Sustainable development of novel zinc oxide nano flowers mediated red yeast rice for control of hepatocellular carcinoma

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Sustainable development of novel zinc oxide nano flowers mediated red yeast rice for control of hepatocellular carcinoma

References

  1. Chakraborty, E. & Sarkar, D. Emerging Therapies for Hepatocellular Carcinoma (HCC). Cancers (Basel). 14, 2798 (2022).

  2. Khorrami, S., Zarrabi, A., Khaleghi, M., Danaei, M. & Mozafari, M. R. Selective cytotoxicity of green synthesized silver nanoparticles against the MCF-7 tumor cell line and their enhanced antioxidant and antimicrobial properties. Int. J. Nanomed. 13, 8013–8024 (2018).

    Google Scholar 

  3. Khorrami, S., Zarepour, A. & Zarrabi, A. Green synthesis of silver nanoparticles at low temperature in a fast Pace with unique DPPH radical scavenging and selective cytotoxicity against MCF-7 and BT-20 tumor cell lines. Biotechnol. Rep. 24, e00393 (2019).

    Google Scholar 

  4. Khorrami, S. et al. An improved method for fabrication of Ag-GO nanocomposite with controlled Anti-Cancer and Anti-bacterial Behavior; A comparative study. Sci. Rep. 9, 9167 (2019).

    Google Scholar 

  5. Carofiglio, M., Barui, S., Cauda, V. & Laurenti, M. Doped zinc oxide nanoparticles: synthesis, characterization and potential use in nanomedicine. Appl. Sci. (Basel Switzerland). 10, 5194 (2020).

    Google Scholar 

  6. Prasad, R. D. et al. A review on concept of nanotechnology in veterinary medicine. ES Food Agrofor. 4, 28–60 (2021).

    Google Scholar 

  7. Mandal, A. K. et al. Current research on zinc oxide nanoparticles: synthesis, characterization, and biomedical applications. Nanomaterials 12, 3066 (2022).

    Google Scholar 

  8. Lata, C. et al. Springer,. in Cereal Dis. nanobiotechnological approaches diagnosis Manag. 345–370 (2022).

  9. Jiang, J., Pi, J. & Cai, J. The advancing of zinc oxide nanoparticles for biomedical applications. Bioinorg. Chem. Appl. 1062562 (2018).

  10. Vinay, S. P., Udayabhanu, Nagaraju, G., Chandrappa, C. P. & Chandrasekhar, N. Novel Gomutra (cow urine) mediated synthesis of silver oxide nanoparticles and their enhanced photocatalytic, photoluminescence and antibacterial studies. J. Sci. Adv. Mater. Devices. 4, 392–399 (2019).

    Google Scholar 

  11. Vinay, S. P., Udayabhanu, Nagarju, G., Chandrappa, C. P. & Chandrasekhar, N. Enhanced photocatalysis, photoluminescence, and anti-bacterial activities of nanosize ag: green synthesized via Rauvolfia tetraphylla (devil pepper). SN Appl. Sci. 1, 477 (2019).

    Google Scholar 

  12. Vinay, S. P., Alharthi, F. A., Udayabhanu, Alsalme, A. & Nagaraju, G. Hydrothermal synthesis of Ag/rGO@CTFE nanocomposite as a promising photocatalyst for degradation action. J. Mol. Struct. 1228, 129722 (2021).

    Google Scholar 

  13. Vinay, S. P., Udayabhanu, Nagaraju, G., Chandrappa, C. P. & Chandrasekhar, N. Hydrothermal synthesis of gold nanoparticles using spider cobweb as novel biomaterial: application to photocatalytic. Chem. Phys. Lett. 748, 137402 (2020).

    Google Scholar 

  14. s p, V., Udayabhanu, U., Lalithamba, G. N., N, C. & H. S. & Plant-mediated green synthesis of ag nanoparticles using Rauvolfia tetraphylla (L) flower extracts:Characterization, biological activities, and screening of the catalytic activity in formylation reaction. Sci. Iran. 27, 3353–3366 (2020).

    Google Scholar 

  15. Anjum, S. et al. Recent advances in zinc oxide nanoparticles (ZnO NPs) for cancer diagnosis, target drug delivery, and treatment. Cancers (Basel). 13, 4570 (2021).

    Google Scholar 

  16. Ferrag, C. Development of Nanocomposite Gels for Electrochemical Sensors and Energy Applications. at (2023).

  17. El-Sayed, E. S. R., El-Sayyad, G. S., Abdel-Fatah, S. S., El-Batal, A. I. & Boratyński, F. Novel nanoconjugates of metal oxides and natural red pigment from the endophyte monascus ruber using solid-state fermentation. Microb. Cell. Fact. 23, 259 (2024).

    Google Scholar 

  18. Irede, E. L. et al. Cutting-edge developments in zinc oxide nanoparticles: synthesis and applications for enhanced antimicrobial and UV protection in healthcare solutions. RSC Adv. 14, 20992–21034 (2024).

    Google Scholar 

  19. Mostafa, H., Airouyuwa, J. O. & Maqsood, S. A novel strategy for producing nano-particles from date seeds and enhancing their phenolic content and antioxidant properties using ultrasound-assisted extraction: A multivariate based optimization study. Ultrason. Sonochem. 87, 106017 (2022).

    Google Scholar 

  20. Khan, I., Saeed, K. & Khan, I. Nanoparticles: Properties, applications and toxicities. Arab. J. Chem. 12, 908–931 (2019).

  21. Adebare, J. A. & Bioethanol production from pretreated sugarcane bagasse under optimised conditions using selected fungi. at (2021).

  22. Younas, Z. et al. Mechanistic approaches to the application of nano-zinc in the poultry and biomedical industries: A comprehensive review of future perspectives and challenges. Molecules 28, 1064 (2023).

    Google Scholar 

  23. Wu, Z., Yang, S. & Wu, W. Shape control of inorganic nanoparticles from solution. Nanoscale 8, 1237–1259 (2016).

    Google Scholar 

  24. Singh, T. A. et al. A state of the Art review on the synthesis, antibacterial, antioxidant, antidiabetic and tissue regeneration activities of zinc oxide nanoparticles. Adv. Colloid Interface Sci. 295, 102495 (2021).

    Google Scholar 

  25. Mousavi, S. M. et al. Shape-controlled synthesis of zinc nanostructures mediating macromolecules for biomedical applications. Biomater. Res. 26, 4 (2022).

    Google Scholar 

  26. Jin, S. E. & Jin, H. E. Antimicrobial activity of zinc oxide nano/microparticles and their combinations against pathogenic microorganisms for biomedical applications: From physicochemical characteristics to pharmacological aspects. nanomaterials 11, 263 (2021).

  27. Kadhim, A. A. et al. Investigating the effects of biogenic zinc oxide nanoparticles produced using papaver somniferum extract on oxidative stress, cytotoxicity, and the induction of apoptosis in the THP-1 cell line. Biol. Trace Elem. Res. 201, 4697–4709 (2023).

    Google Scholar 

  28. Neamah, S. A., Albukhaty, S., Falih, I. Q., Dewir, Y. H., & Mahood, H. B. (2023). Biosynthesis of zinc oxide nanoparticles using Capparis spinosa L. fruit extract: characterization, biocompatibility, and antioxidant activity. Appl. Sci. 13 (11), 6604.

  29. Altammar, K. A. A review on nanoparticles: characteristics, synthesis, applications, and challenges. Front. Microbiol. 14, 1155622 (2023).

    Google Scholar 

  30. Vinay, S. P., Chandrasekhar, N. & Chandrappa, C. P. Eco-friendly approach for the green synthesis of silver nanoparticles using flower extracts of sphagneticola trilobata and study of antibacterial activity. Int. J. Pharm. Biol. Sci. 7, 145–152 (2017).

    Google Scholar 

  31. Chandrasekhar, N. & Vinay, S. P. Yellow colored blooms of argemone Mexicana and Turnera ulmifolia mediated synthesis of silver nanoparticles and study of their antibacterial and antioxidant activity. Appl. Nanosci. 7, 851–861 (2017).

    Google Scholar 

  32. Vinay, S. P. & Chandrasekhar, N. Characterization and green synthesis of silver nanoparticles from plumeria leaves extracts: study of their antibacterial activity. IOSR-JAC 10, 57–63 (2017).

    Google Scholar 

  33. Raha, S. & Ahmaruzzaman, M. ZnO nanostructured materials and their potential applications: progress, challenges and perspectives. Nanoscale Adv. 4, 1868–1925 (2022).

    Google Scholar 

  34. Malik, P., Rani, R., Khan, S., Fernandes, D. & Mukherjee, T. K. Green essence of plant resources capped zinc oxide nanoparticles: renewable Distinctions, Size-Shape‐Modulated physicochemical diversity and emerging Biomedical‐Environmental usefulness. Part. Part. Syst. Charact. 42, 2400145 (2025).

    Google Scholar 

  35. Vinay, S. P. & Chandrasekhar, N. Structural and biological investigation of green synthesized silver and zinc oxide nanoparticles. J. Inorg. Organomet. Polym. Mater. 31, 552–558 (2021).

    Google Scholar 

  36. Vinay, S. P. et al. Facile combustion synthesis of Ag2O nanoparticles using cantaloupe seeds and their multidisciplinary applications. Appl. Organomet. Chem. 34, e5830 (2020).

    Google Scholar 

  37. Ali, A., Phull, A. R. & Zia, M. Elemental zinc to zinc nanoparticles: is ZnO NPs crucial for life? Synthesis, toxicological, and environmental concerns. Nanotechnol Rev. 7, 413–441 (2018).

    Google Scholar 

  38. Ibrahim, A. B. M. & Mahmoud, G. A. Chemical-vs sonochemical‐assisted synthesis of ZnO nanoparticles from a new zinc complex for improvement of carotene biosynthesis from Rhodotorula toruloides MH023518. Appl. Organomet. Chem. 35, e6086 (2021).

    Google Scholar 

  39. Harish, V. et al. Cutting-edge advances in tailoring size, shape, and functionality of nanoparticles and nanostructures: A review. J. Taiwan. Inst. Chem. Eng. 149, 105010 (2023).

    Google Scholar 

  40. Terna, A. D., Elemike, E. E., Mbonu, J. I., Osafile, O. E. & Ezeani, R. O. The future of semiconductors nanoparticles: Synthesis, properties and applications. Mater. Sci. Eng. B. 272, 115363 (2021).

    Google Scholar 

  41. Vinay, S. P., Sumedha, H. N., Shashank, M., Nagaraju, G. & Chandrasekhar, N. In-vitro antibacterial, antioxidant and cytotoxic potential of gold nanoparticles synthesized using novel Elaeocarpus Ganitrus seeds extract. J. Sci. Adv. Mater. Devices. 6, 127–133 (2021).

    Google Scholar 

  42. Vinay, S. P., Udayabhanu, Nagaraju, G., Chandrappa, C. P. & Chandrasekhar, N. Rauvolfia tetraphylla (devil pepper)-mediated green synthesis of ag nanoparticles: applications to anticancer, antioxidant and antimitotic. J. Clust Sci. 30, 1545–1564 (2019).

    Google Scholar 

  43. Vinay, S. P., Udayabhanu, Nagaraju, G., Chandrappa, C. P. & Chandrasekhar, N. A novel, green, rapid, nonchemical route hydrothermal assisted biosynthesis of ag nanomaterial by Blushwood berry extract and evaluation of its diverse applications. Appl. Nanosci. 10, 3341–3351 (2020).

    Google Scholar 

  44. Mohammed, T. J. & Al-Shibly, M. K. Therapeutic effect of biosynthesis of selenium nanoparticles on enhancing apoptosis induction and cell lines arrest in MCF-7 breast cancer cell lines. J. Nanostruct. 13, 796–805 (2023).

    Google Scholar 

  45. Carreno, E. A. et al. Considerations and technical pitfalls in the employment of the MTT assay to evaluate photosensitizers for photodynamic therapy. Appl. Sci. 11, 2603 (2021).

    Google Scholar 

  46. Jyothish, B. & Jacob, J. In vitro antiproliferative and G0/G1 cell cycle arrest in human lung carcinoma cells by ag doped zinc ferrite nanoparticles. Inorg. Chem. Commun. 153, 110869 (2023).

    Google Scholar 

  47. Jabir, M. S. et al. Functionalized SWCNTs@ Ag–TiO2 nanocomposites induce ROS-mediated apoptosis and autophagy in liver cancer cells. Nanotechnol Rev. 12, 20230127 (2023).

    Google Scholar 

  48. Sasaki, D., Abe, J., Takeda, A., Harashima, H. & Yamada, Y. Transplantation of MITO cells, mitochondria activated cardiac progenitor cells, to the ischemic myocardium of mouse enhances the therapeutic effect. Sci. Rep. 12, 4344 (2022).

    Google Scholar 

  49. Jun, H. K., Jung, Y. J., Ji, S., An, S. J. & Choi, B. K. Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts. Cell. Death Differ. 25, 380–391 (2018).

    Google Scholar 

  50. Hu, G. et al. Effects of matrine in combination with cisplatin on liver cancer. Oncol. Lett. 21, 66 (2021).

    Google Scholar 

  51. El-Saadony, M. T. et al. Green synthesis of zinc oxide nanoparticles: preparation, characterization, and biomedical applications-a review. Int. J. Nanomed. 12889–12937 (2024).

  52. Nandhini, J., Karthikeyan, E. & Rajeshkumar, S. Green synthesis of zinc oxide nanoparticles: eco-friendly advancements for biomedical marvels. Resour. Chem. Mater. 3, 294–316 (2024).

    Google Scholar 

  53. Sanaeimehr, Z., Javadi, I. & Namvar, F. Antiangiogenic and antiapoptotic effects of green-synthesized zinc oxide nanoparticles using sargassum muticum algae extraction. Cancer Nanotechnol. 9, 3 (2018).

    Google Scholar 

  54. Khan, M. J., Ahmad, A., Khan, M. A. & Siddiqui, S. Zinc oxide nanoparticle induces apoptosis in human epidermoid carcinoma cells through reactive oxygen species and DNA degradation. Biol. Trace Elem. Res. 199, 2172–2181 (2021).

    Google Scholar 

  55. Zargarnezhad, M., Mirbahari, S. N. & Ahmadi, R. The cytotoxic effects of zinc oxide nanoparticles on SW480 cell lines and measurement of nitric oxide in cell culture medium. Jentashapir J. Cell. Mol. Biol. 13, 1–7 (2022).

    Google Scholar 

  56. Ibraheem, S., Kadhim, A. A., Kadhim, K. A., Kadhim, I. A. & Jabir, M. Zinc Oxide Nanoparticles as Diagnostic Tool for Cancer Cells. Int. J. Biomater. (2022). 

  57. Son, N. N., Thanh, V. M. & Huong, N. T. Anticancer Activities of Zinc Oxide Nanoparticles Synthesized Using Guava Leaf extract. ChemistrySelect 8, e202303214 (2023).

  58. Perumal, P. et al. Green synthesis of zinc oxide nanoparticles using aqueous extract of Shilajit and their anticancer activity against HeLa cells. Sci. Rep. 14, 2204 (2024).

    Google Scholar 

  59. Hadi, A. J., Nayef, U. M., Mutlak, F. A., Jabir, M. S., & Muayad, M. W. Antibacterial and anticancer properties of zinc oxide nanoparticles: A review of current advances and future directions. J. Appl. Sci. Nanotechnol. 5 (3), 60–87 (2025).

  60. Aljohar, A. Y. et al. Anticancer effect of zinc oxide nanoparticles prepared by varying entry time of ion carriers against A431 skin cancer cells in vitro. Front. Chem. 10, 1069450 (2022).

  61. Mousa, A. B., Moawad, R., Abdallah, Y., Abdel-Rasheed, M. & Zaher, A. M. A. Zinc oxide nanoparticles promise anticancer and antibacterial activity in ovarian cancer. Pharm. Res. 40, 2281 (2023).

    Google Scholar 

  62. Mongy, Y. & Shalaby, T. Green synthesis of zinc oxide nanoparticles using Rhus coriaria extract and their anticancer activity against triple-negative breast cancer cells. Sci. Rep. 14, 13470 (2024).

    Google Scholar 

  63. Ayub, H. et al. Enhanced anticancer and biological activities of environmentally friendly Ni/Cu-ZnO solid solution nanoparticles. Heliyon 10 (23), 39912 (2024).

  64. Al-darwesh, M. Y., Ibrahim, S. S. & Mohammed, M. A. A review on plant extract mediated green synthesis of zinc oxide nanoparticles and their biomedical applications. Results Chem. 7, 101368 (2024).

    Google Scholar 

  65. Naiel, B., Fawzy, M., Halmy, M. W. A. & Mahmoud, A. E. D. Green synthesis of zinc oxide nanoparticles using sea lavender (Limonium pruinosum L. Chaz.) extract: characterization, evaluation of anti-skin cancer, antimicrobial and antioxidant potentials. Sci. Rep. 12, 20370 (2022).

    Google Scholar 

  66. Karam, S. T. & Abdulrahman, A. F. Green Synthesis and Characterization of ZnO Nanoparticles by Using Thyme Plant Leaf Extract. Photonics 9, 594. (2022).

  67. Kadir, N. H. A. et al. Evaluation of the Cytotoxicity, antioxidant Activity, and molecular Docking of biogenic zinc oxide nanoparticles derived from pumpkin seeds. Microsc Res. Tech. 87, 602–615 (2023).

    Google Scholar 

  68. Gharpure, S., Yadwade, R. & Ankamwar, B. Non-Antimicrobial and Non-Anticancer properties of ZnO nanoparticles biosynthesized using different plant parts of < i > Bixa Orellana. Acs Omega. 7, 1914–1933 (2022).

    Google Scholar 

  69. Sarani, M. et al. Biosynthesis of ZnO, Bi < sub > 2 O < sub > 3 and ZnO – Bi2O3 Bimetallic Nanoparticles and Their Cytotoxic and Antibacterial Effects. Chemistryopen 13, (2024).

  70. Fakhar-e-Alam, M. et al. Antitumor activity of zinc oxide nanoparticles fused with green extract of Nigella sativa. J. Saudi Chem. Soc. 28, 101814 (2024).

    Google Scholar 

  71. Akhtar, M. J., Alhadlaq, H. A., Alshamsan, A., Khan, M. A. M. & Ahamed, M. Aluminum doping tunes band gap energy level as well as oxidative stress-mediated cytotoxicity of ZnO nanoparticles in McF-7 cells. Sci. Rep. 5 (1), e13876 (2015).

  72. Ahamed, M., Akhtar, M. J., Khan, M. A. M. & Alhadlaq, H. A. Enhanced anticancer performance of Eco-Friendly-Prepared Mo-ZnO/Rgo nanocomposites: role of oxidative stress and apoptosis. Acs Omega. 7, 7103–7115 (2022).

    Google Scholar 

  73. Badawy, M., Salah, M., & Abdel‐Hamid, G. Anticancer approach of zinc oxide nanocomposite prepared by gamma radiation via induction of apoptosis and PGC‐1α pathways in hepatocellular carcinoma in rats. Appl. Organomet. Chem. 38 (1), e7294 (2023).

  74. Hamrayev, H., Shameli, K. & Korpayev, S. Green synthesis of zinc oxide nanoparticles and its biomedical applications: A review. J. Res. Nanosci. Nanotechnol. 1, 62–74 (2021).

    Google Scholar 

  75. Hussien, N. A., Khalil, M. A. E. F., Schagerl, M. & Ali, S. S. Green synthesis of zinc oxide nanoparticles as a promising nanomedicine approach for anticancer, antibacterial, and anti-inflammatory therapies. Int. J. Nanomed. 3, 4299–4317 (2025).

  76. Evawati, K. & Sutoyo, S. Synthesis and characterization of ZnO nanoparticles using the Duwet (Syzygium cumini) leaves extract as bioreductor. J. Pijar Mipa. 20, 168–172 (2025).

    Google Scholar 

  77. Fatoni, A., Afrizal, M. A., Rasyad, A. A. & Hidayat, N. i. ZnO nanoparticles and its interaction with chitosan: profile spectra and their activity against bacterial. JKPK (Jurnal Kim dan. Pendidik Kim. 6, 216 (2021).

    Google Scholar 

  78. Kumar, R. et al. Synthesis and characterization of ZnO nanoparticles and its application by sol-gel method. (2023). Authorea Preprints.

  79. Gond, A. K. et al. Fabrication and physiochemical characterization of zinc oxide nanoparticles via citric assisted auto combustion synthesis. Curr. Nanomater. 10, 86–91 (2025).

    Google Scholar 

  80. Chandrappa, K. G. & Venkatesha, T. V. Electrochemical synthesis and photocatalytic property of zinc oxide nanoparticles. Nano-Micro Lett. 4, 14–24 (2012).

    Google Scholar 

  81. Koli, K., Rohtela, K. & Meena, D. Comparative study and analysis of structural and optical properties of zinc oxide nanoparticles using Neem and mint extract prepared by green synthesis method. IOP Conf. Ser. Mater. Sci. Eng. 1248, 012065 (2022).

    Google Scholar 

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