, X., Lin, Y. & Gillies, R. J. Tumor pH and its measurement. J. Nucl. Med. 51 (8), 1167–1170 (2010).

    Google Scholar 

  • Feng, L. et al. The acidic tumor microenvironment: a target for smart cancer nano-theranostics. Natl. Sci. Rev. 5 (2), 269–286 (2018).

    Google Scholar 

  • Lin, B. et al. Acidic pH and high-H2O2 dual tumor microenvironment-responsive nanocatalytic graphene oxide for cancer selective therapy and recognition. ACS Appl. Mater. Interfaces. 11 (12), 11157–11166 (2019).

    Google Scholar 

  • Shirvalilou, S. et al. Targeted magnetochemotherapy modified by 5-Fu-loaded thermally on/off switching nanoheaters for the eradication of CT26 murine colon cancer by inducing apoptotic and autophagic cell death. Cancer Nanotechnol. 14 (1), 11 (2023).

    Google Scholar 

  • Miyoshi, S. et al. Transfection of neuroprogenitor cells with iron nanoparticles for magnetic resonance imaging tracking: cell viability, differentiation, and intracellular localization. Mol. Imaging Biology. 7, 286–295 (2005).

    Google Scholar 

  • Ma, M. et al. Fe3O4@ Pt nanoparticles with enhanced peroxidase-like catalytic activity. Mater. Lett. 105, 36–39 (2013).

    Google Scholar 

  • Chen, S. et al. Nanomotors: 20 years anniversary and future roadmap. (2025).

  • Ruiz-Gonzalez, N. et al. Micro-and Nanomotors: Engineered Tools for Targeted and Efficient Biomedicine. ACS nano. 19 (9), 8411–8432 (2025).

    Google Scholar 

  • Hasan-Nasab, B. et al. A promising targeting system to enrich irinotecan antitumor efficacy: Folic acid targeted nanoparticles. J. Drug Deliv. Sci. Technol. 63, 102543 (2021).

    Google Scholar 

  • Feng, N., Liang, L. & Liu, Y. Engineering Cup-Shaped Nanomotors Promoting Cell. Internalization Synergistic Tumor Therapy Res., 8: 0623. (2025).

    Google Scholar 

  • Sakulkhu, U. et al. Protein corona composition of superparamagnetic iron oxide nanoparticles with various physico-chemical properties and coatings. Sci. Rep. 4 (1), 5020 (2014).

    Google Scholar 

  • Dutz, S. et al. Influence of sterilization and preservation procedures on the integrity of serum protein-coated magnetic nanoparticles. Nanomaterials 7 (12), 453 (2017).

    Google Scholar 

  • Creixell, M. et al. EGFR-targeted magnetic nanoparticle heaters kill cancer cells without a perceptible temperature rise. ACS Nano 5(9), 7124–7129 (2011).

    Google Scholar 

  • Hervault, A. et al. Doxorubicin loaded dual pH-and thermo-responsive magnetic nanocarrier for combined magnetic hyperthermia and targeted controlled drug delivery applications. Nanoscale 8 (24), 12152–12161 (2016).

    Google Scholar 

  • Rahimi, M. In vitro evaluation of novel polymer-coated magnetic nanoparticles for controlled drug delivery. In Nanomedicine in Cancer 623–645 (Jenny Stanford Publishing, 2017).

  • Reyes-Ortega, F. et al. Hyperthermia-triggered doxorubicin release from polymer-coated magnetic nanorods. Pharmaceutics 11 (10), 517 (2019).

    Google Scholar 

  • Kalındemirtaş, F. D., Cilasun, G. E. & Kariper, A. Enhanced therapeutic efficacy of platinum-doxorubicin nanoparticles on colon and breast cancer cell lines.. Naunyn-Schmiedeberg’s Arch. Pharmacol. https://doi.org/10.1007/s00210-025-04080-4 (2025).

    Google Scholar 

  • Norouzi, M. et al. Doxorubicin-loaded iron oxide nanoparticles for glioblastoma therapy: A combinational approach for enhanced delivery of nanoparticles. Sci. Rep. 10 (1), 11292 (2020).

    Google Scholar 

  • Shen, C. et al. Doxorubicin and indocyanine green loaded superparamagnetic iron oxide nanoparticles with PEGylated phospholipid coating for magnetic resonance with fluorescence imaging and chemotherapy of glioma.. Int. J. Nanomed. 20(14)https://doi.org/10.2147/IJN.S173954 (2019).

    Google Scholar 

  • Gülden, M. et al. Cytotoxic potency of H2O2 in cell cultures: impact of cell concentration and exposure time. Free Radic. Biol. Med. 49 (8), 1298–1305 (2010).

    Google Scholar 

  • Zhang, W. et al. Oxygen-generating MnO2 nanodots‐anchored versatile nanoplatform for combined chemo‐photodynamic therapy in hypoxic cancer. Adv. Funct. Mater. 28 (13), 1706375 (2018).

    Google Scholar 

  • Paxton, W. F. et al. Catalytic nanomotors: autonomous movement of striped nanorods. J. Am. Chem. Soc. 126 (41), 13424–13431 (2004).

    Google Scholar 

  • Díez, P. et al. Ultrafast directional Janus Pt–mesoporous silica nanomotors for smart drug delivery. ACS Nano 15(3), 4467–4480 (2021).

    Google Scholar 

  • Karimi, M. R., Khoee, S. & Shaghaghi, B. Smart transformation of bowl shape chitosan nanomotors to disc shape in simulated biological media and consequent controlled velocity. J. Drug Deliv. Sci. Technol. 80, 104096 (2023).

    Google Scholar 

  • Semkina, A. et al. Core–shell–corona doxorubicin-loaded superparamagnetic Fe3O4 nanoparticles for cancer theranostics. Colloids Surf., B. 136, 1073–1080 (2015).

    Google Scholar 

  • Saul, J. M. et al. Controlled targeting of liposomal doxorubicin via the folate receptor in vitro. J. Controlled Release. 92 (1–2), 49–67 (2003).

    Google Scholar 

  • Lu, Y. J. et al. Dual targeted delivery of doxorubicin to cancer cells using folate-conjugated magnetic multi-walled carbon nanotubes. Colloids Surf., B. 89, 1–9 (2012).

    Google Scholar 

  • Wang, Y. X. J. Superparamagnetic iron oxide based MRI contrast agents: Current status of clinical application. Quant. imaging Med. Surg. 1 (1), 35 (2011).

    Google Scholar 

  • Özçelik, S. et al. Structure, magnetic, photocatalytic and blood compatibility studies of nickel nanoferrites prepared by laser ablation technique in distilled water. J. Alloys Compd. 854, 157279 (2021).

    Google Scholar 

  • Guo, Y. et al. Construction of intelligent moving micro/nanomotors and their applications in biosensing and disease treatment. Theranostics 13 (9), 2993 (2023).

    Google Scholar 

  • Wei, H. & Wang, E. Fe3O4 magnetic nanoparticles as peroxidase mimetics and their applications in H2O2 and glucose detection. Anal. Chem. 80 (6), 2250–2254 (2008).

    Google Scholar 

  • He, S. B. et al. Sodium alginate modified platinum nanozymes with highly efficient and robust oxidase-like activity for antioxidant capacity and analysis of proanthocyanidins. Front. Chem. 8, 654 (2020).

    Google Scholar 

  • Deng, H. et al. Biomineralization synthesis of a near-infrared fluorescent nanoprobe for direct glucose sensing in whole blood. Nanoscale 12 (2), 864–870 (2020).

    Google Scholar 

  • Gao, L. et al. Intrinsic peroxidase-like activity of ferromagnetic nanoparticles. Nat. Nanotechnol. 2 (9), 577–583 (2007).

    Google Scholar 

  • Hasan, Y. R. et al. Iron oxide nanoparticles: biosynthesis, peroxidase-like activity, and biosafety. Appl. Microbiol. Biotechnol. 109 (1), 1–29 (2025).

    Google Scholar 

  • Lai, X. et al. Synthesis of PDA-mediated magnetic bimetallic nanozyme and its application in immunochromatographic assay. ACS Appl. Mater. Interfaces. 13 (1), 1413–1423 (2020).

    Google Scholar 

  • Vallabani, N. S., Singh, S. & Karakoti, A. S. Investigating the role of ATP towards amplified peroxidase activity of Iron oxide nanoparticles in different biologically relevant buffers. Appl. Surf. Sci. 492, 337–348 (2019).

    Google Scholar 

  • Monopoli, M. P. et al. Biomolecular coronas provide the biological identity of nanosized materials. Nano-enabled Med. Appl.7(12) pp. 205–229. (2020).

  • Nierenberg, D., Khaled, A. R. & Flores, O. Formation of a protein corona influences the biological identity of nanomaterials. Rep. Pract. Oncol. Radiother. 23(4), 300–308 (2018).

    Google Scholar 

  • Zeng, X. et al. Blood-triggered generation of platinum nanoparticle functions as an anti-cancer agent. Nat. Commun. 11 (1), 567 (2020).

    Google Scholar