Synthesis, characterization of Mg doped CuFe2O4 nanoparticles for potential anticancer applications

Posted on
synthesis,-characterization-of-mg-doped-cufe2o4-nanoparticles-for-potential-anticancer-applications
Synthesis, characterization of Mg doped CuFe2O4 nanoparticles for potential anticancer applications

References

  1. Yu, S. et al. Ferrite nanoparticles-based reactive oxygen species-mediated cancer therapy. Front. Chem. 9, 651053 (2021).

    Google Scholar 

  2. Force, L. M. et al. The global, regional, and national burden of cancer, 1990–2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023. Lancet 406 (10512), 1565–1586 (2025).

    Google Scholar 

  3. Shende, P. & Shah, P. Carbohydrate-based magnetic nanocomposites for effective cancer treatment. Int. J. Biol. Macromol. 175, 281–293 (2021).

    Google Scholar 

  4. Chenchula, S. et al. Combination Therapies for the Management of Cancer Immunotherapy, in Nanotechnology Based Strategies for Cancer Immunotherapy: Concepts, Design, and Clinical Applications. Springer. 103–144. (2025).

  5. Sitohy, B. et al. Early Actions of Anti–Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor Receptor Drugs on Angiogenic Blood Vessels. Am. J. Pathol. 187 (10), 2337–2347 (2017).

    Google Scholar 

  6. Sitohy, B. & El-Salhy, M. Changes in the colonic enteric nervous system in rats with chemically induced colon dysplasia and carcinoma. Acta Oncol. 41 (6), 543–549 (2002).

    Google Scholar 

  7. El-Salhy, M. & Sitohy, B. Triple therapy with octreotide, galanin and serotonin induces necrosis and increases apoptosis of a rat colon carcinoma. Regul. Pept. 108 (2–3), 55–62 (2002).

    Google Scholar 

  8. El-Salhy, M., Sitohy, B. & Norrgård, Ö. Triple therapy with octreotide, galanin, and serotonin reduces the size and blood vessel density and increases apoptosis of a rat colon carcinoma. Regul. Pept. 111 (1–3), 145–152 (2003).

    Google Scholar 

  9. Sitohy, B. & El-Salhy, M. A comparison between double and triple therapies of octreotide, galanin and serotonin on a rat colon carcinoma (Histology and histopathology, 2003).

  10. El-Salhy, M. & Sitohy, B. Colonic endocrine cells in rats with chemically induced colon carcinoma. Histol. Histopathol. 16 (3), 833–838 (2001).

    Google Scholar 

  11. Ghadiri, N. et al. Bioactive peptides: an alternative therapeutic approach for cancer management. Front. Immunol. 15, 1310443 (2024).

    Google Scholar 

  12. Pandey, A. Role of Cyclodextrins in Nanoparticle-Based Systems for Drug Delivery. The history of cyclodextrins, : pp. 305–343. (2020).

  13. Wang, Y. et al. Engineering ferrite nanoparticles with enhanced magnetic response for advanced biomedical applications. Mater. Today Adv. 8, 100119 (2020).

    Google Scholar 

  14. Sadhasivam, J. & Sugumaran, A. Magnetic nanocarriers: Emerging tool for the effective targeted treatment of lung cancer. J. Drug Deliv. Sci. Technol. 55, 101493 (2020).

    Google Scholar 

  15. Zhao, S. et al. Multifunctional magnetic iron oxide nanoparticles: an advanced platform for cancer theranostics. Theranostics 10 (14), 6278 (2020).

    Google Scholar 

  16. Amiri, M. et al. Hydrogel beads-based nanocomposites in novel drug delivery platforms: Recent trends and developments. Adv. Colloid Interface Sci. 288, 102316 (2021).

    Google Scholar 

  17. Avval, Z. M. et al. Introduction of magnetic and supermagnetic nanoparticles in new approach of targeting drug delivery and cancer therapy application. Drug Metab. Rev. 52 (1), 157–184 (2020).

    Google Scholar 

  18. Al-Rawi, N. N. et al. Magnetism in drug delivery: The marvels of iron oxides and substituted ferrites nanoparticles. Saudi Pharm. J. 28 (7), 876–887 (2020).

    Google Scholar 

  19. Tripathy, A., Nine, M. J. & Silva, F. S. Biosensing platform on ferrite magnetic nanoparticles: synthesis, functionalization, mechanism and applications. Adv. Colloid Interface Sci. 290, 102380 (2021).

    Google Scholar 

  20. Akhtar, M. F. et al. A comprehensive review on the applications of ferrite nanoparticles in the diagnosis and treatment of breast cancer. Med. Oncol. 41 (2), 53 (2024).

    Google Scholar 

  21. Nagarajan, V. & Thayumanavan, A. MgFe2O4 thin films for detection of ethanol and acetone vapours. Surf. Eng. 34 (9), 711–720 (2018).

    Google Scholar 

  22. Polat, K. & Yurdakoc, M. Solar decolorization of methylene blue by magnetic MgFe2O4-MWCNT/Ag3VO4 visible active photocatalyst. Water Air Soil Pollut. 229 (10), 331 (2018).

    Google Scholar 

  23. Henning, R. A. et al. Characterization of MFe2O4 (M = Mg, Zn) thin films prepared by pulsed laser deposition for photoelectrochemical applications. J. Phys. Chem. C. 123 (30), 18240–18247 (2019).

    Google Scholar 

  24. Joulaei, M., Hedayati, K. & Ghanbari, D. Investigation of magnetic, mechanical and flame retardant properties of polymeric nanocomposites: Green synthesis of MgFe2O4 by lime and orange extracts. Compos. Part. B: Eng. 176, 107345 (2019).

    Google Scholar 

  25. Jia, J. et al. Z-scheme MgFe2O4/Bi2MoO6 heterojunction photocatalyst with enhanced visible light photocatalytic activity for malachite green removal. Appl. Surf. Sci. 492, 527–539 (2019).

    Google Scholar 

  26. Makhluf, S. et al. Microwave-assisted synthesis of nanocrystalline MgO and its use as a bacteriocide. Adv. Funct. Mater. 15 (10), 1708–1715 (2005).

    Google Scholar 

  27. Krishnamoorthy, K. et al. Antibacterial activity of MgO nanoparticles based on lipid peroxidation by oxygen vacancy. J. Nanopart. Res. 14, 1–10 (2012).

    Google Scholar 

  28. Kanagesan, S. et al. Cytotoxic effect of nanocrystalline MgFe2O4 particles for cancer cure. J. Nanomaterials. 2013 (1), 865024 (2013).

    Google Scholar 

  29. Horev-Azaria, L. et al. Predictive toxicology of cobalt ferrite nanoparticles: comparative in-vitro study of different cellular models using methods of knowledge discovery from data. Part. Fibre Toxicol. 10, 1–17 (2013).

    Google Scholar 

  30. Ahmad, J. et al. Differential cytotoxicity of copper ferrite nanoparticles in different human cells. J. Appl. Toxicol. 36 (10), 1284–1293 (2016).

    Google Scholar 

  31. Mahesh, B. A comprehensive review on current trends in greener and sustainable synthesis of ferrite nanoparticles and their promising applications. Results Eng. 21, 101702 (2024).

    Google Scholar 

  32. Abdo, M., Al-Wafi, R. & AlHammad, M. Highly efficient visible light driven photocatalytic activity of rare earth cerium doped zinc-manganese ferrite: Rhodamine B degradation and stability assessment. Ceram. Int. 49 (17), 29245–29258 (2023).

    Google Scholar 

  33. Cory, A. H. et al. Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture. Cancer Commun. 3 (7), 207–212 (1991).

    Google Scholar 

  34. Tantawy, M. A. et al. Molecular docking study, cytotoxicity, cell cycle arrest and apoptotic induction of novel chalcones incorporating thiadiazolyl isoquinoline in cervical cancer. Anti-Cancer Agents Med. Chem. (Formerly Curr. Med. Chemistry-Anti-Cancer Agents). 20 (1), 70–83 (2020).

    Google Scholar 

  35. Vallabani, N. S. et al. ZnO nanoparticles-associated mitochondrial stress-induced apoptosis and G2/M arrest in HaCaT cells: a mechanistic approach. Mutagenesis 34 (3), 265–277 (2019).

    Google Scholar 

  36. Bonetta, L. Prime time for real-time PCR. Nat. Methods. 2 (4), 305–312 (2005).

    Google Scholar 

  37. Sengupta, A. & Sarkar, C. K. Introduction to nano: basics to nanoscience and nanotechnology (Springer, 2015).

  38. Kelsall, R. Nanoscale Science and Technology (John Wiley and Sons, Ltd., 2005).

  39. Al-Bassami, N. et al. Ce-Co-Mn-Zn ferrite nano catalyst: A synergetic effect of rare earth Ce3 + on enhanced optical properties and photocatalysis. Ceram. Int. 49 (12), 20601–20612 (2023).

    Google Scholar 

  40. Dasent, W. E. Inorganic energetics: an introduction (CUP Archive, 1982).

  41. Mansour, S., Abdo, M. & El-Dek, S. Improvement of physico-mechanical properties of Mg–Zn nanoferrites via Cr3 + doping. J. Magn. Magn. Mater. 422, 105–111 (2017).

    Google Scholar 

  42. Zayed, M. A. et al. Impacts of lanthanum on tuning structural, magnetic, optical, and photocatalytic features of zinc-manganese nanoferrites (Ceramics International, 2025).

  43. Shannon, R. D. Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides. Found. Crystallogr. 32 (5), 751–767 (1976).

    Google Scholar 

  44. Ranga, R., Kumar, K. & Kumar, A. Morphology, structural, dielectric and magnetic study of Ce3 + ion doped Mg0. 5Zn0. 5Fe2-xCexO4 (0.0 ≤ x ≤ 0.1) ferrite nanoparticles. Materials Chemistry and Physics, 289: p. 126482. (2022).

  45. Potangale, C. N. & Pardeshi, S. K. Effect of Ni2 + substitution on magnetic, optical and electrical properties of SrFe2O4. Mater. Sci. Engineering: B. 283, 115848 (2022).

    Google Scholar 

  46. Debnath, S. & Das, R. Cobalt doping on nickel ferrite nanocrystals enhances the micro-structural and magnetic properties: shows a correlation between them. J. Alloys Compd. 852, 156884 (2021).

    Google Scholar 

  47. Sadeq, M. et al. Compositional dependency of morphology, elastic parameters and radiation shielding features in Co–Zn–Cr-nanoferrite materials. Radiat. Phys. Chem. 231, 112583 (2025).

    Google Scholar 

  48. Jan, R. Understanding apoptosis and apoptotic pathways targeted cancer therapeutics. Adv. Pharm. Bull. 9 (2), 205 (2019).

    Google Scholar 

  49. Maria, M. F. et al. Evaluating Nanoparticle-Induced Cytotoxicity: Mechanisms and Methods. Nano Biomed. Eng. 17 (4), 481–504 (2025).

    Google Scholar 

  50. Mansour, S., Abdo, M. & Kzar, F. Effect of Cr dopant on the structural, magnetic and dielectric properties of Cu-Zn nanoferrites. J. Magn. Magn. Mater. 465, 176–185 (2018).

    Google Scholar 

  51. Diao, Y. et al. Dual-responsive magnetic nanozyme Cu-CuFe₂O₄ leverages mild magnetic hyperthermia and redox dyshomeostasis to potentiate cuproptosis. Colloids Surf., B, : p. 115146. (2025).

  52. Jasrotia, R. et al. Advances in magnesium spinel ferrites for photocatalytic degradation of methylene blue: Challenges and future prospectives (Journal of Magnesium and Alloys, 2025).

  53. Schmid, G. Nanoparticles: from theory to application (Wiley, 2011).

  54. Hongmei, Z. Extrinsic and intrinsic apoptosis signal pathway review, in Apoptosis and medicine. InTechOpen. (2012).

  55. Chen, N. et al. Multifunctional CuFe2O4@ HA as a GSH-depleting nanoplatform for targeted photothermal/enhanced-chemodynamic synergistic therapy. Colloids Surf., B. 229, 113445 (2023).

    Google Scholar 

  56. Motoyama, N. & Naka, K. DNA damage tumor suppressor genes and genomic instability. Curr. Opin. Genet. Dev. 14 (1), 11–16 (2004).

    Google Scholar 

  57. Tong, W. M. et al. DNA strand break-sensing molecule poly (ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression (Molecular and Cellular Biology, 2001).

  58. Wei, C. et al. Fucoidan inhibits proliferation of the SKM-1 acute myeloid leukaemia cell line via the activation of apoptotic pathways and production of reactive oxygen species. Mol. Med. Rep. 12 (5), 6649–6655 (2015).

    Google Scholar 

  59. Aggarwal, P. et al. Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication. Genes Dev. 21 (22), 2908–2922 (2007).

    Google Scholar 

  60. Li, Z. et al. Alternative cyclin D1 splice forms differentially regulate the DNA damage response. Cancer Res. 70 (21), 8802–8811 (2010).

    Google Scholar 

  61. Shimura, T. et al. Cyclin D1 overexpression perturbs DNA replication and induces replication-associated DNA double-strand breaks in acquired radioresistant cells. Cell. cycle. 12 (5), 773–782 (2013).

    Google Scholar 

  62. Wan, R. et al. DNA damage caused by metal nanoparticles: involvement of oxidative stress and activation of ATM. Chem. Res. Toxicol. 25 (7), 1402–1411 (2012).

    Google Scholar 

  63. Golbamaki, N. et al. Genotoxicity of metal oxide nanomaterials: review of recent data and discussion of possible mechanisms. Nanoscale 7 (6), 2154–2198 (2015).

    Google Scholar 

  64. Shukla, R. K. et al. Genotoxic potential of nanoparticles: structural and functional modifications in DNA. Front. Genet. 12, 728250 (2021).

    Google Scholar 

Download references

Related Posts