Targeting of specific neuronal types in the non-human primate brain by using a murine CD25-specific recombinant immunotoxin

targeting-of-specific-neuronal-types-in-the-non-human-primate-brain-by-using-a-murine-cd25-specific-recombinant-immunotoxin
Targeting of specific neuronal types in the non-human primate brain by using a murine CD25-specific recombinant immunotoxin

References

  1. Rogers, J. & Gibbs, R. A. Comparative primate genomics: Emerging patterns of genome content and dynamics. Nat. Rev. Genet. 15, 347–359 (2014).

    Google Scholar 

  2. Shao, Y. et al. Phylogenomic analyses provide insights into primate evolution. Science 380, 913–924 (2023).

    Google Scholar 

  3. Petrides, M. Lateral prefrontal cortex: architectonic and functional organization. Philos. Trans. R Soc. Lond. B Biol. Sci. 360, 781–795 (2005).

    Google Scholar 

  4. Sallet, J. et al. The organization of dorsal frontal cortex in humans and macaques. J. Neurosci. 33, 12255–12274 (2013).

    Google Scholar 

  5. Hori, Y. et al. Interspecies activation correlations reveal functional correspondences between marmoset and human brain areas. Proc. Natl. Acad. Sci. U.S.A. 118, e2110980118 (2021).

  6. Burns, R. S. et al. A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by n-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc. Natl. Acad. Sci. U.S.A. 80, 4546–4550 (1983).

  7. Chiueh, C. C., Burns, R. S., Markey, S. P., Jacobowitz, D. M., Kopin, I. J. & D.M. & Primate model of parkinsonism: selective lesion of nigrostriatal neurons by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine produces an extrapyramidal syndrome in rhesus monkeys. Life Sci. 36, 213–218 (1985).

    Google Scholar 

  8. DeLong, M. R. Primate models of movement disorders of basal ganglia origin. Trends Neurosci. 13, 281–285 (1990).

    Google Scholar 

  9. Peter Jenner, P. et al. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in the common marmoset. Neurosci. Lett. 50, 85–90 (1984).

    Google Scholar 

  10. Beaudry, F. & Huot, P. The MPTP-lesioned marmoset model of parkinson’s disease: proposed efficacy thresholds that May potentially predict successful clinical trial results. J. Neural Transm (Vienna). 127, 1343–1358 (2020).

    Google Scholar 

  11. Shi, L. et al. Clioquinol improves motor and non-motor deficits in MPTP-induced monkey model of Parkinson’s disease through AKT/mTOR pathway. Aging (Albany NY). 12, 9515–9533 (2020).

    Google Scholar 

  12. Kang, W. et al. The mGluR2/3 orthosteric agonist LY-404 039 reduces dyskinesia psychosis-like behaviours parkinsonism MPTP-lesioned marmoset. Naunyn Schmiedebergs Arch. Pharmacol. 396, 2347–2355 (2023).

    Google Scholar 

  13. Kwan, C. et al. Selective Blockade of the 5-HT receptor acutely alleviates dyskinesia psychos parkinsonian marmoset. Neuropharmacol. 182, 108386 (2021).

    Google Scholar 

  14. Boraud, T., Bezard, E., Bioulac, B. & Gross, C. High frequency stimulation of the internal globus pallidus (GPi) simultaneously improves parkinsonian symptoms and reduces the firing frequency of GPi neurons in the MPTP-treated monkey. Neurosci. Lett. 215, 17–20 (1996).

    Google Scholar 

  15. Dorval, A. D. et al. Deep brain stimulation reduces neuronal entropy in the MPTP-primate model of parkinson’s disease. J. Neurophysiol. 100, 2807–2818 (2008).

    Google Scholar 

  16. Kammermeier, S., Pittard, D., Hamada, I. & Wichmann, T. Effects of high-frequency stimulation of the internal pallidal segment on neuronal activity in the thalamus in parkinsonian monkeys. J. Neurophysiol. 116, 2869–2881 (2016).

    Google Scholar 

  17. Watanabe, S. et al. Functional and molecular characterization of a non-human primate model of autism spectrum disorder shows similarity with the human disease. Nat. Commun. 12, 5388 (2021).

    Google Scholar 

  18. Noguchi, J. et al. Altered projection-specific synaptic remodeling and its modification by oxytocin in an idiopathic autism marmoset model. Commun. Biol. 7, 642 (2024).

    Google Scholar 

  19. Chao, Z. C. et al. Erroneous predictive coding across brain hierarchies in a non-human primate model of autism spectrum disorder. Commun. Biol. 7, 851 (2024).

    Google Scholar 

  20. Nakamura, M. et al. Prenatal valproic acid-induced autism marmoset model exhibits higher salivary cortisol levels. Front. Behav. Neurosci. 16, 943759 (2022).

    Google Scholar 

  21. Kinoshita, M. et al. Genetic dissection of the circuit for hand dexterity in primates. Nature 487, 235–238 (2012).

    Google Scholar 

  22. Tohyama, T. et al. Contribution of propriospinal neurons to recovery of hand dexterity after corticospinal tract lesions in monkeys. Proc. Natl. Acad. Sci. U S A. 114, 604–609 (2017).

    Google Scholar 

  23. Inoue, K., Takada, M. & Matsumoto, M. Neuronal and behavioural modulations by pathway-selective optogenetic stimulation of the primate oculomotor system. Nat. Commun. 6, 8378 (2015).

    Google Scholar 

  24. Afraz, A., Boyden, E. S. & DiCarlo, J. J. Optogenetic and pharmacological suppression of spatial clusters of face neurons reveal their causal role in face gender discrimination. Proc. Natl. Acad. Sci. U.S.A. 12, 6730–6735 (2015).

    Google Scholar 

  25. Galvan, A. et al. Nonhuman primate optogenetics: recent advances and future directions. J. Neurosci. 37, 10894–10903 (2017).

    Google Scholar 

  26. Mimura, K. et al. Chemogenetic activation of nigrostriatal dopamine neurons in freely moving common marmosets. iScience 24, 103066 (2021).

    Google Scholar 

  27. Chen, Y. et al. Circuit-specific gene therapy reverses core symptoms in a primate parkinson’s disease model. Cell 186, 5394–5410e18 (2023).

    Google Scholar 

  28. Raper, J. & Galvan, A. Applications of chemogenetics in non-human primates. Curr. Opin. Pharmacol. 64, 102204 (2022).

    Google Scholar 

  29. Kobayashi, K. et al. Immunotoxin-mediated conditional disruption of specific neurons in transgenic mice. Proc. Natl. Acad. Sci. U S A. 92, 1132–1136 (1995).

    Google Scholar 

  30. Kobayashi, K. Controlled cell targeting system to study the brain neural circuitry. Neurosci. Res. 58, 118–123 (2007).

    Google Scholar 

  31. Kobayashi, K., Okada, K. & Kai, N. Controlled genetic manipulations, Functional circuitry analysis in rodents using neurotoxins/immunotoxins. In Neuromethods, vol. 65 (ed. Alexei, M.) 193–205 (Humana Press, New York, 2012).

    Google Scholar 

  32. Chaudhary, V. K. et al. A Recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin. Nature 339, 394–397 (1989).

    Google Scholar 

  33. Kreitman, R. J., Bailon, P., Chaudhary, V. K., FitzGerald, D. J. & Pastan, I. Recombinant immunotoxins containing anti-Tac(Fv) and derivatives of Pseudomonas exotoxin produce complete regression in mice of an interleukin-2 receptor-expressing human carcinoma. Blood 83, 426–434 (1994).

    Google Scholar 

  34. Watanabe, D. et al. Ablation of cerebellar golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination. Cell 95, 17–27 (1998).

    Google Scholar 

  35. Sawada, H. et al. Autonomic neuropathy in transgenic mice caused by immunotoxin targeting of the peripheral nervous system. J. Neurosci. Res. 51, 162–173 (1998).

    Google Scholar 

  36. Yoshida, K. et al. A key role of starburst Amacrine cells in originating retinal directional selectivity and optokinetic eye movement. Neuron 30, 771–780 (2001).

    Google Scholar 

  37. Nishizawa, K. et al. Striatal indirect pathway contributes to selection accuracy of learned motor actions. J. Neurosci. 32, 13421–13432 (2012).

    Google Scholar 

  38. Fukabori, R. et al. Striatal direct pathway modulates response time in execution of visual discrimination. Eur. J. Neurosci. 35, 784–797 (2012).

    Google Scholar 

  39. Okada, K. et al. Enhanced flexibility of place discrimination learning by targeting striatal cholinergic interneurons. Nat. Commun. 5, 3778 (2014).

    Google Scholar 

  40. Ozawa, T. et al. A novel rabbit immunospot array assay on a chip allows for the rapid generation of rabbit monoclonal antibodies with high affinity. PLoS One 7, e52383 (2012).

    Google Scholar 

  41. Ozawa, T. et al. Rapid and efficient generation of T-cell receptor-like antibodies using chip-based single-cell analysis. Eur. J. Immunol. 51, 1850–1853 (2021).

    Google Scholar 

  42. Kato, S. et al. Selective neural pathway targeting reveals key roles of thalamostriatal projection in the control of visual discrimination. J. Neurosci. 31, 17169–17179 (2011).

    Google Scholar 

  43. Kato, S., Kobayashi, K. & Kobayashi, K. Dissecting circuit mechanisms by genetic manipulation of specific neural pathways. Rev. Neurosci. 24, 1–8 (2013).

    Google Scholar 

  44. Kato, S. et al. Action selection and flexible switching controlled by the intralaminar thalamic neurons. Cell. Rep. 22, 2370–2382 (2018).

    Google Scholar 

  45. Kato, S. et al. Neuron-specific gene transfer through retrograde transport of lentiviral vector pseudotyped with a novel type of fusion envelope glycoprotein. Hum. Gene Ther. 22, 1511–1523 (2011).

    Google Scholar 

  46. Kato, S. et al. Improved transduction efficiency of a lentiviral vector for neuron- specific retrograde gene transfer by optimizing the junction of a fusion envelope glycoprotein. J. Neurosci. Methods 227, 151–158 (2014).

    Google Scholar 

  47. Kobayashi, K., Kato, S., Inoue, K., Takada, M. & Kobayashi, K. Altering entry site preference of lentiviral vectors into neuronal cells by pseudotyping with envelope glycoproteins. Methods Mol. Biol. 1382, 175–186 (2016).

    Google Scholar 

  48. Nikaido, T. et al. Molecular cloning of cDNA encoding human interleukin-2 receptor. Nature 311, 631–635 (1984).

    Google Scholar 

  49. Shimizu, A. et al. Nucleotide sequence of mouse IL-2 receptor cDNA and its comparison with the human IL-2 receptor sequence. Nucleic Acids Res. 13, 1505–1516 (1985).

    Google Scholar 

  50. Silvertown, J. D., Walia, J. S. & Medin, J. A. Cloning, sequencing and characterization of lentiviral-mediated expression of rhesus macaque (Macaca mulatta) interleukin-2 receptor alpha cDNA. Dev. Comp. Immunol. 29, 989–1002 (2005).

    Google Scholar 

  51. Kofu, K. et al. Comparison of 30 immunity-related genes from the common marmoset with orthologues from human and mouse. Tohoku J. Exp. Med. 215, 167–180 (2008).

    Google Scholar 

  52. Inoue, K. et al. Immunotoxin-mediated tract targeting in the primate brain: selective elimination of the cortico-subthalamic hyperdirect pathway. PLoS One 7, e39149 (2012).

    Google Scholar 

  53. Takada, M. et al. Elucidating information processing in primate basal ganglia circuitry: A novel technique for pathway-selective ablation mediated by immunotoxin. Front. Neural Circuits. 7, 140 (2013).

    Google Scholar 

  54. Araujo, D. M., Lapchak, P. A., Collier, B. & Quirion, R. Localization of interleukin-2 immunoreactivity and interleukin-2 receptors in the rat brain: interaction with the cholinergic system. Brain Res. 498, 257–266 (1989).

    Google Scholar 

  55. Wang, G. et al. Immunohistochemical localization of interleukin-2 and its receptor subunits alpha, beta and gamma in the main olfactory bulb of the rat. Brain Res. 893, 244–252 (2001).

    Google Scholar 

  56. Hofman, F. M. et al. Immunoregulatory molecules and IL 2 receptors identified in multiple sclerosis brain. J. Immunol. 136, 3239–3245 (1986).

    Google Scholar 

  57. Goldeck, D. et al. Enhanced chemokine receptor expression on leukocytes of patients with alzheimer’s disease. PLoS One. 8, e66664 (2013).

    Google Scholar 

  58. Zhang, Y., Kong, Q., Fan, J. & Zhao, H. Interleukin-2 and its receptors: implications and therapeutic prospects in immune-mediated disorders of central nervous system. Pharmacol. Res. 213, 107658 (2025).

    Google Scholar 

  59. Onda, M. Recombinant immunotoxins with low endotoxins for clinical and animal studies. Methods Mol. Biol. 907, 627–643 (2012).

    Google Scholar 

  60. Seki, F. et al. Multidimensional MRI-CT atlas of the naked mole-rat brain (Heterocephalus glaber). Front. Neuroanat. 7, 45 (2013).

    Google Scholar 

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